LAMTOR2/ROBLD3 (D7C10) Rabbit mAb 8145S from Cell Signaling Technology

Product Specs
ItemLAMTOR2/ROBLD3 (D7C10) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8145S
ClonalityMonoclonal
NCBI Full Gene Namelate endosomal/lysosomal adaptor, MAPK and MTOR activator 2
ApplicationsWB, IP
ReactivityHu, Ms, Rt, Mk
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneD7C10
Molecular Weight14
NCBI Gene AliasesENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14
HostRabbit
TargetLAMTOR2
Quantity100 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon productionThe EMBO JournalJanuary 22, 2026Zeming Feng, Lulu Wang, Shujun Chen, Sihan Cao, Miao Lei, Xiuzhen Yang, Kaixiong Ma, Shi Yu, Huina Hu, Kaixuan Zheng, et al.(IB 1:1000),Cell Signaling Technology,#8975 (D11H6) Lamtor2 (IB 1:1000),Cell Signaling Technology,#8145 (D7C10) Lamtor3 (IB 1:1000),Cell Signaling Technology,#8168 (D38G5) Lamtor4 (IB 1:1000),Cell Signaling Technology

(2) Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axisThe EMBO JournalJanuary 28, 2025Yan Huang, Hua Lu, Yao Liu, Jiabei Wang, Qingan Xia, Xiangmin Shi, Yan Jin, Xiaolin Liang, Wei Wang, Xiaopeng Ma, et al.(Abcam, UK, ab134953), SLC38A2 (ImmunoWay, USA, YT4354), LAMTOR1(CST, USA, 8975), LAMTOR2 (CST, USA, 8145), LAMTOR3 (Proteintech, USA, 14492-1-AP), LAMTOR4 (CST, USA, 13140), LAMTOR5 (Proteintech, USA,11937-1-AP),

(3) LAMTOR1 regulates dendritic lysosomal positioning in hippocampal neurons through TRPML1 inhibitionFrontiers in Cellular NeuroscienceNovember 22, 2024Jiandong Sun, Weiju Lin, Xiaoning Hao, Michel Baudry, Xiaoning Bianti-LAMTOR1,Sigma-Aldrich,Cat#HPA002997 Rabbit monoclonal anti-LAMTOR2,Cell Signaling Technology,Cat#8145 Rat monoclonal anti-LAMP2,Abcam,Cat#ab13524 Goat polyclonal anti-Cathepsin B,R&D Systems,Cat#AF965 Rabbit

(4) Proteomic Investigation of Differential Interactomes of Glypican 1 and a Putative Disease-Modifying Variant of AtaxiaJournal of Proteome ResearchSeptember 1, 2023Nur Cengiz Winter, Mert Karakaya, Peter Mosen, Isabell Brusius, Banu Anlar, Goknur Haliloglu, Dominic Winter, Brunhilde WirthProteintech: 67188-1-Ig), α-CANX (1:1000, Proteintech: 10427-2-AP), LAMTOR2 (1:1000, Cell Signaling: 8145), α-HSP90 (1:1000, Cell Signaling: C45G5), ATP6V1F (1:1000, Proteintech: 17725-1-AP), α-EGFR (1:1000,

(5) Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformationNature communicationsJuly 3, 2023Calcagni' A, Staiano L, Zampelli N, Minopoli N, Herz NJ, Di Tullio G, Huynh T, Monfregola J, Esposito A, Cirillo C, et al.dilution for WB), Lamtor1 (CellSignaling, Cat# 8975, 1:1000 dilution for WB), Lamtor2 (CellSignaling, Cat# 8145, 1:1000 dilution for WB), VAMP3 (Novus, NB300-510, 1:1000 dilution for WB), TfR (Thermo, Cat# 13-6890

(6) Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2Nature communicationsFebruary 16, 2023Nalbach K, Schifferer M, Bhattacharya D, Ho-Xuan H, Tseng W, Williams LA, Stolz A, Lichtenthaler SF, Elazar Z, Behrends C.#ab24170/H4A3), LAMP2 (IF 1:100, Abcam, #ab25631), LAMTOR1 (Cell Signaling, #8975S), LAMTOR2 (Cell Signaling, #8145); LAMTOR3 (Cell Signaling, #8168), LC3B (Cell Signaling, #2775S), LGALS3BP (Proteintech, #10281-1-AP),

(7) Genome-wide siRNA screens identify RBBP9 function as a potential target in Fanconi anaemia-deficient head-and-neck squamous cell carcinomaCommunications biologyJanuary 13, 2023Pai G, Roohollahi K, Rockx D, de Jong Y, Stoepker C, Pennings C, Rooimans M, Vriend L, Piersma S, Jimenez CR, et al.were used. RBBP9 (Abcam, Cat# ab-157202, Santa Cruz, Cat# sc-101111), LAMTOR2 (Cell Signaling, Cat# 8145 S), PSMB2 (Enzo Life Sciences, Cat# BML-PW9300-0100), PSMC1 (Bethyl labs, Cat# A303-821A), P-ATR (S248)

(8) LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal functionThe EMBO journalMarch 1, 2022Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, Baudry M, Bi X.anti‐LAMTOR1,Sigma‐Aldrich,Cat#HPA002997; RRID:AB_1845531 Rabbit monoclonal anti‐LAMTOR2,Cell Signaling Technology,Cat#8145; RRID:AB_10971636 Rabbit monoclonal anti‐LAMTOR3,Cell Signaling Technology,Cat#8168; RRID:AB_10949501 Rabbit

(9) Leucine retention in lysosomes is regulated by starvationProceedings of the National Academy of Sciences of the United States of AmericaFebruary 8, 2022Bandyopadhyay U, Todorova P, Pavlova NN, Tada Y, Thompson CB, Finley LWS, Overholtzer M.used: anti-RagA (4357, Cell Signaling, Danvers, MA), anti-Lamtor1 (8975, Cell Signaling), anti-Lamtor2 (8145, Cell Signaling), anti-human Lamp1/CD107a (H4A3) (555798, BD Biosciences, San Jose, CA), anti-mouse

(10) Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancerCell reportsAugust 3, 2021Zaman A, Wu X, Lemoff A, Yadavalli S, Lee J, Wang C, Cooper J, McMillan EA, Yeaman C, Mirzaei H, et al.RRID:AB_10949501 LAMTOR1,Cell Signaling Technology,8175: RRID:AB_11178807 LAMTOR2,Cell Signaling Technology,8145: RRID:AB_10971636 GAPDH,Cell Signaling Technology,5174: RRID:AB_10622025 mTOR,Cell Signaling Technology,2972:

(11) Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of AmyloidosisFrontiers in immunologyJanuary 1, 2020Ma C, Hunt JB, Selenica MB, Sanneh A, Sandusky-Beltran LA, Watler M, Daas R, Kovalenko A, Liang H, Placides D, et al.antibodies were used: Anti-Liver Arginase (abcam, #ab124917), LAMTOR2 (Cell Signaling Technologies, #8145), LAMTOR3 (Cell Signaling Technologies, #8168), LAMTOR4 (Cell Signaling Technologies, #12284), RagA

(12) mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulationThe Journal of clinical investigationDecember 2, 2019Asrani K, Murali S, Lam B, Na CH, Phatak P, Sood A, Kaur H, Khan Z, Noë M, Anchoori RK, et al.(catalog 9367, Cell Signaling), 1:1000; LAMTOR1 (catalog 8975, Cell Signaling), 1:1000; LAMTOR2 (catalog 8145, Cell Signaling), 1:1000; LAMTOR3 (catalog 8168, Cell Signaling), 1:1000; RagA (catalog 4357, Cell Signaling), 1:1000;

(13) Efficient delivery of small interfering RNAs targeting particular mRNAs into pancreatic cancer cells inhibits invasiveness and metastasis of pancreatic tumorsOncotargetApril 23, 2019Taniuchi K, Yawata T, Tsuboi M, Ueba T, Saibara T.Anti-CCDC88A antibody (MABT100) was purchased from Merck Millipore (Temecula, CA, USA). Anti-LAMTOR2 antibody (8145) was purchased from Cell Signaling (Danvers, MA, USA). Anti-WASF2 (sc-33548) and anti-mTOR (sc-1549)

(14) mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTORFrontiers in cellular neuroscienceJanuary 1, 2019Sanders SS, De Simone FI, Thomas GM.Thermo Fisher Scientific, Waltham, MA, USA), mTOR (#2983, 1:1,000, CST), LAMTOR1 (#8975, 1:1,000, CST), LAMTOR2 (#8145, 1:1000, CST), LAMTOR3 (#8168, 1:1,000, CST), GAP43 (#NB300-143, 1:5,000, Novus Biologicals, Centennial,

(15) UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticityeLifeJuly 18, 2018Sun J, Liu Y, Jia Y, Hao X, Lin WJ, Tran J, Lynch G, Baudry M, Bi X.polyclonal),Sigma-Aldrich,HPA002997; RRID:AB_1845531,(1:200) Antibody,anti-p14 (rabbit monoclonal),Cell Signaling Technology,8145; RRID:AB_10971636,(1:1000) Antibody,anti-MP1 (rabbit monoclonal),Cell Signaling Technology,8168; RRID:AB_10949501,(1:1000) Antibody,anti-LAMTOR4

(16) MicroRNA-378 enhances migration and invasion in cervical cancer by directly targeting autophagy-related protein 12Molecular medicine reportsMay 1, 2018Tan D, Zhou C, Han S, Hou X, Kang S, Zhang Y.(1:2,000; cat. no. ab21699; Abcam, Cambridge, MA, USA), phosphorylated-Rb (Ser608; 1:5,000; cat. no. 8145S), ATG12 (1:2,000; cat. no. 4180T) (both from Cell Signaling Technology, Inc., Danvers, MA, USA) and

(17) LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioningThe Journal of cell biologyDecember 4, 2017Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, et al.rabbit anti-LAMP1 (WB 1:1,000, IF 1:250; HPA002997; Atlas Antibodies), rabbit anti-LAMTOR2 (WB 1:1,000; 8145; Cell Signaling), rabbit anti-LAMTOR3/MP1 (WB 1:1,000; 1525-1; Epitomics), rabbit anti-LAMTOR4 (WB 1:1,000;

(18) A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availabilityThe Journal of cell biologyDecember 4, 2017Pu J, Keren-Kaplan T, Bonifacino JS.Studies Hybridoma Bank,H4A3 LAMTOR1,Cell Signaling Technology,8975 LAMTOR2,Cell Signaling Technology,8145 LAMTOR4,Cell Signaling Technology,13140 Myc epitope,Santa Cruz Biotechnology,sc-40 Myc-HRP,Santa Cruz Biotechnology

(19) The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cellsBreast cancer research : BCRNovember 16, 2017Hromas R, Kim HS, Sidhu G, Williamson E, Jaiswal A, Totterdale TA, Nole J, Lee SH, Nickoloff JA, Kong KY.

(20) mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a NutrientCellOctober 19, 2017Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.Anti-LAMTOR1,Cell Signaling Technology,8975 Rabbit monoclonal Anti-LAMTOR2,Cell Signaling Technology,8145 Rabbit monoclonal Anti-RagA,Cell Signaling Technology,4375 Rabbit Anti-VDAC,Cell Signaling Technology,4866 Rabbit

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LAMTOR2/ROBLD3 (D7C10) Rabbit mAb

LAMTOR2/ROBLD3 (D7C10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (27)

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LAMTOR2/ROBLD3 (D7C10) Rabbit mAb from Cell Signaling Technology

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