Fig 2: Prognostic role of three hallmark genes (POU2F2, CD2, CST7) in NSCLC. (a) Venn diagram of differentially expressed genes in GSE139555, GSE127465, GSE126044, and GSE135222. (b) Kaplan-Meier survival curves illustrating the prognostic implications of POU2F2 in NSCLC. (c) Kaplan-Meier survival curves illustrating the prognostic implications of CD2 in NSCLC. (d) Kaplan-Meier survival curves illustrating the prognostic implications of CST7 in NSCLC. (e) Kaplan-Meier survival curves illustrating the prognostic implications of POU2F2+ B cells in NSCLC. (f) Kaplan-Meier survival curves illustrating the prognostic implications of CD2+ B cells in NSCLC. (g) Kaplan-Meier survival curves illustrating the prognostic implications of CST7+ B cells in NSCLC.

Fig 3: POU2F2 is highly expressed in tumor infiltration B cell. (a,b) UMAP plots showing different cell types and the expression of POU2F2, CD2, and CST7 in LUAD scRNA-seq datasets (GSE139555, GSE127465). (c,d) mIHC images showing the colocalization of POU2F2 and CD20 in LUAD (c) and LUSC (d). Scale bar: 100 μm, 20 μm. (e) Violin plot showing B cell groups based on POU2F2 expression levels. (f) GO enrichment analysis results for B cells with differential POU2F2 expression. g) KEGG enrichment analysis results for B cells with differential POU2F2 expression.