Stat6 (D-1) Antibody sc-374021 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemStat6 (D-1) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-374021
Quantity200 µg/ml
CloneD-1
Conjugate/TagUnconjugated
ClonalityMonoclonal
Hostmouse
Reactivitymouse, rat, human
Antibody TypePrimary Antibodies
ApplicationsWB, IP, IF, IHC(P), ELISA
NCBI Gene AliasesSTAT6B, D12S1644, IL-4-STAT, STAT6C
NCBI Full Gene Namesignal transducer and activator of transcription 6
TargetStat6
FormatPurified
IsotypeIgG2b

Questions and Answers

Can this antibody be used to study the role of STAT6 in uveal melanoma?

Yes, the Stat6 (D-1) antibody has been shown to work in Western blot analyses to investigate the expression of STAT6 in uveal melanoma cell lines. In a study, it was demonstrated that STAT6 contributes to the expression of the serotonin receptor 2B (HTR2B), which is associated with metastatic progression in uveal melanoma ().

Is the Stat6 (D-1) antibody effective for immunohistochemistry applications?

The Stat6 (D-1) antibody has been utilized in immunohistochemical staining, as evidenced by its application in studies examining tissue samples for STAT6 expression, which is relevant in various cancer contexts, including solitary fibrous tumors ().

How does the Stat6 (D-1) antibody perform in Western blotting?

The Stat6 (D-1) antibody has been cited in multiple studies for its effectiveness in Western blotting to detect STAT6 protein levels. For instance, it has been used to analyze the phosphorylation status of STAT6 in response to interleukins in various cell types, indicating its utility in signaling pathway studies (, ).

What specific applications has the Stat6 (D-1) antibody been used for in research?

The Stat6 (D-1) antibody has been applied in various research contexts, including Western blotting, immunofluorescence, and immunoprecipitation, to study its role in signaling pathways related to inflammation, cancer progression, and metabolic regulation (, ).

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Investigate the co-culture effects of BM-mesenchymal stem cells on the promotion of apoptotic pathways of CD34 + leukemic stem cellsBioImpactsAugust 25, 2025Mei Ding, Chuanhua Jiaincubated with primary polyclonal antibodies (1:1000) against β-actin (sc-47778), BCLX (sc-8392), STAT6 (sc-374021), p-STAT6 (sc-136019), C-EBP (sc-150), C-Myc (sc-40), P16 (sc-377412), P21 (sc-6246), P38 (sc-535),

(2) STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary FibrosisAdvanced ScienceJuly 17, 2025Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Taoantibodies overnight at 4 °C. Primary antibodies against PTGS‐2 (sc‐376861), FTH‐1 (sc‐376594), STAT6 (sc‐374021), p‐STAT6 (sc‐136019), Parkin (sc‐32282), Pink1 (sc‐518052), LC3 (sc‐398822), Epcam (sc‐53532), β‐actin

(3) miR-1226-5p is involved in radioresistance of colorectal cancer by activating M2 macrophages through suppressing IRF1Journal of Translational MedicineOctober 29, 2024Jae Yeon Choi, Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, Incheol Shin, In Hwa BaeTWIST (ab50887), N-cadherin (ab18203), and γ-H2AX (ab11174) were purchased from Abcam (UK). STAT6 (sc-374021) and β-actin (sc-47778) were obtained from Santa Cruz Biotechnology (TX, USA). Horseradish peroxidase

(4) Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophilsbioRxivAugust 24, 2024Ravi Gautam, Megha Lal, Margaret C. Carroll, Zoe Mrozek, Tina Trachsel, Jarad Beers, Melanie A. Ruffner0.2 μm PVDF, blocked, and incubated overnight at 4°C in primary antibody (mouse anti-STAT6 1:1000, sc-374021, Santa Cruz Biotechnology; rabbit anti-pSTAT6 1:1000, SAB4300038, Sigma-Aldrich; mouse anti-DSG1, 1:1000,

(5) Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic ModulationInternational Journal of Molecular SciencesApril 24, 2024Demond Williams, Ebony Hargrove-Wiley, Wendy Bindeman, Daniel Valent, Adam X. Miranda, Jacob Beckstead, Barbara Fingleton#13390S), B-Actin (Cell Signaling Technology #5125S), STAT6 (Santa Cruz Biotechnology, Dallas, TX, USA, sc-374021), H3K9ac (Active Motif, Carlsbad, CA, USA, #91103), H3K27ac (Active Motif #39133), and Histone H3 (Active Motif

(6) JAK/STAT blockade reverses the malignant phenotype of Hodgkin and Reed-Sternberg cellsBlood advancesAugust 8, 2023Fernández S, Solórzano JL, Díaz E, Menéndez V, Maestre L, Palacios S, López M, Colmenero A, Estévez M, Montalbán C, et al.

(7) Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancerJournal of pharmaceutical analysisJuly 1, 2023Sun X, Zhou L, Wang Y, Deng G, Cao X, Ke B, Wu X, Gu Y, Cheng H, Xu Q, et al.

(8) A20 is a master switch of IL-33 signaling in macrophages and determines IL-33-induced lung immunityThe Journal of allergy and clinical immunologyJuly 1, 2023Holgado A, Liu Z, Aidarova A, Mueller C, Haegman M, Driege Y, Kreike M, Scott CL, Afonina IS, Beyaert R.

(9) PD‑L1 mediates triple‑negative breast cancer evolution via the regulation of TAM/M2 polarizationInternational journal of oncologyDecember 1, 2022Meng Z, Zhang R, Wu X, Zhang M, Jin T.Ltd.), p-STAT6 (1:1,000; cat. no. 56554; CST Biological Reagents Co., Ltd.), STAT6 (1:1,000; cat. no. sc-374021; Santa Cruz Biotechnology, Inc.), p-STAT3 (1:1,000; cat. no. 9145; CST Biological Reagents Co., Ltd.),

(10) Nuclear transport of STAT6 determines the matrix rigidity dependent M2 activation of macrophagesBiomaterialsNovember 1, 2022Kim JK, Han SB, Park SI, Kim IS, Kim DH.

(11) STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathwayCell death & diseaseJune 6, 2022Yang Y, Ma Y, Li Q, Ling Y, Zhou Y, Chu K, Xue L, Tao S.TrichostatinA (TSA, S1045) was purchased from Selleck (Shanghai, China). Primary antibodies against STAT6 (sc-374021), p-STAT6 (sc-136019), PTGS-2 (sc-52972), P53 (sc-126), P21 (sc-6246), CBP (sc-32244), HA (sc-7392),

(12) CD13 is a useful tool in the differential diagnosis of meningiomas with potential biological and prognostic implicationsVirchows Archiv : an international journal of pathologyJune 1, 2022Marletta S, Luchini C, Sperandio N, Torresani E, Sorio A, Girolami I, Scarpa A, Eccher A, Ghimenton C.

(13) Expanding the spectrum of PLAG1-rearranged lipoblastomas arising in patients over 45, with identification of novel fusion partnersModern pathology : an official journal of the United States and Canadian Academy of Pathology, IncFebruary 1, 2022Brčić I, Igrec J, Halbwedl I, Viertler C, Liegl-Atzwanger B.

(14) Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal MelanomaInternational journal of molecular sciencesJanuary 29, 2022Benhassine M, Le-Bel G, Guérin SL.Santa Cruz Biotechnology), Total STAT5 (sc-74442 (monoclonal), 1/100; Santa Cruz Biotechnology), Total STAT6 (sc-374021 (monoclonal), 1/100; Santa Cruz Biotechnology), HTR2B (HPA-012867 (monoclonal), 1/100; Millipore Sigma),

(15) STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidationCell death & diseaseJanuary 19, 2022Li J, Yang Y, Li Q, Wei S, Zhou Y, Yu W, Xue L, Zhou L, Shen L, Lu G, et al.SDS-polyacrylamide gel and subjected to immunoblot analysis. The following antibodies were used: STAT6 (sc-374021), p-STAT6 (sc-136019), Arg-1 (sc-166920), TGF-β (sc-146), α-SMA (sc-53142), FN (sc-18827), H3 (sc-517576),

(16) STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling PathwayOxidative medicine and cellular longevityJanuary 1, 2022Yang Y, Li Q, Wei S, Chu K, Xue L, Liu J, Ma Y, Tao S.Cell Culture The primary antibodies purchased from Santa Cruz Biotechnology are specified as follows: anti-STAT6: sc-374021, anti-p-STAT6: sc-136019, anti-Nrf2: sc-13032, anti-NQO1: sc-32793, anti-VDR: sc-13133, anti-CYP24A:

(17) m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosisFrontiers in immunologyJanuary 1, 2022Yang Y, Li Q, Ling Y, Leng L, Ma Y, Xue L, Lu G, Ding Y, Li J, Tao S.group were separated through an SDS-polyacrylamide gel. The following antibodies were used: STAT6 (sc-374021), p-STAT6 (sc-136019), Arg-1 (sc-166920), TGF-β1 (sc-146), α-SMA (sc-53142), FN (sc-18827), LC3I/II

(18) Fascin-1 is associated with recurrence in solitary fibrous tumor/hemangiopericytomaMolecular and clinical oncologyOctober 1, 2021Yamamoto Y, Hayashi Y, Sakaki H, Murakami I.examination was performed using a Ventana automated system with the following antibodies: STAT6 (D-1, sc-374021, dilution 1:50; Santa Cruz Biotechnology, Inc.), Ki-67 (MIB-1, dilution 1:50; Dako; Agilent Technologies,

(19) Expression of STAT6 and Phosphorylated STAT6 in Primary Central Nervous System LymphomasJournal of neuropathology and experimental neurologySeptember 27, 2021Karpathiou G, Ferrand E, Camy F, Babiuc SM, Papoudou-Bai A, Dumollard JM, Cornillon J, Peoc'h M.

(20) MiR-342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell deathEMBO reportsSeptember 6, 2021Fu B, Lin X, Tan S, Zhang R, Xue W, Zhang H, Zhang S, Zhao Q, Wang Y, Feldman K, et al.

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Stat6 (D-1) Antibody

Stat6 (D-1) Antibody from Santa Cruz Biotechnology, Inc.

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Stat6 (D-1) Antibody from Santa Cruz Biotechnology, Inc.

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