Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb 8174S from Cell Signaling Technology

Product Specs
ItemPhospho-FoxO3a (Ser413) (D77C9) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number8174S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetFoxO3a (Ser413) phosphate
IsotypeIgG
ModificationsFoxO3a (Ser413) phosphate
HostRabbit
CloneD77C9
Molecular Weight82-97
NCBI Gene AliasesAF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
ClonalityMonoclonal
NCBI Full Gene Nameforkhead box O3
Research AreaPI3K / Akt Signaling

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Erk3 deletion drives oxidative adaptations in skeletal muscleMolecular MetabolismFebruary 24, 2026Angel Loza-Valdes, Carlos Acosta-Gallo, Toufic Kassouf, Andrei Belykh, Małgorzata Stelmach, Dominika Malińska, Katia El Ghoz, Rabih El-Merahbi, Filip Dziaczkowski, Katarzyna Kolczyńska-Matysiak, et al.(Thr24) (Cell Signaling, 94645), α-FOXO3a (Cell Signaling, 2497s), α-p-FOXO3a (Ser413) (Cell Signaling, 8174S), α-GAPDH (Sigma, G9545), α-MYHC (Bio-Techne, MAB4470), α-desmin (Cell Signaling, 5332T), α-vinculin

(2) Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathwayScience advancesNovember 21, 2025Hara Y, Lemgart VT, Lessard S, Mercadante CJ, Ribeil JA, Hicks A, Rimmele P, Light DR.anti-FOXO3 (Cell Signaling Technology, #2497), anti–phospho-FOXO3-Ser413 (Cell Signaling Technology, #8174), anti-SQSTM1 (Cell Signaling Technology, #88588), anti–phospho-SQSTM1-Ser403 (Cell Signaling Technology,

(3) A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expressionExp Hematol OncolMarch 28, 2025Xiuqin Bao, Yuanyi Gao, Xiaoyi Chen, Zhongju Wang, Xiaoqin Feng, Liren Wang, Jing Du, Yuhua Ye, Feijing Chen, Li Du, et al.antibody), anti-lamin A/C (ab238303, Abcam), anti-β-Tublin (ab6046, Abcam); anti-phospho-FOXO3 (Ser413) (8174s), anti-phospho-AMPK (Thr172) (2535T), all from Cell Signaling Technology. HPLC HbF and HbA levels

(4) ECM stiffness regulates lung fibroblast survival through RasGRF1 dependent signalingJournal of Biological ChemistryJanuary 8, 2025Elizabeth Monaghan-Benson, Julien Aureille, Christophe Guilluyphospho-Bim S69 (4584, Cell Signaling Technology), FOXO3a (2497, Cell Signaling Technology), phospho-FOXO3a (8174, Cell Signaling Technology), Sos (12409, Cell Signaling Technology), GAPDH (5174, Cell Signaling Technology)

(5) Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulationAutophagyMay 3, 2024Karolina Pierzynowska, Magdalena Podlacha, Lidia Gaffke, Estera Rintz, Karolina Wiśniewska, Zuzanna Cyske, Grzegorz Węgrzyn99,199), and monoclonal anti-phosphorylated FOXO3 for western blotting (Cell Signaling Technology, 8174). The anti-mouse and anti-rabbit antibodies, as well as anti-GAPDH antibodies, were from Sigma Aldrich

(6) AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient StarvationInternational journal of molecular sciencesAugust 15, 2023Urushihara Y, Hashimoto T, Fujishima Y, Hosoi Y.phospho-EGFR (Tyr845) antibody (#2231, CST); FOXO3a antibody (#12829, CST); phospho-FOXO3a (Ser413) antibody (#8174, CST); hypoxia-inducible factor-1 alpha (HIF-1α) antibody (#A300-286A, Bethyl Laboratories, Inc., Montgomery,

(7) Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosisRedox biologyJuly 1, 2023Zhong S, Chen W, Wang B, Gao C, Liu X, Song Y, Qi H, Liu H, Wu T, Wang R, et al.FoxO3a (1:1000,proteintech,#66428-1-Ig), rabbit p-FoxO3a(Ser413)(1:1000,Cell Signaling technology,#8174), rabbit CYCs (1:1000,Cell Signaling technology,#11940S), rabbit HMOX1 (1:1000,ABclonal,#A19062), rabbit

(8) Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammationiScienceDecember 17, 2021Suarez-Lopez L, Shui B, Brubaker DK, Hill M, Bergendorf A, Changelian PS, Laguna A, Starchenko A, Lauffenburger DA, Haigis KM.12155, 1:2000), anti-phospho-Hsp27 (CST 9709, 1:2000) anti-Hsp27 (CST 2442, 1:2000) anti-GAPDH (CST 8174 1:2000). Fluorescently labelled secondary antibodies were used for protein detection in Odyssey fluorescence imaging

(9) Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of PharmacologyNovember 1, 2021Bae JH, Seo DY, Lee SH, Shin C, Jamrasi P, Han J, Song W.and p62 (126M4796V) from Sigma-Aldrich; BNIP3 (#3769), Beclin 1 (#3738), FOXO3a (#2497), p-FOXO3a (#8174), AKT (#4691), p-AKT (#9271), mTOR (#2972), p-mTOR (#5536), 4EBP1 (#9644), and p-4EBP1 (#9459) from

(10) Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagyNature communicationsDecember 8, 2020Yu YS, Shin HR, Kim D, Baek SA, Choi SA, Ahn H, Shamim A, Kim J, Kim IS, Kim KK, et al.(Rme2a) (#13522), anti-CARM1 (#3379), anti-LC3 (#2775), anti-FOXO3a (#2497), anti-phospho-FOXO3a S413 (#8174), and anti-Tip60 (#12058) (Cell Signaling Technology); anti-FOXO3a (ab12162) and anti-H3R17me2 (ab8284)

(11) Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunitsThe EMBO journalJuly 1, 2020Kruse T, Gnosa SP, Nasa I, Garvanska DH, Hein JB, Nguyen H, Samsøe-Petersen J, Lopez-Mendez B, Hertz EPT, Schwarz J, et al.scaffold subunit (#2041, 1:1,000, Cell Signaling Technology) GFP (ab290, 1:4,000, Abcam), FoxO3 pS413 (#8174, 1:1,000, Cell Signaling Technology), FoxO3 rabbit polyclonal α‐pS253 (Raised against peptide CAPRRRAV(pS)MDNS;

(12) Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubesAmerican Journal of Physiology-Cell PhysiologyDecember 1, 2019Blas A. Guigni, Dennis K. Fix, Joseph J. Bivona, Bradley M. Palmer, James A. Carson, Michael J. TothRRID:AB_915783), phospho-forkhead box O3a (phospho-FoxO3a; S413, 1:1,000, Cell Signaling Technology 8174, RRID:AB_10889562), phospho-FoxO3a (S253, 1:1,000, Cell Signaling Technology no. 9466, RRID:AB_2106674),

(13) Stress-induced modulation of volume-regulated anions channels in human alveolar carcinoma cellsPhysiological ReportsOctober 14, 2018Martin D. Bach, Belinda H. Sørensen, Ian H. Lambertmouse monoclonal Ab, 95 kDa, Sigma‐Aldrich; 1:250); Anti‐FoxO3a // Anti‐Phospho‐FoxO3 (Ser413) (2497//8174, rabbit Ab, 82‐97 kDa, Cell Signaling; 1:250//1:250); Anti‐GAPDH (ZG003, mouse monoclonal Ab, 37 kDa,

(14) A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cellsOncotargetAugust 3, 2018Senga S, Kawaguchi K, Kobayashi N, Ando A, Fujii H.Rabbit anti-p-AMPKα (T172)(Cat# 2535), Rabbit anti-FOXO3A (Cat# 2497S), Rabbit anti-p-FOXO3A (S413)(Cat# 8174S), Rabbit anti-p27 (Cat# 3686S), Rabbit anti-Puma (Cat# 12450), Rabbit anti-ERRα (Cat# 13826), Rabbit

(15) Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1OncogeneMarch 1, 2018Tanaka N, Zhao M, Tang L, Patel AA, Xi Q, Van HT, Takahashi H, Osman AA, Zhang J, Wang J, et al.for immunoblotting were: FOXM1 (Cell Signaling, Beverly, MA, USA; 5436), phospho-FOXO3a S413 (Cell Signaling; 8174), FOXO3a (Cell Signaling; 12829), phospho-AMPKα1 T172 (Cell Signaling; 2535), AMPKα1 (Cell Signaling;

(16) Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose TransportMolecular cellAugust 17, 2017Nagarajan A, Dogra SK, Sun L, Gandotra N, Ho T, Cai G, Cline G, Kumar P, Cowles RA, Wajapeyee N.,Santa Cruz Biotechnology,Cat#sc-374158 FOXO3A,Cell Signaling,Cat#2497 β-actin,Cell signaling,Cat#4970 Phospho-FOXO3A,Cell Signaling,Cat#8174 Phospho-AMPK,Cell Signaling,Cat#2535 AMPK,Cell Signaling,Cat#2532 PARP,Cell Signaling,Cat#9542 PUMA,Cell Signaling

(17) AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagyNatureJune 23, 2016Shin HJ, Kim H, Oh S, Lee JG, Kee M, Ko HJ, Kweon MN, Won KJ, Baek SH.immunoprecipitation and ChIP), anti-LC3 (2775), anti-phospho-AMPKαT172 (2535), anti-phospho-FOXO3a S413 (8174), anti-SQSTM1/p62 (5114), and anti-TFE3 (14779) antibodies were from Cell Signaling Technology. Anti-SKP2

(18) Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteomeBMC Systems BiologyDecember 1, 2015Traci L Marin, Brendan Gongol, Marcy Martin, Stephanie J King, Lemar Smith, David A Johnson, Shankar Subramaniam, Shu Chien, John Y-J Shyyab86607, and ab47476 respectively, P-FOXO3a and P-ATF2 primary antibodies from Cell Signaling (Cat # 8174 and 9221), and secondary antibodies (Cat# 7074S and 7076S). The blotted proteins bands were made detectable

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Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb

Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (18)

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Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb from Cell Signaling Technology

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