Fig 1: Ligand‐receptor (LR) network analysis of crosstalk among DCs, HPC‐like cells, malignant cells and macrophage. (A) Heatmap showing DEGs in HNSCC patients who received immunotherapy. (B) Association between LILRB1 and CXCL13 expression in HNSCC (n = 522). (C) Histogram visually displaying differential expression of CXCL13 and CXCR5 between LILRB1high (n = 247) and LILRB1low (n = 248) HNSCC patients. (D) The left UMAP plot showing the distribution of cell subsets (CD8‐SLC4A10‐MAIT and CD8‐PDCD1) integrated from single‐cell data that were retrieved from GSE103322. Two UMAP plots showing expression distribution of CXCL13 in CD8‐PDCD1 and CXCR5 in CD8‐SLC4A10‐MAIT (right). (E) Histogram visually displaying differential expression of CD8A between LILRB1high (n = 247) and LILRB1low (n = 248) HNSCC patients. (F) Histogram visually displaying differential expression of SPP1, ACP5, CD44, and CXCR5 between CXCL13 high (n = 247) and CXCL13 low (n = 248) HNSCC patients. ****, p < 0.0001.