Fig 1: (a) Structural analysis of the two SMARCB1 containing SWI/SNF subfamilies, cBAF and PBAF, showing SMARCB1 is proximal to the nucleus. (b) PBAF cryo-EM structure (PDB: 7Y8R) of WHD binding to DNA with residue averaged z-score overlaid. (c) Interaction of RPT2 domain of SMARCB1 with DPF2 as described in the cryo-EM structure of cBAF (PDB: 6LTJ). (d) SMARCB1 transcript abundance for each condition as assessed through bulk RNA-seq after 8 days of induction with 1μg/mL doxycycline induction. ***P value < 0.0005 from differential expression analysis using DESeq2. (e) Close interaction of residues W281 and I315R with residue averaged z-score overlaid on AlphaFold predicted structure of SMARCB1.