IRF-1 (D5E4) XP ® Rabbit mAb 8478S from Cell Signaling Technology

Product Specs
ItemIRF-1 (D5E4) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number8478S
Quantity100 µl
ApplicationsW, IP, IHC-Bond, IHC-P, IF-IC, FC-FP, C&R
ReactivityH, M, R
TargetIRF-1
HostRabbit
NCBI Gene AliasesIRF-1, MAR
ClonalityMonoclonal
NCBI Full Gene Nameinterferon regulatory factor 1
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD5E4
Molecular Weight45-48

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapyNeoplasiaApril 13, 2026Hong Lou, David Langan, Nick Syracuse, Elisabeth A. Murphy, Sojung Kim, Emma Robinson, Nicole M. Rossi, Yi Xie, Sonam Tulsyan, Tawnjerae Joe, et al.Integrin α6 (Cell Signaling Technology Cat# 3750, RRID: AB_2249263), IRF1 (Cell Signaling Technology Cat# 8478, RRID: AB_10949108) at a dilution from1:250 to 1:500; mouse monoclonal anti-HPV16 E7 at 1:100 (Santa Cruz

(2) IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itselfJournal of Experimental MedicineApril 6, 2026Aleksandr Gorin, Siyue Niu, Noa Harriott, Vyas Koduvayur, Quen J. Cheng, Alexander HoffmannpSTAT1 pY701.4A (#136229; Santa Cruz Biotechnology, RRID:AB_2019074) diluted at 1:10,000, IRF1 D5E4 (#8478; Cell Signaling Technologies, RRID:AB_10949108) diluted at 1:1,000, β-tubulin TUB2.1 (T5201; Sigma-Aldrich,

(3) Alpha-Lipoic Acid Inhibits IFN-γ-Induced PD-L1 Expression in Prostate Cancer Cells and Enhances T-Cell-Mediated Anti-Tumor CytotoxicityAntioxidants (Basel)March 25, 2026Yi-Jan Hsia, Zhang-Min Lin, Tien-Sheng Tseng, Tz-Chong Chou(Danvers, MA, USA): p-JAK1 Tyr1034/1035 (74129, 1:1000), JAK1 (3344, 1:1000), STAT1 (14994, 1:1000), IRF-1 (8478, 1:1000), mTOR (2983, 1:1000), p-p70S6K Thr389 (9205, 1:1000), p70S6K (9202, 1:1000), 4EBP1 (9644, 1:1000),

(4) MHC class I on target cells regulates CD4+ T cell-mediated immunityNature ImmunologyMarch 24, 2026Emma Lauder, Mahnoor Gondal, Meng-Chih Wu, Akira Yamamoto, Laure Maneix, Dongchang Zhao, Yaping Sun, Marcin Cieslik, Arul M. Chinnaiyan, Pavan Reddy1704151). Blots were incubated with anti-ACSL4 (Abcam, ab155282; 1:3,000), IRF1 (Cell Signaling Technology, 8478T; 1:1,000), and β-actin–horseradish peroxidase (HRP) (Cell Signaling Technology, 5152S; 1:1,000) primary

(5) AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodelingJ Immunother CancerMarch 10, 2026Chuan Liu, Chuan Hu, Jinlin Cheng, Duanfeng Xin, Sujie Jin, Weihong Tian, Shan Li, Yuzhi Jin, Yu Liu, Shuqiang Hao, et al.Proteintech, #25723-1-AP, China), GNPAT (1:1000, #ab184186, #14931-1-AP, China), IRF1 (1:1000, CST, #8478, USA), FSP1 (1:400, Proteintech, #20886-1-AP, China), and GPX4 (1:200, Abcam, #ab125066, USA). The following

(6) Orphan Nuclear Receptors expression and function in breast cancer cells: oncogenic action of the NR2F6 receptorCell Communication and SignalingMarch 9, 2026Maria Azzurra Caricasulo, Gabriela Paroni, Adriana Zanetti, Laura Brunelli, Mami Kurosaki, Andrea Vincenzo Cavallaro, Marika Foglia, Gabriella Remoli, Luca Guarrera, Marco Bolis, et al.#8242), anti-STAT1 Tyr701 (Cell Signaling Technology, #9167), anti-IRF1 (Cell Signaling Technology, #8478), anti-RIP1 Ser166 (Cell Signaling Technology, #65746), anti-RIP1 (Cell Signaling Technology, #73271),

(7) Histone demethylase JMJD1A protects mice from enteric bacterial infection by upregulating CCL8 expression to recruit macrophages and CD4+ T cellsPLoS PathogMarch 4, 2026Guifang Lin, Lichun Yang, Shuyan Jiang, Yong Zhang, Ping Luo, Weihua Li, Jianming Xu, Gongpeng Xiong, Chundong Yu, Wenbo ChenProteintech), anti-STAT1 (Cat#14994, CST), anti-phosphorylation STAT1 (Cat#9167, CST), anti-IRF-1 (Cat#8478S, CST), and anti-β-actin (Cat #A5441, Sigma-Aldrich). Partly protein band intensities were quantified

(8) Dissection of innate-immune-ligand- and interferon-protein-mediated transcriptional responses in human THP1 cell statesCommun BiolFebruary 12, 2026Lodoe Lama, Pavel Morozov, Aitor Garzia, Thomas Tuschlreagents Proteins were detected by Western blotting using antibodies from Cell Signaling Technology, IRF1 8478S, IRF7 4920S, IRF8 5628S, IRF9 76684S, STAT1 9175S, pSTAT1-Y701 9167S, pIRF3-S386 37829S, pIRF3-S396

(9) A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapymedRxivJanuary 28, 2026Hong Lou, David Langan, Nick Syracuse, Elizabeth A. Murphy, Sojung Kim, Emma Robinson, Nicole M. Rossi, Yi Xie, Sonam Tulsyan, Tawnjerae Joe, et al.Integrin α6 (Cell Signaling Technology Cat# 3750, RRID: AB_2249263), IRF1 (Cell Signaling Technology Cat# 8478, RRID: AB_10949108) at a dilution of 1:500; mouse monoclonal anti-HPV16 E7 at 1:100 (Santa Cruz Cat#

(10) The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon productionThe EMBO JournalJanuary 22, 2026Zeming Feng, Lulu Wang, Shujun Chen, Sihan Cao, Miao Lei, Xiuzhen Yang, Kaixiong Ma, Shi Yu, Huina Hu, Kaixuan Zheng, et al.(IB 1:1000),Cell Signaling Technology,#83000 (E8Z7M) IRF-1 (IB 1:1000),Cell Signaling Technology,#8478 (D5E4) IRF-4 (IB 1:1000),Cell Signaling Technology,#62834 (E8H3S) IRF-5 (IB 1:1000),Cell Signaling Technology

(11) Zinc Supplementation Partially Reconstitutes Impaired Interferon-γ Production in the ElderlyInternational Journal of Molecular SciencesJanuary 20, 2026Krisztina Olah, Johanna Zenk, Jana Jakobs, Thea Laurentius, Leo Cornelius Bollheimer, Lothar Rinkmembrane was incubated with a 1:500 solution of monoclonal rabbit primary antibodies (β-actin #4967, IRF1 #8478, and IRF3 #4302; all from Cell Signaling Technology, Leiden, The Netherlands; Zip8 #20459-1-AP, Proteintech,

(12) Targeting PTPN13 with 11-amino-acid peptides of C-terminal APC prevents immune evasion of colorectal cancerCell ResJanuary 5, 2026Wen-Hui Ma, Wen-Yi Li, Tao Chen, Linqian Jing, Yue-Hong Chen, Kejun Li, Zhuo-Luo Xu, Rong-Fang Shen, Yutong He, Tingyu Mou, et al.Cell Signaling Technology), anti-STAT1 (1:500, #9172S, Cell Signaling Technology), anti-IRF1 (1:500, #8478S, Cell Signaling Technology), anti-Caspase-8 monoclonal antibody (1:500, 66093-1-IG-50UL, Proteintech),

(13) Distinct regulatory elements of SLC6A14 expression contribute to modification of cystic fibrosis phenotypesHum GenetJanuary 5, 2026Mohsen Esmaeili, Cheng Wang, Fan Lin, Naim Panjwani, Adele Chan, Gengming He, Katherine Keenan, Julie Avolio, Ann Harris, Johanna M. Rommens, et al.antibodies used for immunodetection included SLC6A14 (Atlas Antibodies, HPA003193), IRF1 (Cell Signaling, 8478), IRF2 (Invitrogen, PA584335) and Calnexin (MilliporeSigma, C4731). Horseradish peroxidase-conjugated

(14) Overexpression of JMJD6 drives immune evasion via the BRD4–IRF1–PD-L1 axis and promotes malignancy in gastric cancerScientific ReportsDecember 8, 2025Ryo Ishida, Shuhei Komatsu, Hajime Kamiya, Takuma Ohashi, Taisuke Imamura, Jun Kiuchi, Keiji Nishibeppu, Yusuke Takashima, Hiroshi Arakawa, Masateru Yamauchi, et al.polyclonal antibody (A301-985A50; Bethyl Laboratories, TX, USA), and anti-IRF1 rabbit monoclonal antibody (8478; Cell Signaling Technology) were used. Cells were lysed, and their proteins were extracted using M-PER® Mammalian Protein Extraction Reagent

(15) MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondriaThe FEBS JournalDecember 5, 2025Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela RibeiroDanvers, MA, USA), GFP (#2956, Cell Signaling), MAVS (sc‐166 583, Santa Cruz Biotechnology), IRF1 (#8478, Cell Signaling), viperin (MABF106, MilliporeSigma), α‐Tubulin (T9026, Sigma‐Aldrich), β‐Actin (#3700,

(16) Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapyCell Reports MedicineNovember 18, 2025Po-Hsien Chiu, Kuan-Chen Lai, Hung-Ling Wang, Yao-Wen Chang, Wen-Chi Wu, Tien-Hua Chen, Yu-Shuen Tsai, Jie-Hong Song, Nai-Yun Sun, Gar-Yang Chau, et al.,Cell Signaling Technology,Cat# 8826;RRID: AB_2773718 Rabbit monoclonal IRF-1 (D5E4) XP®,Cell Signaling Technology,Cat# 8478;RRID: AB_10949108 Rabbit recombinant monoclonal PD-L1 (E1L3N®) XP®,Cell Signaling Technology,Cat# 13684;RRID:

(17) ST6GAL1-mediated sialylation inhibits the antitumor immune response in colorectal cancerCell Oncol (Dordr)November 11, 2025Yuanchao Shi, Zhihong Peng, Zhenzhong Pan, Jingwei Duan, Zexing Wang, Quanlin Guan, Yiliang Fang, Bo Tang1:1000), anti-STAT1 (CST, 9172 S, 1:1000), anti-p-STAT1 (Tyr701, CST, 9167 S, 1:1000), anti-IRF-1 (CST, 8478 S, 1:1000), anti-GBP1 (Affinity, DF3598, 1:1000), anti-GAPDH (CST, 2118 S, 1:2000), and anti-BICD2 (Abcam,

(18) IRF7 drives macrophages to kill bacteria and improves septic outcomes via autophagyJCI InsightNovember 10, 2025Guiming Chen, Kangxin Li, Haihua Luo, Lianxu Zhao, Yong Jiangmembranes. The membranes were incubated with primary antibodies against IRF1 (Cell Signaling Technology, 8478, 1:1,000), IRF2 (Cell Signaling Technology, 76647, 1:1,000), IRF3 (Cell Signaling Technology, 11904,

(19) Tumoral ALOX5 mediated arachidonic acid metabolism regulates immune response in non-small cell lung cancerCell Oncol (Dordr)November 5, 2025Yuan Gao, Yangchen Xia, Jiayao Li, Yongfeng Lai, Songlin Yin, Junhong Lin, Dongrunhan Yu, Shanshan Huang, Fujia Lu, Weimin Wang, et al.sc-47778, santa curz; anti-Flag, F1408, Sigma; anti-p-JAK1, 74129, CST; anti-pSTAT1, 8826, CST; anti-IRF1, 8478, CST; anti-GAPDH, 60004-1-Ag, Proteintech; followed by 1 h at room temperature with HRP-conjugated secondary

(20) Dasatinib inhibits PD-L1 expression via a proteasomal pathway in pancreatic ductal adenocarcinoma cellsJournal of CancerNovember 5, 2025Ching-Chung Ko, Hui-Ying Li, Pei-Ming Yang(#GTX100118) antibodies were obtained from GeneTex (Hsinchu, Taiwan). Interferon regulatory factor 1 (IRF1) (#8478) and phospho-Tyr705-signal transduction and activator of transcription 3 (STAT3) (#9145) antibodies

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IRF-1 (D5E4) XP ® Rabbit mAb

IRF-1 (D5E4) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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IRF-1 (D5E4) XP ® Rabbit mAb from Cell Signaling Technology

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