FCRN Antibody from R&D Systems, a Bio-Techne Brand

Yes, the FCRN antibody has been utilized in studies examining the interaction between FcRn and megalin in the endosomal compartment, highlighting its role in endocytosis and intracellular trafficking. For instance, in a study by Dahlke et al. (2022), the antibody was employed in Western blotting to demonstrate the interaction of FcRn with megalin during albumin-induced endocytosis.

The FCRN antibody has shown reactivity with mouse, rat, non-human primate, and human FcRn, making it suitable for comparative studies across these species. Research by Latvala et al. (2017) confirmed its effectiveness in detecting FcRn in various tissues, indicating its broad applicability in studies involving different model organisms.

The FCRN antibody has been successfully used in immunohistochemistry to label FcRn in tissue samples, as demonstrated in studies investigating its expression in the cornea and other tissues. For example, Royer et al. (2017) utilized this antibody to assess FcRn localization in the corneal epithelium, supporting its utility in histological applications.

The FCRN antibody is significant in vaccine research as it has been shown to enhance antibody transport and efficacy in the cornea following vaccination. Royer et al. (2017) highlighted that FcRn upregulation in the cornea is crucial for improving humoral protection against ocular infections, indicating the antibody's relevance in studies focused on vaccine-mediated immunity.