Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab Rabbit mAb mix 9607S from Cell Signaling Technology

Product Specs
ItemPhospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab Rabbit mAb mix
CompanyCell Signaling Technology
Price $431.00 Inquire
Catalog Number9607S
Quantity100 µl
ApplicationsW, IP
ReactivityAll
HostRabbit
ClonalityMonoclonal
ModificationsATM Substrate motif [L(s/t)Q] phosphate
Research AreaMotif Antibodies
IsotypeIgG
CloneD23H2

Questions and Answers

Can this antibody be used to study the phosphorylation of PTEN in response to DNA damage?

Yes, the Phospho-ATM/ATR Substrate (S*Q) antibody has been shown to detect phosphorylation of PTEN at S398 in vivo, particularly in studies involving genotoxic stress. This was demonstrated in research where the antibody was utilized to analyze HA immunoprecipitates from HEK293 cells treated with DNA-damaging agents ().

Is this antibody effective for detecting phosphorylation events in different species?

The Phospho-ATM/ATR Substrate (S*Q) antibody exhibits broad reactivity across various species, including human, mouse, zebrafish, and several other mammals and non-mammalian organisms. This makes it suitable for comparative studies in diverse biological contexts.

How has this antibody been utilized in the context of DNA damage response research?

The antibody has been employed in studies examining the cellular response to DNA double-strand breaks, particularly in the context of ATM signaling pathways. For instance, it has been used to validate phosphorylation sites in proteins involved in the DNA damage response, as seen in studies focusing on the modulation of phosphorylation levels following ionizing radiation exposure ().

What applications is this antibody suitable for in laboratory experiments?

The Phospho-ATM/ATR Substrate (S*Q) antibody is suitable for applications such as Western blotting and immunoprecipitation. It has been effectively used to analyze phosphorylation states of various substrates involved in the DNA damage response, providing insights into the signaling mechanisms activated during cellular stress.

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Website: Technical Support

(1) Sleep prevents brain phosphoproteome disruption to safeguard survivalCell DiscovJune 24, 2025Jing Ma, Juhang Liu, Yu Li, Yikui Zhao, Yu Tian, Bing Hu, Kaiyue Yan, Ying Li, Kaihang Ding, Xiangyu Wang, et al.substrate motif ((K/R)XS*X(K/R)) (#6967, Cell Signaling), anti-phospho-ATM/ATR substrate motif (S*Q) (#9607, Cell Signaling) and anti-HA (C29F4) (#3724, Cell Signaling), p-HDAC4 S246 (#ab240643, Abcam), p-KCC2

(2) Mec1-mediated Atg9 phosphorylation regulates the PAS recruitment of Atg9 vesicles upon energy stressProceedings of the National Academy of SciencesFebruary 11, 2025Siyu Fan, Shuling Dong, Weijing Yao, Yi Zhang, Mingzhu Fan, Shan Feng, Choufei Wu, Liqin Zhang, Cong Yi1:3,000), anti-MYC (Vazyme, RA1005; 1:3,000), anti-Phospho-ATM/ATR Substrate (Cell Signaling Technology, 9607S; 1:1,000), anti-thiophosphate ester (HUABIO, ET1612-11; 1:2,000), HRP* goat anti-mouse IgG(H+L) (Immunoway,

(3) Obesity-associated non-oxidative genotoxic stress alters trophoblast turnover in human first-trimester placentasMolecular Human ReproductionAugust 5, 2024Denise Hoch, Alejandro Majali-Martinez, Julia Bandres-Meriz, Martina Bachbauer, Caroline Pöchlauer, Theresa Kaudela, Ezgi Eyluel Bankoglu, Helga Stopper, Andreas Glasner, Sylvie Hauguel-De Mouzon, et al.(09-070)" p-ATM/ATR Substrates (S*Q),Rabbit,1:1000,"Cell Signaling Technology, Danvers, MA, USA (#9607)" P53,Mouse,1:500,"Santa Cruz Biotechnology, Dallas, TX, USA (sc-126)" pSer15-p53,Rabbit,1:1000,"Cell Signaling Technology

(4) DNA damage remodels the MITF interactome to increase melanoma genomic instabilityGenes & DevelopmentFebruary 13, 2024Romuald Binet, Jean-Philippe Lambert, Marketa Tomkova, Samuel Tischfield, Arianna Baggiolini, Sarah Picaud, Sovan Sarkar, Pakavarin Louphrasitthiphol, Diogo Dias, Suzanne Carreira, et al.phospho-S325,Custom-made, Phospho-ATM (Ser1981),Abcam,ab81292 Phospho-ATM/ATR substrate (S*Q),Cell Signaling Technology,9607 Phospho-Chk1 (Ser345),Cell Signaling Technology,2348 Phospho-Chk2 (Thr68),Cell Signaling Technology,2197 Phospho-H2AX

(5) Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expressionCell reportsSeptember 20, 2022Sugitani N, Vendetti FP, Cipriano AJ, Pandya P, Deppas JJ, Moiseeva TN, Schamus-Haynes S, Wang Y, Palmer D, Osmanbeyoglu HU, et al.,Cell Signaling Technologies,2325 Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab™,Cell Signaling Technologies,9607 S9.6,Millipore,MABE1095 PCNA,Abcam,ab92552 phospho-RNA polymerase II (S5),Abcam,ab5408 TruStain FcX PLUS (anti-mouse CD16/32

(6) Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaksiScienceSeptember 16, 2022Gräf JF, Mikicic I, Ping X, Scalera C, Mayr K, Stelzl LS, Beli P, Wagner SA.RRID:AB_2779000 GFP,Chromotek,PABG1; RRID:AB_2749857 Phospho-ATM/ATR substrate Motif (pSQ),Cell Signaling,9607; RRID:AB_10889739 Polyclonal Goat Anti-Mouse Immunoglobulins/HRP,Agilent Technologies,P044701-2; RRID:AB_2617137 Polyclonal

(7) And-1 Coordinates with the FANCM Complex to Regulate Fanconi Anemia Signaling and Cisplatin ResistanceCancer researchSeptember 16, 2022Zhang Y, Li J, Zhou Y, Li Z, Peng C, Pei H, Zhu W.(ab104236) were from Abcam; antibodies against FANCA (#14657), FANCB (#14243), phospho-ATR/ATM substrate (#9607) were from Cell Signaling; antibodies against cisplatin-DNA adduct (#MABE416) were from Millipore We

(8) Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1Genome Instab DisJanuary 1, 2022Qin B, Yu J, Zhao F, Huang J, Zhou Q, Lou Z.western), anti-Mre11 (4847, 1:1000 for western), anti-Rad50 (3427, 1:1000 for western), anti-SQ/TQ motif (9607, 1:1000 for western), anti-Chk2 (2662, 1:1000 for western), and anti-phosphoChk2 (2197, 1:1000 for western)

(9) Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in DrosophilaFrontiers in Cell and Developmental BiologyApril 14, 2021Lisa Frankenreiter, Bernd M. Gahr, Hannes Schmid, Mirjam Zimmermann, Sebastian Deichsel, Philipp Hoffmeister, Aleksandra Turkiewicz, Tilman Borggrefe, Franz Oswald, Anja C. NagelSepharose beads (Roche) were pre-incubated with 10 μl of phospho-ATM/ATR substrate (S∗Q) mAB (CST #9607) at 4°C overnight, mixed with protein extracts and immuno-complexes allowed to form for 2 h at 4°C.

(10) DOCK7 protects against replication stress by promoting RPA stability on chromatinNucleic acids researchApril 6, 2021Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, et al.anti-ATR (2790, 1:1000), anti-Myc Tag (2276, 1:2000), anti-histone H3 (4499, 1:2000) and anti-SQ/TQ motif (9607, 1:1000) were purchased from CST; anti-GAPDH (60004–1-lg, 1:2000), anti-Cdc42 (10155–1-AP, 1:2000),

(11) Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replicationPLOS PathogensJanuary 25, 2021Ji Xi, Laura Luckenbaugh, Jianming HupS-Q motif, Phospho-ATM/ATR Substrate Motif (S*Q), was purchased from Cell Signaling Technology (CST #9607). The rabbit anti-HBs polyclonal antibody was purchased from Virostat. Transient transfection HepG2 cells

(12) The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylationNature communicationsJanuary 4, 2021Fan G, Sun L, Meng L, Hu C, Wang X, Shi Z, Hu C, Han Y, Yang Q, Cao L, et al.(1:2000, HPA055997, Sigma-Aldrich; 1:500, ab172620, Abcam), phospho-ATM/ATR substrate (S/TQ) (1:500, #9607; Cell Signaling Technology, Danvers, MA, USA), ATM (1:500, ab32420; Abcam, Cambridge, UK), ATR (1:500,

(13) Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degenerationAgingNovember 4, 2020Zhang W, Cheng W, Parlato R, Guo X, Cui X, Dai C, Xu L, Zhu J, Zhu M, Luo K, et al.(Cambridge, UK). Antibodies for phospho-p53 (Ser15) (#9284), phospho-ATM/ATR substrates (S/T*Q motif) (#9607), and MMP-2 (#40994) were from Cell Signaling (Beverley, MA, USA). Anti-MMP-9 was from R&D Systems (AF909)

(14) Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegansPLoS geneticsNovember 1, 2020Sato-Carlton A, Nakamura-Tabuchi C, Li X, Boog H, Lehmer MK, Rosenberg SC, Barroso C, Martinez-Perez E, Corbett KD, Carlton PM.LTQ-Orbitrap-Elite ESI-CID (Thermo Fisher). Phosphoenrichment antibodies were obtained from CST (catalog numbers 9607, 6966, 8139, 8738, 9624, 6967, 5759, 9942, 10001, 9614, 9477, 8134, 2325, 5243, and 3004). Protein assignments

(15) USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIPNature communicationsOctober 23, 2020Gao M, Guo G, Huang J, Kloeber JA, Zhao F, Deng M, Tu X, Kim W, Zhou Q, Zhang C, et al.purchased from Sigma; anti-pS345 Chk1 (2348, 1:1000), anti-Myc Tag (2276, 1:2000) and anti-SQ/TQ motif (9607, 1:1000) were purchased from CST; anti-CtIP (61141, 1:1000 for IF) was purchased from Active Motif;

(16) Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activationNucleic Acids ResearchSeptember 18, 2020Katheryn MeekCell signaling, 3488), rabbit anti-phospho-S/T-Q (working concentration, 1:1000; Cell signaling, 2851 and 9607). The DNA-PKcs antibody (working concentration, 1:1000; 42-27) was the generous gift of Tim Carter.

(17) STK38 promotes ATM activation by acting as a reader of histone H4 ufmylationScience advancesJune 1, 2020Qin B, Yu J, Nowsheen S, Zhao F, Wang L, Lou Z.from Sigma-Aldrich. Anti-ATM (2873), anti-pSer1981 ATM (13050), anti-SUV39H1 (8729), anti-SQ/TQ motif (9607, 1:1000 for Western blot), anti-Chk2 (2662), and anti-phosphoChk2 (2197) antibodies were purchased from

(18) Deciphering MET-dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomicsMolecular oncologyJune 1, 2020Bensimon A, Koch JP, Francica P, Roth SM, Riedo R, Glück AA, Orlando E, Blaukat A, Aebersold DM, Zimmer Y, et al.Antibodies MET Tyr1234&1235 (#3077), NUMA1 Ser395 (#3429), phospho‐Ser/Thr‐Gln‐Gly (#6966), phospho‐Ser‐Gln (#9607), phospho‐Thr(Asp/Glu)X(Asp/Glu) (#BL4176), phospho‐Thr‐X‐Arg (#2351), CHEK1 Ser345 (#2341), CHEK1 (2G1D5;

(19) Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stabilityThe Journal of cell biologyDecember 2, 2019Achuthankutty D, Thakur RS, Haahr P, Hoffmann S, Drainas AP, Bizard AH, Weischenfeldt J, Hickson ID, Mailand N.Europe), phospho-(Ser) CDK substrate (pSP; 2324; Cell Signaling), and phospho-ATM/ATR substrate (pSQ; 9607; Cell Signaling). Polyclonal phospho-specific antibodies to S95 and S111 in human ETAA1 were produced

(20) Targeting Angiogenesis by Blocking the ATM-SerRS-VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma GrowthCancersNovember 22, 2019Song Y, Lu H, Wang Q, Xiang R.11, 1847 14 of 19 Anti-P-ATM (4526), anti-ATM (2873), and anti-phosphor-ATM/ATR Substrate (S*Q) (9607) were from Cell Signaling Technology (Beverly, MA, USA). For ELISA, VEGFA kits (ab119566, ab119565)

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Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab ™ Rabbit mAb mix

Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab Rabbit mAb mix from Cell Signaling Technology

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Questions and Answers

Cell Signaling Technology

Citations (34)

Reviews

Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) MultiMab Rabbit mAb mix from Cell Signaling Technology

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