Fumarase (D9C5) Rabbit mAb 4567T from Cell Signaling Technology

Product Specs
ItemFumarase (D9C5) Rabbit mAb
CompanyCell Signaling Technology
Price $153.00 Inquire
Catalog Number4567T
ClonalityMonoclonal
ReactivityH, M, R, Hm, Mk
ApplicationsW, IHC-P
HostRabbit
Quantity20 µl
TargetFumarase
NCBI Full Gene Namefumarate hydratase
NCBI Gene AliasesFMRD, HLRCC, HsFH, LRCC, MCL, MCUL1

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Senescent Fibroblasts Drive Melanoma Progression Through GCP ‐2 Induced CREB Phosphorylation Enhancing GlycolysisAging CellNovember 19, 2025Abhijit Basu, Vida Farsam, Karmveer Singh, Diana Crisan, Nicolai Treiber, Lars Alexander Schneider, Margit Huber, Jennifer I. Engelmeyer, Björn Schumacher, Pallab Maity, et al.#13064; G3PDH #2118; PDH #3205; IDH1 #8137, IDH2 #12652; OGDH #13407; GDH1/2 #12793; SDH #11998; FH #4567; Cell Signalling Technologies) were diluted 1:1000 in 3% SKMT and incubated overnight at 4°C. Visualization

(2) NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ DepletionMolecular cancer research : MCROctober 2, 2024Noronha KJ, Lucas KN, Paradkar S, Edmonds J, Friedman S, Murray MA, Liu S, Sajed DP, Sachs C, Spurrier J, et al.(Cell Signaling Technology, Cat. # 13901, RRID:AB_2728768, 1:1,000), Fumarase (Cell Signaling Technology, Cat. # 4567, RRID:AB_11178522, 1:1,000), NAPRT (Proteintech, Cat. # 66159-1-Ig, RRID:AB_2881555, 1:3,000), NAMPT

(3) CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunctionAging (Albany NY)March 31, 2024Alcir L. Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, Pamela MaherLDH-A phosphorylated at tyrosine 10 (#8176), PFKFB3 (#13123), TXNIP (#14715), MAL-K (#14942), FH (#4567) were from Cell Signaling (Danvers, MA, USA); Nrf1 (#175932), TFAM (#131607), mitochondrial electron

(4) Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogateCommunications biologyMarch 7, 2024Chen C, Li H, Zhang J, Cheng SC.anti-pyruvate dehydrogenase (PDHA, #3205, Cell signaling technology, 1:1000), anti-fumarate hydratase (FH, #4567, Cell signaling technology, 1:1000), anti-citrate synthase (CS, #14309, Cell signaling technology, 1:1000),

(5) FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney CancerCancer DiscoverySeptember 6, 2023Blake R. Wilde, Nishma Chakraborty, Nedas Matulionis, Stephanie Hernandez, Daiki Ueno, Michayla E. Gee, Edward D. Esplin, Karen Ouyang, Keith Nykamp, Brian Shuch, et al.(Cell Signaling Technology Cat# 2956, RRID:AB_1196615; dilution 1:1000), FH (Cell Signaling Technology Cat# 4567, RRID:AB_11178522; dilution 1:1000), v5-HRP (Thermo Fisher Scientific Cat# R961–25, RRID:AB_2556565;

(6) A Single-Blind Randomized Control Trial on the Effectiveness of Adjunct Cognitive Stimulation Therapy on Cognitive Outcomes in DementiaAnnals of Indian Academy of NeurologyApril 17, 2023Soumya Bhowmik, Mina Chandra, Kuljeet Anand, Shrishti Dahujaalready documented the significant impact of CST on various cognitive outcomes in dementia patients.[4567] However, CST has not been explored as an adjunct intervention for the management of dementia in low-

(7) P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilizationJournal of translational medicineFebruary 20, 2023Sheng G, Gao Y, Ding Q, Zhang R, Wang T, Jing S, Zhao H, Ma T, Wu H, Yang Y.(ab137773, Abcam), anti-SUCLG1 (ab97867, Abcam), anti-SDHA (#11998, Cell Signaling Technology), anti-FH (#4567, Cell Signaling Technology), anti-CDK4 (#12790, Cell Signaling Technology), anti-PCNA (#2586, Cell Signaling Technology

(8) dTMP imbalance through thymidylate 5'-phosphohydrolase activity induces apoptosis in triple-negative breast cancersScientific reportsNovember 21, 2022Kim DH, Kim JS, Mok CS, Chang EH, Choi J, Lim J, Kim CH, Park AR, Bae YJ, Koo BS, et al.(Cell signaling technology, 3582), SDHA (Cell signaling technology, 11998), Fumarase (Cell signaling technology, 4567), Citrate Synthase (Cell signaling technology, 14309), ACO2 (Cell signaling technology, 6571), IDH2

(9) Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step ModelCancers (Basel)November 9, 2022Balakrishnan Solaimuthu, Michal Lichtenstein, Arata Hayashi, Anees Khatib, Inbar Plaschkes, Yuval Nevo, Mayur Tanna, Ophry Pines, Yoav D. Shaulexonic regions were kept. 2.4. Antibodies Antibodies were obtained from the following sources: FH (#4567) and Phospho-Histone H2A.X-Ser139 (20E3 (#9718), p-STAT3-Tyr705 (#9145), STAT3 (#9139), Rabbit β-actin

(10) Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liveriScienceApril 15, 2022Yamada T, Murata D, Kleiner DE, Anders R, Rosenberg AZ, Kaplan J, Hamilton JP, Aghajan M, Levi M, Wang NY, et al.BD Biosciences), MFF (Gandre-Babbe and van der Bliek, 2008), IDH2 (56439; Cell Signaling Technology), Fumarase (4567; Cell Signaling Technology), SDHA (11998; Cell Signaling Technology), SDHB (ab14714; Abcam), SDHC (14575-1-AP;

(11) Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in miceCell death & diseaseMarch 29, 2022Zhang Y, Chen Y, Zhang Z, Tao X, Xu S, Zhang X, Zurashvili T, Lu Z, Bayascas JR, Jin L, et al.anti-GAPDH (CST, 8844), anti-Ehhadh (Santa Cruz, sc-393123), TOP3B (Santa Cruz, sc-137238), anti-FH (4567, CST), anti-G6PD (12263, CST), anti-HK2 (2867, CST), anti-Flag (CST, 8146), and anti-Myc (CST, 2278). Statistics Data

(12) Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapyOncotargetJanuary 1, 2022Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, et al.horseradish-peroxidase linked secondary antibody at 1:5,000–10,000 dilution. Antibodies used include the FH antibody (#4567S Cell Signaling Technology), GAPDH antibody (#3683 Cell Signaling Technology or ProteinTech #HRP-60004),

(13) Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion riskNature communicationsJune 8, 2021Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, et al.anti-SDHB (1:1000; 10620-1-AP; Proteintech), anti-SDHC (1:1000; 14575-1-AP; Proteintech), anti-FH (1:1000; #4567; CST), anti-MDH2 (1:1000; 15462-1-AP; Proteintech), anti-HIF1a (1:500; #36169; CST), anti-IL-1β (1:1000;

(14) Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cellsScientific ReportsDecember 1, 2020Shingo Noguchi, Hirokazu Ishikawa, Kenichi Wakita, Fumio Matsuda, Hiroshi Shimizudetected with LAS4000 (Fujifilm Corporation). The antibodies used were as follows: FH, rabbit monoclonal (#4567; Cell Signaling Technology Inc.); β-actin, rabbit monoclonal (#4970; Cell Signaling Technology Inc.);

(15) ACCELERATE MULTIPLE SEQUENCE ALIGNMENT BY CLUSTER ALGORITHM USING RECONFIGURABLE HARDWAREJournal of Al-Azhar University Engineering SectorJuly 19, 2020Asmaa Seliem, Hesham A.Hamed, Wael AbouElWafaFPE‫ارز‬IO=‫ ا‬F4‫د‬IKL:=‫ ا‬FGH‫ا‬IJ ‫د‬9:;<=‫? ا‬6@6;=‫ذاة ا‬CDE 34567 ٢ &7‫ل أ<و ا=و‬:‫ و وا‬،١‫&'د‬5 4567 ‫&م‬2‫ و ھ‬،١*‫م‬-.( ‫'&ل‬+ ‫أ('&ء‬ >?@ ،ABCDE‫ ا‬، ‫ا‬ ، ‫ا د‬ ، ‫ ما د ا ر‬١ >?@ ،ABCDE‫ ا‬، ‫ا‬ ،

(16) Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyteFree radical biology & medicineFebruary 20, 2020Manuel AM, Walla MD, Dorn MT, Tanis RM, Piroli GG, Frizzell N.(sc-1616) was from Santa Cruz Biotechnology Inc. (Dallas, TX). Polyclonal antibodies against fumarase (#4567), Keap1 (#4617), cleaved caspase 3 (#9664), and the monoclonal recognizing citrate synthase (#14309)

(17) SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2Nature ImmunologyOctober 1, 2019Anne-Valérie Burgener et al.anti-MTCO2 mAb (ab110258) and anti-Tomm20 mAb(ab56783)(all from Abcam), anti-SDHA mAb (119989), anti-FH mAb (4567), anti-KEAP1 mAb (8047), anti-Nrf2 pAb (12721), panmethyl-histone H3 (Lys9) mAb (4473) and anti-β-actin

(18) Role of Mitochondria in FerroptosisMolecular CellJanuary 1, 2019Minghui Gao, Junmei Yi, Jiajun Zhu, Alexander M. Minikes, Prashant Monian, Craig B. Thompson, Xuejun JiangRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies γ-tubulin,Sigma,Cat# T6557 Tom20,Santa Cruz,Cat#SC11415 Tim23,Cell Signaling,Cat# 3130S Fumarase,Cell signaling,Cat#4567S Vinculin,Cell signaling,Cat#13901S Chemicals and Reagents,Chemicals and Reagents,Chemicals and Reagents erastin,Sigma,Cat#E7781 RSL3,Selleckchem,Cat#

(19) Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis inductionCancer scienceSeptember 1, 2018Kerins MJ, Milligan J, Wohlschlegel JA, Ooi A.antibodies used for immunoblotting were as follows: ACTB (Millipore‐Sigma A1978), FH (Cell Signaling 4567, Danvers, MA, USA), Flag (Cell Signaling 8146), GPX4 (Abcam 41787, Cambridge, MA, USA), 2‐succinylcysteine

(20) Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumorCell death discoveryJanuary 1, 2018Zhou X, Xu M, Zeng W, Chen Z, Lu G, Gong Y, Finnell RH, Xiao H, Qiao B, Wang H.of the following primary antibodies in either 5% non-fat milk or 5% bovine serum albumin: anti-FH (#4567), anti-G6PD (# 12263), and anti-HIF-1A (# 3716) from CST (Cell Signaling Technology); as well as anti-PFKM

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Fumarase (D9C5) Rabbit mAb from Cell Signaling Technology

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Fumarase (D9C5) Rabbit mAb from Cell Signaling Technology

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