Phospho-DRP1 (Ser637) (D3A4) Rabbit mAb from Cell Signaling Technology

Yes, the Phospho-DRP1 (Ser637) (D3A4) Rabbit mAb has been utilized in studies investigating mitochondrial dynamics, particularly in glioblastoma multiforme cells. It has been shown that interfering with mitochondrial dynamics can sensitize these cancer cells to chemotherapy, highlighting the role of phosphorylated DRP1 in regulating mitochondrial morphology and function during treatment with temozolomide (wang2022).

The Phospho-DRP1 (Ser637) antibody has been referenced in studies examining the effects of high glucose on cardiomyocyte hypertrophy, where it was found that phosphorylation at Ser637 is involved in the regulation of mitochondrial fission and function under oxidative stress conditions (wu2021).

This antibody is reactive with rat samples and has been cited in multiple studies, including those focusing on mitochondrial function and dynamics in various contexts, such as Parkinson's disease and radiation therapy (deus2021, guo2022).

Phosphorylation of DRP1 at Ser637 is crucial for maintaining mitochondrial dynamics. Studies have shown that this modification can prevent mitochondrial damage and promote mitochondrial homeostasis, particularly in response to different stressors, such as radiation therapy (guo2022).