HDAC6 (D21B10) Rabbit mAb 7612S from Cell Signaling Technology

Product Specs
ItemHDAC6 (D21B10) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number7612S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M, R
TargetHDAC6
HostRabbit
NCBI Gene AliasesCPBHM, HD6, JM21, PPP1R90
ClonalityMonoclonal
NCBI Full Gene Namehistone deacetylase 6
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD21B10
Molecular Weight160

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathologyCell ReportsMarch 24, 2026Neha Mohan, Skandha Ramakrishnan, Xiaohuan Sun, Ying Sun, Theresa Connors, Victor Chai, Emanuela Piermarini, Peter W. Baas, James Cai, Mei Liu, et al.RRID:AB_2564642 Acetylated Tubulin,Sigma-Aldrich,Cat# T6793; RRID:AB_477585 HDAC6,Cell Signaling Technology,Cat# 7612; RRID:AB_10889735 βIII- Tubulin,Abcam,Cat# ab7751; RRID:AB_306045 GAPDH,Abcam,Cat# ab8245; RRID:AB_2107448 Spastin,Abcam,Cat#

(2) Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug bindingJ Biol ChemJuly 25, 2025Jennifer A. Heritz, Katherine A. Meluni, Sarah J. Backe, Sara J. Cayaban, Laura A. Wengert, Meik Kunz, Mark R. Woodford, Dimitra Bourboulia, Mehdi Mollapourprocedures Reagents and chemicals Antibodies Antibodies for HDAC1-8 (5356, 5113, 85057, 7628, 20458, 7612, 33418) and HDAC11 (66042), GAPDH (97166), and all secondary antibodies raised in mouse (7076), rabbit

(3) Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK-3β SignalingFASEB JMay 31, 2025Shangzhi Shu, Junqiao Fang, Longguo Zhao, Jiatong Han, Meiping Zhang, Chaoqun Huang, Xian Wu Cheng, Shuyan LiMedChemExpress, Monmouth Junction, NJ) were incubated with 1–2 μg of antibody (rabbit anti‐HDAC6, Cat.no. 7612, CST; rabbit anti‐GSK3β, Cat.no. 9315, CST; rabbit anti‐TFAM, Cat.no. 22586‐1‐AP, Proteintech) or IgG Isotype control antibody

(4) CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6Cell Death DisApril 20, 2025Giorgia Iegiani, Gianmarco Pallavicini, Alex Pezzotta, Alessia Brix, Alessia Ferraro, Marta Gai, Enrica Boda, Stephanie L. Bielas, Anna Pistocchi, Ferdinando Di Cuntoanti-γ-H2AX (S139; 20E3; #2577; Cell Signaling Technology, Danvers, DA, USA), rabbit polyclonal anti-HDAC6 (#7612S; Cell Signaling Technology), rabbit polyclonal anti-RPA32 (#ab87277; Abcam), mouse monoclonal anti-Lamin A

(5) Mechanistic Advances in the Therapeutic Application of Bixin for Lung Inflammation In Vitro and In VivoPharmaceuticals (Basel)April 5, 2025Alexsandro Tavares Figueiredo-Junior, Bruno Clemente Brandão Marques, Douglas Galdino Dos dos Santos, Wesley Leandro Gouveia, Raysa Magali Pillpe Meza, Luzineide Wanderley Tinoco, Lídia Moreira Lima, Samuel Santos Valenca, Manuella LanzettiUSA), anti-NOS2 (ab178945-rabbit-1:1000; gel of 8%) (Abcam—Cambridge, United Kingdom), anti-HDAC6 (#7612-rabbit-1:1000; gel of 8%) (Cell Signaling Technology—Danvers, MA, USA), and anti-β-actin (a5441-mouse-1:5000;

(6) The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary ResuscitationMediators InflammMarch 20, 2025Chenyu Zhang, Hongyan Wei, Qiang Zhang, Haohong Zhan, Yuanzheng Lu, Yujie Li, Bo Li, Wen Huang, Feng Nian, Rong Liu, et al.Bax (14796), histone H3 (9715S), HDAC1 (34589), HDAC2 (57156), HDAC3 (85057), HDAC4 (7628), HDAC6 (7612) from CST (Cell Signaling Technology, Danvers, MA, USA), and HDAC7 (ab12174), HDAC8 (ab187139), HDAC9

(7) IL-27 alleviates high-fat diet-induced obesity and metabolic disorders by inhibiting adipogenesis via activating HDAC6Commun BiolMarch 19, 2025Yinsheng Zhong, Shujun Yang, Shuangmei Li, Sijun Yuan, Xuxiang Chen, Huibao Long, Haidong Wu, Yajie Guo, Tong Wang(Cell Signaling Technology, 8178), FABP4 (Cell Signaling Technology, 2120), HDAC6 (Cell Signaling Technology, 7612), p-Akt (Cell Signaling Technology, 4060), Akt (Cell Signaling Technology, 4691), β-catenin (Cell Signaling Technology

(8) Histone deacetylase 6 inhibition prevents hypercholesterolemia-induced erectile dysfunction independent of changes in markers of autophagySex MedJanuary 9, 2025Colin M Ihrig, McLane M Montgomery, Yohei Nomura, Mitsunori Nakano, Deepesh Pandey, Justin D La Favordismutase 2 (SOD2, CST #13141, 1:1000), BCL2 interacting protein 3 (BNIP3, CST #3769, 1:1000), HDAC6 (CST #7612, 1:1000), autophagy-related protein 5 (ATG5, CST #12994, 1:1000), autophagy-related protein (ATG7, CST

(9) HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responsesEMBO ReportsJanuary 2, 2025Qiongzhen Zeng, Zixin Chen, Shan Li, Ziwei Huang, Zhe Ren, Cuifang Ye, Xiao Wang, Jun Zhou, Kaisheng Liu, Kai Zheng, et al.K110T,This study,N/A Antibodies,Antibodies,Antibodies "Anti-HDAC6 (WB, IP)",Cell Signaling Technology,7612 Anti-α-tubulin,Cell Signaling Technology,3873 Anti-acetyl-α-tubulin,Cell Signaling Technology,5335 Anti-cGAS,Cell Signaling Technology

(10) Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channelsJournal of Biological ChemistryJanuary 1, 2025Fang Wang, Baoqiang Wang, Xiwei Gu, Xiaoxu Li, Xinyu Liu, Baoxin LiSanta Cruz Biotechnology, sc-377388, RRID: AB_3107179), HDAC6 (1:1000 dilution, Cell Signaling Technology, catalog no.: 7612, RRID: AB_10889735), β-actin (1:1000 dilution, ABclonal, catalog no.: AC004, RRID: AB_2737399), Ub (1:200

(11) Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer diseaseAutophagyDecember 24, 2024Qian Liu, Xin Wang, Zhi-Ting Fang, Jun-Ning Zhao, Xue-Xiang Rui, Bing-Ge Zhang, Ye He, Rui-Juan Liu, Jian Chen, Gao-Shang Chai, et al.1:500 Anti-GRIA2/GluA2,"Sigma-Aldrich, AB1768–1",WB: 1:500 Anti-HDAC6,"Cell Signaling Technology, 7612",WB: 1:500 Anti-acetyl-TUBA/alpha tubulin,"Abclonal Technology, A24738",WB: 1:500 Anti-CTTN/cortactin,"Abcam,

(12) Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathwaysJournal of Molecular MedicineDecember 19, 2024Pengtao Wang, Wei Tao, Qiujie Li, Wanting Ma, Wei Jia, Yuting Kang,Affinity Biosciences",1:200,1:500 Phospho-NF-kB p65,"AF2006,Affinity Biosciences",,1:500 HDAC5,"sc-133225,Santacruz",,1:1000 HDAC6,"7612S,CST",,1:500 NLRP3,"15101S,CST",,1:500 ASC,"67824S,CST",,1:500 Caspase-1,"89332S,CST",,1:500 IL-1β,"63124S,CST",,1:500 GAPDH,"60004–1-Ig,Proteintech",,1:2000 "Anti-mouse

(13) Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid TumorsJournal of medicinal chemistryAugust 22, 2024Zhao C, Zhang J, Zhou H, Setroikromo R, Poelarends GJ, Dekker FJ.Cell Signaling, #3949), anti-HDAC4 (1:2000 Cell Signaling, #7628), anti-HDAC6 (1:1000, Cell Signaling, #7612), anti-HDAC7 (1:1000 Cell Signaling, #33418), anti-HDAC8 (1:1000 Cell Signaling, #66042), anti-HDAC11

(14) Dynamic Alterations in Acetylation and Modulation of Histone Deacetylase Expression Evident in the Dentine–Pulp Complex during DentinogenesisInternational Journal of Molecular SciencesJune 14, 2024Yukako Yamauchi, Emi Shimizu, Henry F. Duncanincubation at 4 °C with primary antibodies raised against HDAC-1, -2, -3, -4 (#9928), -5 (#20458), and -6 (#7612, All Cell Signaling Technology, Leiden, The Netherlands) and β-actin (#3700, Cell Signaling Technology,

(15) Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptationDevelopmental CellJune 1, 2024Yusheng Shen, Kassandra M. Ori-McKenneyab31704, RRID:AB_873537" "Anti-HDAC6, rabbit monoclonal recombinant, D21B10",Cell Signaling,"Cat# 7612, RRID:AB_10889735" "Anti-αTAT1, rabbit polyclonal",Atlas Antibodies,"Cat# HPA046816, RRID:AB_2679822" "Anti-GFP,

(16) HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversingRespiratory ResearchFebruary 5, 2024Qin Zhang, Liming Yan, Ye Lu, Xiaodong Liu, Yan Yin, Qiuyue Wang, Xiu Gu, Xiaoming Zhouprimary antibodies were as follows: HDAC6 rabbit monoclonal antibody (1:1000; Cell Signaling Technology, 7612), ZO-1 rabbit monoclonal antibody (1:1000; Cell Signaling Technology, 13,663), Occludin rabbit monoclonal

(17) Chronic hypoxia stabilizes 3βHSD1 via autophagy suppressionCell reportsJanuary 23, 2024Qin L, Berk M, Chung YM, Cui D, Zhu Z, Chakraborty AA, Sharifi N.monoclonal anti-HDAC5,Cell Signaling,20458;RRID:AB_2713973 Rabbit monoclonal anti-HDAC6,Cell Signaling,7612;RRID:AB_10889735 Rabbit monoclonal anti-HDAC7,Cell Signaling,33418;RRID:AB_2716756 Rabbit monoclonal

(18) TRIM25 targets p300 for degradationLife Science AllianceDecember 1, 2023Seham Elabd, Eleonora Pauletto, Valeria Solozobova, Nils Eickhoff, Nuno Padrao, Wilbert Zwart, Christine Blattnerreceptor antibody [441, sc-7305]). Other antibodies (anti-LC3 [D3U4C, #12741P], anti-HDAC6 [D21B10, #7612S], anti-p300 [D8Z4E, #86377], anti-ISG15 [#2743S]) were from Cell Signaling. The anti-p300 antibody for

(19) An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarctionScience advancesApril 5, 2023Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T, Zhu H, Liu Y, et al.Active Motif), HDAC3 (1:1000; 85057S, Cell Signaling Technology), HDAC5 (1:1000; ab55403, Abcam), HDAC6 (1:500; 7612S, Cell Signaling Technology), HDAC9 (1:500; ab59718, Abcam), p-STAT3 (1:1000; 9145S, Cell Signaling Technology),

(20) ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbanceiScienceJanuary 20, 2023Kuo TL, Cheng KH, Chen LT, Hung WC.RRID:AB_10547753 HDAC5,Cell Signaling Technology,Cat# 2082; RRID:AB_2116626 HDAC6,Cell Signaling Technology,Cat# 7612; RRID:AB_10889735 Acetyl-Histone H3,Cell Signaling Technology,Cat# 7627; RRID:AB_10839410 Neurogenin-3,Abnova,Cat#

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HDAC6 (D21B10) Rabbit mAb

HDAC6 (D21B10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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HDAC6 (D21B10) Rabbit mAb from Cell Signaling Technology

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