Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb 9687S from Cell Signaling Technology

Product Specs
ItemPhospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number9687S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetALK (Tyr1282/Tyr1283) phosphate
ModificationsALK (Tyr1282/Tyr1283) phosphate
HostRabbit
NCBI Gene AliasesALK1, CD246, NBLST3
ClonalityMonoclonal
NCBI Full Gene NameALK receptor tyrosine kinase
Research AreaRTK
IsotypeIgG
CloneD39B2
Molecular Weight80 (NPM-ALK), 220 (ALK)

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) GUK1 activation is a metabolic liability in lung cancerCellMarch 6, 2025Schneider JL, Kurmi K, Dai Y, Dhiman I, Joshi S, Gassaway BM, Johnson CW, Jones N, Li Z, Joschko CP, et al.Cat. # F1804), and anti-ALK (Cell Signaling Cat. # 3633S); anti-Phospho-ALK (Cell Signaling Cat. # 9687S), pY99 (pTyr) antibody (Santa Cruz Cat. # sc-7020). Anti-pY74-GUK1 was custom ordered from Phosphosolutions. GTPase

(2) NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound MutationsCancer discoveryDecember 2, 2024Lin JJ, Horan JC, Tangpeerachaikul A, Swalduz A, Valdivia A, Johnson ML, Besse B, Camidge DR, Fujino T, Yoda S, et al.Western blotting with the following antibodies (all from Cell Signaling Technology): pALK Y1282/1283 (#9687), pALK Y1604 (#3341), ALK (#3633), pAKT S473 (#4060), AKT (#4691), pERK1/2 T202/Y204 (#9101), ERK1/2

(3) Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancerNature CancerJune 20, 2022Aya Shiba-Ishii, Ted W. Johnson, Ibiayi Dagogo-Jack, Mari Mino-Kenudson, Theodore R. Johnson, Ping Wei, Scott L. Weinrich, Michele A. McTigue, Makeba A. Walcott, Linh Nguyen-Phuong, et al.dilutions. (all from Cell Signaling Technology): phospho-ALK Y1604 (3341, 1:1000), phospho-ALK Y1282/83 (9687, 1:1000), ALK (3633, 1:1000), phospho-AKT S473 (4060, 1:1000), AKT (4691, 1:1000), phospho-ERK1/2 T202/Y204

(4) Prediction of ALK Mutations Mediating ALK-TKIs Resistance and Drug Re-Purposing to Overcome the ResistanceSSRN Electronic JournalApril 2, 2022Koutaroh Okada et al.antibodies against total ALK (#3633S, Cell Signaling Technology), phospho-ALK (Y1604; #3341S, Y1282/83; #9687S, Cell Signaling), total S6 Ribosomal Protein (#2217S, Cell Signaling Technology), total p42/44 ERK/MAPK (#9102S,

(5) Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancerNature CommunicationsDecember 1, 2021Hayato Mizuta et al.Danvers, MA, USA, 1:1,000), phospho-ALK (Y1604; #3341, Cell Signaling Technology, 1:1,000, Y1282/1283; #9687, Cell Signaling Technology, 1:1000), total S6 ribosomal protein (#2217, Cell Signaling Technology, 1:1000),

(6) Alginate-based 3D cancer cell culture for therapeutic response modelingSTAR ProtocolsJune 1, 2021Farideh Davoudi, Samar Ghorbanpoor, Satoshi Yoda, Xiao Pan, Giovanna Stein Crowther, Xunqin Yin, Ellen Murchie, Aaron N. Hata, Henning Willers, Cyril H. BenesRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb,Cell Signaling Technology,Cat#9687 ALK (D5F3®) XP® Rabbit mAb,Cell Signaling Technology,Cat#3633 Phospho-Paxillin (Tyr118) Antibody,Cell Signaling Technology

(7) Preclinical Evaluation of Gilteritinib on NPM1-ALK–Driven Anaplastic Large Cell Lymphoma CellsMolecular Cancer ResearchMay 1, 2021Sudhakiranmayi Kuravi et al.(Gilteritinib-206139); Cell Signaling Technology, Beverly, MA, USA (NPM1-ALK-3333, phospho-NPM1-ALK-9687, phospho-STAT3–9145, phospho-AKT-4060, AKT-2920, ERK1/2–4695, Survivin-2802, c-Myc-5605); BD Biosciences

(8) Preclinical evaluation of gilteritinib on NPM1-ALK driven Anaplastic Large Cell Lymphoma CellsMol Cancer ResJanuary 29, 2021Sudhakiranmayi Kuravi, Janice Cheng, Gabrielle Fangman, Kishore Polireddy, Sophia McCormick, Tara L. Lin, Anurag K. Singh, Sunil Abhyankar, Siddhartha Ganguly, Danny R. Welch, et al.(Gilteritinib-206139); Cell Signaling Technology, Beverly, MA, USA (NPM1-ALK-3333, phospho-NPM1-ALK-9687, phospho-STAT3–9145, phospho-AKT-4060, AKT-2920, ERK1/2–4695, Survivin-2802, c-Myc-5605); BD Biosciences

(9) First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjectsInvestigational new drugsDecember 1, 2020Wang MN, Kuang Y, Gong LY, Hua Y, Pei Q, Guo CX, Cao Y, Huang J, Yang GP.therapies in the post-genomic era. Cancer Metastasis Rev 36(3):463–473. https://doi.org/10.1007/s10555-017-9687-8 Lemmon MA, Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141(7):1117–1134.

(10) Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistanceEBioMedicineMarch 1, 2019Koutaroh Okada et al.antibodies against total ALK (#3633S, Cell Signaling Technology), phospho-ALK (Y1604; #3341S, Y1282/83; #9687S, Cell Signaling), total S6 Ribosomal Protein (#2217S, Cell Signaling Technology), total p42/44 ERK/MAPK

(11) SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitorsNature medicineMay 1, 2018Dardaei L, Wang HQ, Singh M, Fordjour P, Shaw KX, Yoda S, Kerr G, Yu K, Liang J, Cao Y, et al.of total cell lysate were processed for immunoblotting10. Antibodies against phospho-ALK Y1282/1283 (9687), ALK (3633), phospho-AKT S473 (4060), AKT (4691), Phospho-ERK T202/Y204 (9101), ERK (9102), Phospho-Paxillin

(12) Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokinesBiochimica et biophysica acta. Molecular cell researchMarch 1, 2017Rolvering C, Zimmer AD, Kozar I, Hermanns HM, Letellier E, Vallar L, Nazarov PV, Nicot N, Ginolhac A, Haan S, et al.

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Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb

Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (12)

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Phospho-ALK (Tyr1282/1283) (D39B2) Rabbit mAb from Cell Signaling Technology

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