Jak3 (D1H3) Rabbit mAb 8827S from Cell Signaling Technology

Product Specs
ItemJak3 (D1H3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8827S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetJak3
HostRabbit
NCBI Gene AliasesJAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
ClonalityMonoclonal
NCBI Full Gene NameJanus kinase 3
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD1H3
Molecular Weight115

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Dimethyl itaconate suppresses dendritic cell and CD8+ T cell responses to halt vitiligoBMC MedDecember 29, 2025Yinghan Wang, Yuhan Chen, Jingjing Ma, Linxuan Wu, Pan Kang, Jianru Chen, Pengran Du, Wei Wu, Xinju Wang, Kaiqiao He, et al.Cat#3230), anti-p-JAK3 (Cell Signaling Technology, Cat#5031), anti-JAK3 (Cell Signaling Technology, Cat# 8827), anti-p-STAT1 (Cell Signaling Technology, Cat#7649), anti-STAT1 (Cell Signaling Technology, Cat#14,994),

(2) XPO1 inhibitor selinexor enhances the apoptotic effect of azacitidine in T-cell lymphoma with TET2/RHOA mutations via JAK3/STAT3 axisCell Commun SignalDecember 23, 2025Ting-Ting Xu, Ming-Ci Cai, Shu Cheng, Yao-Hui Huang, Qian-Qian Zhang, Peng-Peng Xu, Li Wang, Yu-Ran Qiu, Wei-Li Zhao(10993–1-AP, Proteintech), PARP (66520–1-Ig, Proteintech), p-JAK3 (Tyr980/981) (#5031, CST), JAK3 (#8827, CST), p-STAT3 (Tyr705) (AF00753, AiFang Biological), STAT3 (#12640, CST), SOCS1 (AF03521, AiFang Biological),

(3) A soft-stiff patterned bioengineering model reveals kinase pathways driving directional cell migration in pulmonary arterial hypertensionBiomaterials ScienceOctober 7, 2025Tamanna Islam, Jacob Hooper, Xiaojun Zhang, Clarissa Garcia, Md Mahedi Hasan, David H. Drewry, Mohammad Anwar Hossain, Taslim A. Al-Hilaldilution of 1 : 1500, which was prepared in a 5% BSA solution. The antibodies used are anti-JAK3 (#8827s, Cell Signaling Technology Inc.), anti-phospho JAK3 (#5031, Cell Signaling Technology Inc.), anti-STAT3

(4) Overcoming platinum-resistant ovarian cancer targeting the activated JAK-STAT pathways via extracellular vesiclesCommun BiolAugust 29, 2025Kazuhiro Suzuki, Akira Yokoi, Kosuke Yoshida, Hironori Suzuki, Masami Kitagawa, Eri Asano-Inami, Seiko Matsuo, Masato Yoshihara, Satoshi Tamauchi, Nobuhisa Yoshikawa, et al.1:1000), phospho-Jak2 rabbit antibody (#3776, Cell Signaling Technology, 1:1000), JAK3 rabbit antibody (#8827, Cell Signaling Technology, 1:1000), phospho-JAK3 rabbit antibody (#5031, Cell Signaling Technology,

(5) Faecalibacterium prausnitzii promotes anti-PD-L1 efficacy in natural killer/T-cell lymphoma by enhancing antitumor immunityBMC medicineJuly 1, 2025Shi Z, Jiang W, Li H, Zhang Y, Xue W, Wang Y, Zhang M, Li Z.(1:1,000, Proteintech, #60004–1-Ig) as an internal reference, and anti-Jak3 (D1H3) mAb (1:1,000, CST, #8827), anti-phospho-JAK3 (Tyr980/981) pAb (1:1,000, Proteintech, #29101–1-AP), anti-STAT3 mAb (1:1,000, Proteintech,

(6) The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressorBiochemical JournalApril 11, 2025Zhong-Yin Zhang, Yunpeng Bai, Sarah M. Cavender, Sarah M Cavender, Frederick Nguele Meke, Frederick Lasse-Opsahl, Emily L Lasse-Opsahl, Gina M. Doody, W. Andy Doody, Zhong-Yin Zhang(#9139, 1:1000), pSTAT3 (Tyr705, #9145, 1:1000), Ubiquitin (#3936, 1:1000), JAK1 (#3344, 1:1000), JAK3 (#8827, 1:1000) from Cell Signaling; pPTEN (Tyr336, F48744, 1:500) from NSJ Bioreagents; pJAK2 (Tyr570, PA5-104705,

(7) JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathwayJ Immunother CancerApril 8, 2025Ning Lou, Mengwei Yang, Zucheng Xie, Ruyun Gao, Lei Zhang, Le Tang, Jiarui Yao, Xiaohong Han, Yuankai ShiTBST for 1 hour. The membranes were then incubated with primary antibodies specific for JAK3 (1:1000, 8827S, Cell Signaling Technology), p-JAK3 (1:1000, 5031S, Cell Signaling Technology), STAT3 (1:1000, 4904T,

(8) Microglial Lcn2 knockout enhances chronic intracerebral hemorrhage recovery by restoring myelin and reducing inflammationTheranosticsMarch 29, 2025Li Wang, Lei Zhang, Kai Wang, Jun He, Liang Yuan, Yangang Wang, Weihao Lv, Zehan Zhang, Yuan Feng, Hongchen Zhang, et al.(BioLegend, 141708), Anti-Gdf-1 (Biorbyt, orb522485), Anti-P-Jak3Tyr980/981 (CST, 5031), Anti-Jak3 (CST, 8827), Anti-P-Stat3 Tyr705 (CST, 9145), Anti-Stat3 (CST, 9139) and Anti-H3 (CST, 9715). Luxol Fast Blue

(9) PLZF-expressing CD4+ T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signalingCell Commun SignalMarch 15, 2025Meng Zhang, Sheng-Ce Tao, Na Li, Jingjing Feng, Tianyun Shi, Yunxia Yu, Xiaoting Ren, Jiafeng Sha, Zhoufang Mei, Zhijun JieABclonal), JAK1 rabbit mAb (NO.3344, 1:1000, Cell signaling Technology, Danvers, USA) and JAK3 mAb (NO.8827, 1:1000, Cell signaling Technology). After washing with TBST, the membranes were incubated with an anti-rabbit

(10) The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoproteinNature CommunicationsJune 25, 2024Suchitra Mohanty, Sujit Suklabaidya, Alfonso Lavorgna, Takaharu Ueno, Jun-ichi Fujisawa, Nyater Ngouth, Steven Jacobson, Edward W. Harhaj(#9246), pIKKα/β (#2697), IKKβ (#8943), IκBα (#4812), KDR (#2479), JAK1 (#3344), JAK2 (#3230), JAK3 (#8827), pJAK1 (#74129), pJAK2 (#8082), pJAK3 (#5031), STAT1 (#14994), STAT3 (#4904), pSTAT1 (#7649), pSTAT3

(11) JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma developmentJournal of Cell Communication and SignalingFebruary 7, 2024Qingqing Hu, Ning Dou, Qiong Wu, Yong Gao, Yandong Li, Jingde Chen#3011), STAT5 (1:1000, Cell Signaling Technology, #25656), JAK3 (1:1000, Cell Signaling Technology, #8827), Phospho‐Akt (Ser473) (1:1000, Cell Signaling Technology, #9271), Akt Antibody (1:1000, Cell Signaling Technology

(12) IL-6/JAK2-dependent G6PD phosphorylation promotes nucleotide synthesis and supports tumor growthMolecular MetabolismDecember 1, 2023Xuemei Qiu, Hongping Ye, Xiaofei Li, Dan Li, Lu Jiang, Rui Liu, Zhe Zhao, Dan HeMaterials Antibodies recognizing JAK2 (#3230), STAT3 pY705 (#9145), JAK2 pY1007 (#4406), JAK1 (#77692), JAK3 (#8827) STAT3 (#9139), and Tyk2 (#14193) were purchased from Cell Signaling Technology. Human recombinant IL-6

(13) Reprogramming of PD-1+ M2-like tumor-associated macrophages with anti–PD-L1 and lenalidomide in cutaneous T cell lymphomaJCI InsightJuly 10, 2023Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Daniel Schmolze, Chingyu Su, Jasmine Zain, Lilach Moyal, Emmilia Hodak, James F. Sanchez, et al.System (Bio-Rad). Proteins underwent IB with the following Abs: JAK3 (Cell Signaling Technology, catalog 8827S), STAT1 (Cell Signaling Technology, catalog 9172S), p-STAT3 (Cell Signaling Technology, catalog 9131S),

(14) CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune ResponseCell transplantationJanuary 1, 2023Cao L, Ma X, Zhang J, Yang M, He Z, Yang C, Li S, Rong P, Wang W.Abcam, UK), rabbit anti-JAK3 (1:1000, #8827T; CST, USA), and rabbit anti-phosphorylated-JAK3 (1:1000, #8827S; CST, USA). Mouse anti-beta-actin (1:5,000, #66009-1-Ig; Proteintech, Rosemount, IL, USA) was used as

(15) Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of miceActa biochimica et biophysica SinicaApril 25, 2022Tang H, Liang T, Zhou Y, Ju H, Song D, Fang H.the antibodies are shown as follows: antibodies against JAK1 (CST-3344), JAK2 (CST-3230), JAK3 (CST-8827), TYK2 (CST-14193), STAT1 (CST-14994), STAT2 (CST-72604), STAT3 (CST-30835), STAT4 (CST-2653), STAT5

(16) Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell reportsFebruary 22, 2022Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, Zuckerman B, Lindzen M, Tarcitano E, Srivastava S, et al.anti-SMAD2/3,Cell Signaling Technology,Cat# 5678 Rabbit monoclonal anti-pSMAD2/3,Cell Signaling Technology,Cat# 8827 Goat Polyclonal anti-TGFbeta- R2,R & D systems,Cat# AF241 Rabbit monoclonal IgG Isotype control,Abcam,Cat#

(17) Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cellsMolecular OncologyJanuary 1, 2022Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marshall Pitz, Sabine Hombach‐Klonisch, Thomas KlonischpSTAT3Ser727 (D8C2Z; #94994), total STAT3 (D1A5; #8768), pJAK3Tyr980/981 (D44E3; #5031), total JAK3 (D1H3; #8827), Cdc42 antibody #4651, ARP3 antibody #4738, WAVE‐2 (D2C8; #3659), profilin‐1 (C56B8; #3246), N‐WASP

(18) Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastomaCancer cellJune 14, 2021Hara T, Chanoch-Myers R, Mathewson ND, Myskiw C, Atta L, Bussema L, Eichhorn SW, Greenwald AC, Kinker GS, Rodman C, et al.Cell Signaling, #3230), anti-p-Jak2-Tyr1008 (1:1000, Cell Signaling, #8082), anti-Jak3 (1:1000, Cell Signaling, #8827), anti-p-Jak3-Tyr980/981 (1:1000, Cell Signaling, #5031), and anti-beta-tubulin mouse antibody (1:5000,

(19) The LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancerNPJ breast cancerMay 31, 2021Tu Z, Schmoellerl J, Mariani O, Zheng Y, Hu Y, Vincent-Salomon A, Karnoub AE.GAPDH (#2118), JAK1 (#3344), p-JAK1 (Y1034/1035) (#74129), JAK2 (#3230), p-JAK2 (Y1008) (#8082), JAK3 (#8827), p-JAK3 (Y980/981) (#5031), TYK2 (#14193), p-TYK2 (Y1054/1055) (#68790), STAT1 (#14994), p-STAT1 (Tyr

(20) Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in miceCommunications biologyMarch 25, 2021Barcia Durán JG, Lu T, Houghton S, Geng F, Schreiner R, Xiang J, Rafii S, Redmond D, Lis R.Corning, 21-031-CV), and immuno-blotted with antibodies obtained from Cell Signaling against JAK3 (8827s) or GAPDH (5174), respectively. Primary antibody incubations were carried out in 5% wt/vol reconstituted

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Jak3 (D1H3) Rabbit mAb

Jak3 (D1H3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Jak3 (D1H3) Rabbit mAb from Cell Signaling Technology

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