HXK II (B-8) Antibody sc-374091 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemHXK II (B-8) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-374091
Quantity200 µg/ml
Reactivityhuman
Conjugate/TagUnconjugated
ClonalityMonoclonal
CloneB-8
Antibody TypePrimary Antibodies
NCBI Gene AliasesHKII, HXK2
ApplicationsWB, IP, IF, IHC(P), ELISA
Hostmouse
NCBI Full Gene Namehexokinase 2
TargetHXK II
FormatPurified
IsotypeIgG2a

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Tankyrases modulate the hypoxia response through non-catalytic mechanisms affecting HIF-1αCell Communication and SignalingNovember 5, 2025Esteban Zamudio-Martínez, Daniel Delgado-Bellido, Jerónimo Borrego-Pérez, Angel Garcia-Diaz, Ana Belén Herrera-Campos, José Manuel Rodríguez-Vargas, F. Javier Oliveranti-BNIP3 (559690, BD Pharmingen), anti-CA9 (NB100-417, Novus), anti-HIF-1α (NB100-479, Novus), anti-HK2 (sc-374091, Santa Cruz), anti-K48 linkage polyubiquitin (4289, Cell Signalling), anti-LC3 (PD014, MBL), anti-PFKFB4

(2) An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunctionMol Ther Nucleic AcidsJune 10, 2025Ane Olazagoitia-Garmendia, Henar Rojas-Márquez, Tim Trobisch, Cristina Moreno-Castro, Ariadne Rodriguez Etxebarria, Jon Mentxaka, Ajai Tripathi, Bibo Yang, Itziar Martin Ruiz, Juan Anguita, et al.for western blotting: YTHDC1 (Abcam, #264375, Cell Signaling, #E4I9E), HK2 (Santa Cruz Biotechnologies, #sc-374091), HSP90 (Cell Signaling; #4874), CYTC (Santa Cruz Biotechnologies, #sc-13156), GAPDH (Santa Cruz Biotechnologies,

(3) CAVPENET Peptide Inhibits Prostate Cancer Cells Proliferation and Migration through PP1γ-Dependent Inhibition of AKT SignalingPharmaceuticsSeptember 12, 2024Bárbara Matos, Antoniel A. S. Gomes, Raquel Bernardino, Marco G. Alves, John Howl, Carmen Jerónimo, Margarida Fardilhaanti-p(Thr37/46)-4E-BP1 (rabbit, 1:1000, 236B4, Cell Signaling), anti-4E-BP1 (rabbit, 1:1000), anti-HK2 (mouse, 1:500, sc-374091, Santa Cruz Biotechnologies), anti-FASN (mouse, 1:500, sc-55580, Santa Cruz Biotechnologies); anti-CD36

(4) Metabolic and Oxidative Stress Management Heterogeneity in a Panel of Breast Cancer Cell LinesMetabolitesAugust 6, 2024Maycotte P, Sarmiento-Salinas FL, García-Miranda A, Ovando-Ovando CI, Robledo-Cadena DX, Hernández-Esquivel L, Jasso-Chávez R, Marín-Hernández A.(SC-376421), CAT (SC-365738), CS (citrate synthase, SC-390693), GR (SC-133245), HKII (hexokinase II, SC-374091), SOD 2 (SC-130345, Santa Cruz Biotechnology TX, USA), SOD 1 (MA1105, Thermo Fisher, Waltham MA, USA),

(5) Effects of short-term exercise and endurance training on skeletal muscle mitochondria damage induced by particular matter, atmospherically relevant artificial PM2.5Frontiers in public healthJanuary 1, 2024Liu W, Wang Z, Gu Y, So HS, Kook SH, Park Y, Kim SH.Abcam,); GLUT4 (sc-53566, Santa Cruz Biotecnology, CA, USA); Hexokinase 2 (HK2, Santa Cruz Biotecnology, sc-374091); phosphofrucokinase (PFK, sc-166722, Santa Cruz Biotecnology), lactate dehydrogenase (LDH, sc-133123,

(6) Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid OxidationAntioxidants (Basel, Switzerland)November 2, 2023Giuliani A, Giudetti AM, Vergara D, Del Coco L, Ramini D, Caccese S, Sbriscia M, Graciotti L, Fulgenzi G, Tiano L, et al.Santa Cruz Biotechnology, Dallas, TX, USA), LDH-A (1:1000, sc-137243, Santa Cruz Biotechnology, USA), HK-II (1:1000, sc-374091, Santa Cruz Biotechnology, USA), NF-κB p65 (1:1000 C22B4 #4764 Cell Signaling Technologies, Danvers,

(7) 4EBP2-regulated protein translation has a critical role in high-fat diet–induced insulin resistance in hepatocytesJournal of Biological ChemistryNovember 1, 2023Xiao Han, Fei Yang, Zhengyi Zhang, Zhanwu Hou, Qiong Sun, Tian Su, Weiqiang Lv, Zhen Wang, Chao Yuan, Guanfei Zhang, et al.(Ser473) 4060, Cell Signaling Technology; Phospho-GSK-3β (Ser9), 5558, Cell Signaling Technology; HK2, sc-374091, Santa Cruz Biotechnology; 4EBP2, 2845, Cell Signaling Technology; GAPDH, AC002, ABclonal; G6PD, sc-373886,

(8) IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotypeBiology directJuly 27, 2023Soussi S, Savchenko L, Rovina D, Iacovoni JS, Gottinger A, Vialettes M, Pioner JM, Farini A, Mallia S, Rabino M, et al.,Santa Cruz Biotechnology,sc-33697 Dystrophin,Abnova,630-170 Dystrophin,Thermofisher,PA5-16734 DRP1,Abcam,ab184247 HK1,Santa Cruz Biotechnology,sc-46695 HK2,Santa Cruz Biotechnology,sc-374091 HSP60,Cell Signaling Technology,#12165 LDHA,Santa Cruz Biotechnology,sc-137243 LDHB,Santa Cruz Biotechnology,sc-100775 MFN2,Abcam,ab56889 Oxphos,Invitrogen,45-8099 PDHE1a,Santa Cruz Biotechnology

(9) Glycolysis Aids in Human Lens Epithelial Cells' Adaptation to HypoxiaAntioxidants (Basel, Switzerland)June 19, 2023Huang Y, Ping X, Cui Y, Yang H, Bao J, Yin Q, Ailifeire H, Shentu X.Proteintech, Rosemont, IL, USA), anti-HK1 (2024, Cell Signaling Technology (CST), Danvers, MA, USA), anti-HK2 (sc-374091, Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-PGK1 (sc-130335, Santa Cruz Biotechnology), anti-ENO2

(10) Metabolic regulation of the proteasome under hypoxia by Poldip2 controls fibrotic signaling in vascular smooth muscle cellsFree radical biology & medicineFebruary 1, 2023Paredes F, Williams HC, Suster I, Tejos M, Fuentealba R, Bogan B, Holden CM, San Martin A.,Santa Cruz,sc-14939 GFP,Rockland,600120215 O-GlcNAc,Cell Signaling,98755 O-GlcNAc,Abcam,ab2739 HK2,Santa Cruz,sc-374091 GFP2,Cell Signaling,98755 p-CDK2,Abcam,Ab183554 CDK2,Santa Cruz,sc-163 p-EZH2,Active Motif,61241 PSMC1,Bethyl Laboratories

(11) Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolismFluids and barriers of the CNSDecember 9, 2022Weber CM, Moiz B, Zic SM, Alpízar Vargas V, Li A, Clyne AM.Number GLUT1,Thermo Fisher,21829–1-AP HXK I,Santa Cruz Biotechnology,sc-46695 HXK II,Santa Cruz Biotechnology,sc-374091 GPI,Santa Cruz Biotechnology,sc-365066 PFKFB3,Cell Signaling Technology,13123S PFK1,Santa Cruz Biotechnology,sc-166722 AldoA,Santa Cruz Biotechnology

(12) Flow pattern-dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cellsJCI insightSeptember 22, 2022Hong SG, Shin J, Choi SY, Powers JC, Meister BM, Sayoc J, Son JS, Tierney R, Recchia FA, Brown MD, et al.(MilliporeSigma, MAB1398Z), PDK1 (Santa Cruz Biotechnology Inc., sc-515944), HK2 (Santa Cruz Biotechnology Inc., sc-374091), T-eNOS (BD Biosciences, 610296), OPA1 (BD Biosciences, 612606), Mfn2 (Santa Cruz Biotechnology Inc.,

(13) Hexokinase 2 promoted cell motility and proliferation by activating Akt1/p-Akt1 in human ovarian cancer cellsJournal of ovarian researchAugust 11, 2022Tian X, Liu D, Zuo X, Sun X, Wu M, Li X, Teng Y.

(14) Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer CellsPharmaceuticals (Basel, Switzerland)March 21, 2022Barrios-Bernal P, Hernandez-Pedro N, Orozco-Morales M, Viedma-Rodríguez R, Lucio-Lozada J, Avila-Moreno F, Cardona AF, Rosell R, Arrieta O.

(15) Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer PatientsGenesMarch 20, 2022Ishfaq M, Bashir N, Riaz SK, Manzoor S, Khan JS, Bibi Y, Sami R, Aljahani AH, Alharthy SA, Shahid R.

(16) Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2⁺ macrophage differentiationScience advancesFebruary 25, 2022Zhou WJ, Yang HL, Mei J, Chang KK, Lu H, Lai ZZ, Shi JW, Wang XH, Wu K, Zhang T, et al.#sc46695), HK II (1:100; Santa Cruz Biotechnology, #sc271459), GPI (1:100; Santa Cruz Biotechnology, #sc374091), PFK1 (1:100; Santa Cruz Biotechnology, #sc377346), FBP1 (1:100; Santa Cruz Biotechnology, #sc271241),

(17) Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancersCell reportsFebruary 1, 2022Shen J, Yang C, Zhang MS, Chin DW, Chan FF, Law CT, Wang G, Cheng CL, Chen M, Wan RT, et al.

(18) Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiationScientific reportsJanuary 7, 2022Sato T, Ichise N, Kobayashi T, Fusagawa H, Yamazaki H, Kudo T, Tohse N.(sc-135657, Santa Cruz, Dallas, TX), PHD2 (CST #3293, Cell Signaling), GLUT1 (ab115730, Abcam), HK2 (sc-374091, Santa Cruz), PFKM (ab154804, Abcam), and GAPDH (sc-25778, Santa Cruz) for the glycolytic pathway, G6PD

(19) Hexokinase 2 Promotes Cell Proliferation and Tumor Formation through the Wnt/β-catenin Pathway-mediated Cyclin D1/c-myc Upregulation in Epithelial Ovarian CancerJournal of CancerJanuary 1, 2022Liu X, Zuo X, Sun X, Tian X, Teng Y.≥ 2 was defined as strong positive. The antibodies used were as follows: anti-HK2 (1:200 dilution, sc-374091, Santa Cruz, USA), anti-Ki67 (1:200 dilution, sc-23900, Santa Cruz, USA), anti-Cyclin D1 (1:200 dilution,

(20) Hexokinases 2 promoted cell motility and distant metastasis by elevating fibronectin through Akt1/p-Akt1 in cervical cancer cellsCancer cell internationalNovember 10, 2021Chen Q, Li L, Liu X, Feng Q, Zhang Y, Zheng P, Cui N.Fisher Scientific (New York, NY, USA). The antibodies used were as follows: anti-HK2 (1:500 dilution, sc-374091, Santa Cruz, USA), anti-Akt1 (1:500 dilution, sc-5298, Santa Cruz, USA), anti-p-Akt1 (1:500 dilution,

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HXK II (B-8) Antibody

HXK II (B-8) Antibody from Santa Cruz Biotechnology, Inc.

Santa Cruz Biotechnology, Inc.

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HXK II (B-8) Antibody from Santa Cruz Biotechnology, Inc.

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