AML1 (D4A6) Rabbit mAb 8529S from Cell Signaling Technology

Product Specs
ItemAML1 (D4A6) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8529S
Quantity100 µl
ApplicationsW
ReactivityH, M
TargetAML1
HostRabbit
NCBI Gene AliasesAML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha
ClonalityMonoclonal
NCBI Full Gene NameRUNX family transcription factor 1
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD4A6
Molecular Weight55

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Runx1 drives cardiac fibrosis and heart failure through epigenetic activation of myofibroblasts in pressure overload-induced cardiac remodelingBMC Cardiovasc DisordOctober 21, 2025Jun An, Wei Zhou, Lingbo Xia, Qian Wang, Xiaoping Peng, Zeqi Zheng, Xiang Wang, Yujing Zhang, Jiang Huang, Liao Geping, et al.cross-linked with 1% paraformaldehyde, sonicated, and immunoprecipitated with antibodies against Runx1 (CST, 8529 S), P300 (CST, 57625 S), IgG (CST, 3900), acetylated H3 (CST, 8173), and acetylated H4 (CST, 13534)

(2) SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residenceNature CancerSeptember 25, 2025Kaloyan M. Tsanov, Francisco M. Barriga, Yu-Jui Ho, Direna Alonso-Curbelo, Geulah Livshits, Sha Tian, Richard P. Koche, Timour Baslan, Janelle Simon, Alexandra N. Wuest, et al.(Abcam, ab137676; 1:500, IHC), KLF6 (Abcam, ab241385; 1:1,000, IHC), RUNX1 (clone D4A6, Cell Signaling, 8529; 1:500, IHC), RUNX2 (clone D1L7F, Cell Signaling, 12556; 1:500, IHC), RUNX3 (clone 2B3, Life Technologies,

(3) Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiencyInternational Journal of HematologyAugust 1, 2024Wenyu Zhang, Jingmei Li, Keita Yamamoto, Susumu Goyamafluoride membrane (Bio-Rad). The membrane was incubated with anti-RUNX1 antibody [AML1 (D4A6) Rabbit mAb #8529; Cell Signaling Technology, Beverly, MA, 1:500] and anti-GAPDH antibody [GAPDH (D16H11) XP® Rabbit mAb

(4) Metastatic site influences driver gene function in pancreatic cancerbioRxivMarch 21, 2024Kaloyan M. Tsanov, Francisco M. Barriga, Yu-Jui Ho, Direna Alonso-Curbelo, Geulah Livshits, Richard P. Koche, Timour Baslan, Janelle Simon, Sha Tian, Alexandra N. Wuest, et al.IHC), KLF5 (Abcam #ab137676, 1:500, IHC), KLF6 (Abcam #ab241385, 1:1,000, IHC), RUNX1 (Cell Signaling #8529, 1:500, IHC), RUNX2 (Cell Signaling #12556, 1:500, IHC), RUNX3 (Life Technologies #MA5–17169, 1:500,

(5) Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemiaCell reportsSeptember 21, 2021Simeoni F, Romero-Camarero I, Camera F, Amaral FMR, Sinclair OJ, Papachristou EK, Spencer GJ, Lie-A-Ling M, Lacaud G, Wiseman DH, et al.RRID:AB_2186909 anti-Myc tag,Cell Signaling,Cat#2278; RRID:AB_490778 anti-RUNX1,Cell Signaling,Cat#8529; RRID:AB_10950225 anti-STAT3,Cell Signaling,Cat#30835; RRID:AB_2798995 anti-CEBPA,Diagenode,Cat#C15410225;

(6) Runx1 shapes the chromatin landscape via a cascade of direct and indirect targetsPLOS GeneticsJune 10, 2021Matthew R. Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C. Kottyan, Matthew T. Weirauch, Raphael Kopangels and then transferred to PVDF. The primary antibodies used were as follows: Runx1 (Cell Signaling #8529), Runx2 (Cell Signaling #8486), Runx3 (Cell Signaling #9647), Zeb1 (Bethyl #a301-922a) and Beta-actin

(7) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate developmenteLifeOctober 7, 2020Mevel R, Steiner I, Mason S, Galbraith LC, Patel R, Fadlullah MZ, Ahmad I, Leung HY, Oliveira P, Blyth K, et al.Gt(ROSA)26Sortm1Hjf,C57Bl/6J background 7–15 week old males Antibody,Anti-RUNX1 (rabbit monoclonal),Cell Signaling,Cat: 8529 RRID:AB_10950225,IHC/IF (1:100) Antibody,Anti-NKX3.1 (rabbit polyclonal),Athenaes,Cat: AES-0314,IHC/IF

(8) Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital NeutropeniaCell reports. MedicineAugust 25, 2020Olofsen PA, Fatrai S, van Strien PMH, Obenauer JC, de Looper HWJ, Hoogenboezem RM, Erpelinck-Verschueren CAJ, Vermeulen MPWM, Roovers O, Haferlach T, et al.human AML1 (4334, Cell Signaling Technology) or an antibody that recognized both human and mouse AML1 (8529, Cell Signaling Technology) in whole cell lysates. CXXC4 (NBP1-76491, Novus Bio) and TET2 (ab94580,

(9) Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung AdenocarcinomaCancer cellAugust 10, 2020LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, et al.for immunoblotting: anti-Hsp90 (1:10000); BD Biosciences 610418, anti-Runx1 (1:1000), Cell Signaling Technology, 8529S, anti-Runx2 (1:1000), Cell Signaling Technology, 12556S, and anti-Runx3 (1:1000) Abcam, ab23981. Immunohistochemistry Individual

(10) Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanismeLifeApril 16, 2020Yi Kuang et al.polyclonal),Bethyl,Cat# A300-684A; RRID:AB_2266032,WB (1:1000) Antibody,anti-RUNX1 D4A6 (Rabbit monoclonal),CST,Cat# 8529; RRID:AB_10950225,WB (1:1000) Antibody,ECL anti-rabbit-HRP,GE Healthcare,Cat# NA934; RRID:AB_772206,WB

(11) The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemiaNature medicineMarch 1, 2017Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, et al.Santa-Cruz Biotechnology Lineage APC BDB558074 BD Biosciences Mac-1 PE-Cy7 101216 BioLegend RUNX1 Non Ab23980 Abcam RUNX1 Non 8529 Cell Signaling Technology Sca-1 PE-Cy7 25-5981-82 eBioscience SDHA Non 11998P Cell Signaling Technology

(12) Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCKBritish journal of cancerFebruary 28, 2017Patel GK, Khan MA, Bhardwaj A, Srivastava SK, Zubair H, Patton MC, Singh S, Khushman M, Singh AP.

(13) A rapid, automated surface protein profiling of single circulating exosomes in human bloodScientific reportsNovember 7, 2016Kibria G, Ramos EK, Lee KE, Bedoyan S, Huang S, Samaeekia R, Athman JJ, Harding CV, Lötvall J, Harris L, et al.

(14) RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancerNature CommunicationsApril 1, 2016Nyam-Osor Chimge et al.purchased from Cell Signaling Technology, Inc. and used at a 1:1,000 dilution: rabbit anti-RUNX1 (#8529), rabbit-anti-AXIN1 (#2087), rabbit anti-phospho-β-catenin (Ser33/37/Thr41; #9561) and mouse anti-CCNB1

(15) Histone H3 Lysine 36 Methyltransferase Whsc1 Promotes the Association of Runx2 and p300 in the Activation of Bone-Related GenesPLoS ONESeptember 4, 2014Yu Fei Lee, Keisuke Nimura, Wan Ning Lo, Kotaro Saga, Yasufumi Kanedaantibodies were used for western blot analysis: anti-histone H3 (1∶1000, ab1791, Abcam), anti-Runx1 (1∶500, 8529, Cell Signaling Technology), anti-Runx2 (1∶1000, 8486, Cell Signaling Technology), anti-p300 (1∶100,

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AML1 (D4A6) Rabbit mAb (Mouse Preferred)

AML1 (D4A6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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AML1 (D4A6) Rabbit mAb from Cell Signaling Technology

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