LOX Antibody

Product Specs
ItemLOX Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $459.00Supplier Page View Company Product Page
Catalog NumberNB100-2527
ImmunogenA synthetic peptide made to an internal region of the human LOX protein (within residues 200-300). [Swiss-Prot P28300]
Concentration1.0 mg/ml
Quantity0.1 ml (also 0.025 ml)
FormatPBS
Conjugate/TagUnconjugated
TargetLOX
HostRabbit
ApplicationsIF/IHC,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Knockdown Validated,Immunocytochemistry/ Immunofluorescence
ReactivityFeline,Human,Mouse,Porcine,Rat
NCBI Full Gene Namelysyl oxidase
ClonalityPolyclonal
PurityImmunogen affinity purified
Research AreaCancer, Cell Biology, Cellular Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Signal Transduction
NCBI Gene AliasesAAT10
IsotypeIgG
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Sizes Available: 0.1 ml (also 0.025 ml)

Questions and Answers

Can this antibody be used to study lysyl oxidase expression in feline models, particularly in relation to hypertrophic cardiomyopathy?

Yes, the LOX antibody has been shown to detect increased lysyl oxidase expression in both cardiomyocytes and interstitial mononuclear cells in feline hypertrophic cardiomyopathy, as demonstrated in a study that explored myocardial remodeling in affected cats ().

Is the LOX antibody effective for immunohistochemistry applications in human tissues?

The LOX antibody has been utilized successfully in immunohistochemistry to assess lysyl oxidase expression in various studies, including those investigating liver fibrosis and esophageal conditions, indicating its effectiveness in human tissue applications (, ).

How does the LOX antibody perform in Western blotting experiments?

The LOX antibody has been employed in Western blotting to analyze lysyl oxidase levels in multiple studies, including those examining tumor progression and fibrosis, confirming its utility in detecting LOX protein expression in various experimental contexts (, ).

What role does lysyl oxidase play in cancer progression, and how is this relevant to the use of the LOX antibody?

Lysyl oxidase is implicated in extracellular matrix remodeling and has been associated with both tumor-promoting and tumor-suppressing roles in cancer. The LOX antibody can be used to investigate these dual roles in various cancer models, as seen in studies focusing on prostate cancer and hepatocellular carcinoma (, ).

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular DysfunctionJournal of the American Heart AssociationJuly 16, 2024Brianna F. Moon, Iris Y. Zhou, Yingying Ning, Yin‐Ching I. Chen, Mariane Le Fur, Sergey Shuvaev, Eman A. Akam, Hua Ma, Cesar Molinos Solsona, Jonah Weigand‐Whittier, et al.and heart tissues were detected using immunohistochemistry assays with antibodies against LOX (1:250; NB100‐2527, Novus Biologicals) and transglutaminase (1:250; ab421, Abcam; protocol provided in Data S1). The slides

(2) Simultaneous Positron Emission Tomography and Molecular Magnetic Resonance Imaging of Cardiopulmonary Fibrosis in a Mouse Model of Left Ventricular DysfunctionJ Am Heart AssocJuly 9, 2024Brianna F. Moon, Iris Y. Zhou, Yingying Ning, Yin‐Ching I. Chen, Mariane Le Fur, Sergey Shuvaev, Eman A. Akam, Hua Ma, Cesar Molinos Solsona, Jonah Weigand‐Whittier, et al.and heart tissues were detected using immunohistochemistry assays with antibodies against LOX (1:250; NB100‐2527, Novus Biologicals) and transglutaminase (1:250; ab421, Abcam; protocol provided in Data S1). The slides

(3) Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilizationNature communicationsMarch 9, 2023Wang Q, Sundar IK, Lucas JH, Park JG, Nogales A, Martinez-Sobrido L, Rahman I.Novus Biologicals), anti-COL1A1 (1:1000, NBP1-30054, Novus Biologicals), anti-activated LOX (1:1000, NB100-2527, Novus Biologicals) for Fig. 7 only, and anti-LOX (1:1000, ab174316, abcam). Then, the primary antibody

(4) Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-αThe Journal of allergy and clinical immunologyJanuary 1, 0001"Kasagi Y, Dods K, Wang JX, Chandramouleeswaran PM, Benitez AJ, Gambanga F, Kluger J, Ashorobi T, Gross J, Tobias JW, et al."sections were incubated with rabbit anti-LOX (1:100; Novus Biological, rabbit polycloncal antibody NB100–2527) 3435,36vernight at 4°C. Stained objects were captured and imaged with a Nikon Microphot microscope

(5) A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancerCell chemical biologyJanuary 1, 0001"Cetin M, Saatci O, Rezaeian AH, Rao CN, Beneker C, Sreenivas K, Taylor H, Pederson B, Chatzistamou I, Buckley B, et al."RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies LOX,Abcam,Cat#ab174316 LOX,Novus,Cat#NB100–2527 LOX,Sigma,Cat#L4794 LOXL1,Thermo Scientific,Cat#MA5–43676 LOXL2,Novus,Cat#NBP1–32954 Actin,Sigma,Cat#A2228 Collagen

(6) Intrauterine growth restriction influences vascular remodeling and stiffening in the weanling rat more than sex or dietAmerican journal of physiology. Heart and circulatory physiologyJanuary 1, 0001"Dodson RB, Miller TA, Powers K, Yang Y, Yu B, Albertine KH, Zinkhan EK."inhibitor of metalloproteinases 2 (TIMP-2; sc21735; 1:1,000; Santa Cruz Biotechnology), lysyl oxidase (LOX; NB100 –2527; 1:1,000; Novus Biologicals, Littleton, CO), advanced glycosylation end product specific receptor (AGER;

(7) Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study"Rheumatology (Oxford, England)"January 1, 0001"Vadasz Z, Balbir Gurman A, Meroni P, Farge D, Levi Y, Ingegnoli F, Braun-Moscovici Y, Rosner I, Slobodin G, Rozenbaum M, et al."

(8) Significance of Intratumoral Fibrosis in Clear Cell Renal Cell CarcinomaJournal of pathology and translational medicineJanuary 1, 0001"Joung JW, Oh HK, Lee SJ, Kim YA, Jung HJ."

(9) "Fibronectin promotes elastin deposition, elasticity and mechanical strength in cellularised collagen-based scaffolds"BiomaterialsJanuary 1, 0001"Pezzoli D, Di Paolo J, Kumra H, Fois G, Candiani G, Reinhardt DP, Mantovani D."

(10) Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heartCardiovascular researchJanuary 1, 0001"Herum KM, Lunde IG, Skrbic B, Louch WE, Hasic A, Boye S, Unger A, Brorson SH, Sjaastad I, Tønnessen T, et al."

(11) Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signalingBMC cancerJanuary 1, 0001"Nilsson G, Kannius-Janson M."performed at SCIBLU Microarray Resource Centre (MARC; Lund, Sweden). Antibodies LOX (Novus Biologicals, NB100-2527), FoxF1 (Human Protein Atlas project, HPA003454 (mAb FoxF1 3454)), FAK-pY576 and FAK (Invitrogen), FAK-pY396

(12) Inhibition of histone deacetylase causes emphysemaAmerican journal of physiology. Lung cellular and molecular physiologyJanuary 1, 0001"Mizuno S, Yasuo M, Bogaard HJ, Kraskauskas D, Natarajan R, Voelkel NF."

(13) Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patientsThe American journal of pathologyJanuary 1, 0001"Schlötzer-Schrehardt U, Pasutto F, Sommer P, Hornstra I, Kruse FE, Naumann GO, Reis A, Zenkel M."

(14) EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2NatureJanuary 1, 0001"Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, et al."

(15) Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndromeAmerican journal of physiology. Heart and circulatory physiologyJanuary 1, 0001"Zibadi S, Vazquez R, Moore D, Larson DF, Watson RR."

(16) "The copper chelator tetrathiomolybdate regressed bleomycin-induced pulmonary fibrosis in mice, by reducing lysyl oxidase expressions"Biological trace element researchJanuary 1, 0001"Ovet H, Oztay F."

(17) Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatmentScience translational medicineJanuary 1, 0001"Ning Y, Zhou IY, Roberts JD Jr, Rotile NJ, Akam E, Barrett SC, Sojoodi M, Barr MN, Punshon T, Pantazopoulos P, et al."expression in the liver tissue was detected using immunohistochemistry assays with antibody against LOX (NB100-2527, 1:100, Novus Biologicals). After deparaffinization and hydration of the paraffin-embedded liver sections,

(18) "Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics""Neoplasia (New York, N.Y.)"January 1, 0001"Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD."

(19) The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cellsExperimental cell researchJanuary 1, 0001"Teppo S, Sundquist E, Vered M, Holappa H, Parkkisenniemi J, Rinaldi T, Lehenkari P, Grenman R, Dayan D, Risteli J, et al."

(20) In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold"Biomedical materials (Bristol, England)"January 1, 0001"Hinderer S, Shena N, Ringuette LJ, Hansmann J, Reinhardt DP, Brucker SY, Davis EC, Schenke-Layland K."

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LOX Antibody

LOX Antibody

LOX Antibody

LOX Antibody

LOX Antibody - BSA Free from Novus Biologicals, a Bio-Techne Brand

Specifications/Features

Questions and Answers

Novus Biologicals, a Bio-Techne Brand

Citations (41)

Reviews

LOX Antibody - BSA Free from Novus Biologicals, a Bio-Techne Brand

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