Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb 8592S from Cell Signaling Technology

Product Specs
ItemCleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $431.00 Inquire
Catalog Number8592S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityM
TargetCasp8 (Asp387) cleaved mouse
HostRabbit
NCBI Gene AliasesCASP-8, FLICE, MACH, Mch5
ClonalityMonoclonal
NCBI Full Gene Namecaspase 8
Research AreaApoptosis
IsotypeIgG
CloneD5B2
Molecular Weight18, 43

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Discovery of N8: a novel IKKε inhibitor with potent anticancer activity via cytotoxicity, migration suppression, and autophagy modulationJournal of Enzyme Inhibition and Medicinal ChemistryDecember 31, 2026Wei Ye, Siying Zheng, Hongmei Xie, Xinrui Zhou, Jiapeng Xu, Qiting Luo, Yuanyuan Huang, Jieyu Li, Jiayi Diao, Xinyi Luo, et al.proteins were used: LC3B (3868S, CST), p62 (PM045, MBL), caspase-3 (9662S, CST), cleaved-caspase-8 (8592 T, CST). Annexin V-FITC/PI apoptosis detection assay HCT116 cells were seeded in 6-well plates at

(2) Knockout of IGFBP3 improves alcohol-induced liver injury via Akt/GSK3β and TMEM219/caspase 8 pathwaysFront PhysiolMay 15, 2026Huimei Cai, Chenyu Zhu, Xi Zheng, Yiqi Lian, Enqi Tang, Yushan Chen, Wenyu Cao, Ying Sun, Yi Lvanti-p-Akt473 (#4060), anti-Akt (#4691), anti-p-GSK-3β (#5558), anti-GSK-3β (#12456), anti-Caspase 8 (#8592), and anti-GAPDH (#97166) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA);

(3) NDRG3 is essential for sustaining antigen-driven T cell responses by protecting against restimulation-induced cell deathJ ImmunolMay 14, 2026Brian J Stack, Susan M Kaechantibodies Target,Catalog number,Provider,Dilution CASP8,4927S,Cell Signaling Technology,"1,000" Cleaved CASP8,8592S,Cell Signaling Technology,"1,000" CASP3,9662S,Cell Signaling Technology,"1,000" Cleaved CASP3,9661S,Cell Signaling Technology

(4) Cytokine-driven PANoptosis of alveolar macrophages mediated by STAT1 underlies acute lung injury in hypervirulent Klebsiella pneumoniae infectionmBioMay 13, 2026Qi Xu, Xiaoxuan Liu, Heng Heng, Han Wang, Wenxing Zhao, Mei Luo, Guan Yang, Mingxiu Peng, Edward Wai-Chi Chan, Sheng Chen#14220), anti-cleaved-caspase-3 (CST, #9664), anti-caspase-8 (CST, #4927), anti-cleaved-caspase-8 (CST, #8592), anti-caspase-7 (CST, #9492T), anti-cleaved-caspase-7 (CST, #9661T), anti-RIP3 (CST, #3493), anti-phospho-RIP3

(5) Host response to bacteria induces a shift towards the enteroendocrine cell lineage in the murine enteroid modelPLOS PathogensMarch 23, 2026Marry Nissan, Adrienne Ranger, Justin J. Meade, Victoria Gillmore, Maija E. Lehn, Liliane Cabral-Fernandes, Derek K. L. Tsang, Scott D. Gray-Owen, Dana J. Philpott, Stephen E. GirardinCaspase 3 (Cell Signaling Technology,9661S, 1:1000), Cleaved Caspase 8 (Cell Signaling Technology, 8592, 1:1000), GAPDH (Cell Signaling Technology, 5174S, 1:10,000) and Goat anti-Rabbit IgG (H + L) Secondary

(6) Vinorelbine enhances the efficacy of oncolytic vaccinia virus in a preclinical model of ovarian high-grade serous carcinomaMolecular Therapy OncologyMarch 19, 2026Stephanie Drymiotou, Christophe J. Queval, Katherine E. Tyson, Lesley A. Sheach, Antonio Postigo, Ilaria Dalla Rosa, Darren P. Ennis, Michael Howell, Iain A. McNeish, Michael Way(1:1,000, Cell Signaling, Danvers, Massachusetts, #9542), cleaved caspase-8 (1:1,000, Cell Signaling, #8592), cleaved caspase-3 (1:1,000, Cell Signaling, #9664), LC3-B (1:1,000, Abcam [#ab48394], Cambridge, UK),

(7) Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infectionNature ImmunologyMarch 4, 2026Weixiang Liu, Jieming Ping, Lishan Deng, Ke Wang, Jinnuo Xu, Ningxin Peng, Mengyun Yang, Hesen Tang, Zhengjie Liu, Wenliang Wang, et al.obtained from R&D systems. Antibodies against caspase-3 (9662), caspase-7 (D6H1, 8438), caspase-8 (D5B2, 8592), caspase-9 (9504), phospho-ERKT202/Y204 (4370) and phospho-PKC (βII Ser660, 9371) were from Cell Signaling Technologies

(8) NLK facilitates Caspase-8 activation to drive macrophage PANoptosis in sepsisClin Transl MedFebruary 11, 2026Yun Xia, Ren-Qi Yao, Hui-Fan Liu, Guo-Qing Jing, Delida Aidebaike, Jing Zuo, Shi-Qi Wan, Die Wu, Peng-Yue Zhao, Hai-Long Gong, et al.outcomes. 2 MATERIALS AND METHODS 2.1 Reagents Primary antibodies against NLK (#94350), Caspase‐8 (#8592), Caspase‐3 (#96662), Caspase‐7 (#9492), MLKL (#37705), p‐MLKL (#37333), RIPK3 (#95702), p‐RIPK3 (#91702S),

(9) Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalkFrontiers in PharmacologyJanuary 26, 2026Yue Tu, Wenjie Liu, Tianqing Sang, Liuyunxin Pan, Wei Wu, Qijun Fang, Yinglu Liu, Buhui Liu, Yigang Wan#3493), anti-RIPK3 (1:1000, #15828), anti-caspase-8 (1:1000, #4790) and anti-cleaved-caspase-8 (1:1000, #8592) antibodies, respectively (Cell Signaling, Beverly, MA, United States). The levels of klotho and the

(10) The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver diseasebioRxivJanuary 17, 2026Qiang Qin, Wen Chen, Clay D. King, Sivakumar Prasanth Kumar, Peter Vogel, Rebecca E. Tweedell, Thirumala-Devi Kannegantianti-GSDME (Abcam, ab215191, 1:1,000), anti-caspase-8 (CST, 4927, 1:1,000), anti-cleaved caspase-8 (CST, 8592, 1:1,000), anti-caspase-3 (CST, 9662, 1:1,000), anti-cleaved caspase-3 (CST, 9661, 1:1,000), anti-caspase-7

(11) Innate detection of Salmonella replication triggers caspase-8-dependent apoptosis via TLR-driven TNF signaling and NLRC4-mediated sensing of the SPI-2 Type III secretion systembioRxivJanuary 16, 2026Beatrice I. Herrmann, Maxime Zamba-Campero, Reyna Garcia-Sillas, Winslow W. Yost, Lance W. Peterson, Justin L. Roncaioili, Shelley C. Rankin, Dieter M. Schifferli, Kodi Ravichandran, Igor E. Brodskythe figure legend. Primary antibodies specific for cleaved caspase-8 (Asp387/D5B2)(Cell Signaling: 8592S), cleaved caspase-3 (Asp175) (Cell Signaling: 9661S), caspase-8 (Enzo Life sciences: clone IG12 ALX 804–447-C100

(12) Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1J Exp MedJanuary 5, 2026Ran Liu, Gengqiao Wang, Zhengting Jiang, Tianhao Zou, Chuanzheng Wang, Weimin Wang, Mao Cai, Shuhua Zhang, Guoliang Wang, Huan Cao, et al.analysis, a set of primary antibodies targeting specific proteins was utilized: cleaved caspase-8 (8592; Cell Signaling Technology), cleaved caspase-3 (9664; Cell Signaling Technology), ADK (ab307357; Abcam),

(13) Fuzheng Jiedu formula attenuates acute pneumonia by coordinated regulation of macrophage NLRP3 inflammasome and neutrophil NETsChin MedJanuary 4, 2026Kaixin Liu, Jin Yan, Fuyun Chi, Wenshuang Wang, Man Zhang, Yuanyuan Hou, Gang Baifrom Abcam (Cambridge, UK). Antibodies against H3K9ac (9649), caspase-8 (4790), cleaved caspase-8 (8592) were sourced from Cell Signaling Technology (Beverly, USA). TNF-α (021825) was sourced from PeproTech

(14) Roll with the punches: Fibroblast growth factor 10 alleviates pyroptosis of alveolar epithelial cells in different immune nichesClinical and Translational MedicineJanuary 2, 2026Tianchang Wei, Xiaoyan Chen, Jian Xu, Weiqi Mao, Zhenlin Yang, Yuhan Wang, Yufan Li, Wenting Jin, Cuicui Chen, Cuiping Zhang, et al.caspase‐3 (Cell Signaling Technology, Cat: 9664T), cleaved caspase‐8 (Cell Signaling Technology; Cat: 8592T) and p‐RIPK1 (ThermoFisher; Cat: pa104645). 3.11 Cell culture and stimulation Immortalised macrophage

(15) RICH1 enhances pro-inflammatory TAM infiltration in breast cancer via promoting TRIM21-mediated ubiquitination of RhoA and inhibiting STAT3 phosphorylationnpj Precision OncologyDecember 23, 2025Yan Zhou, Huan Gao, Liyu Shan, Lizhe Zhu, Jiao Yang, Bo Wang, Juan Zhang, Ran Ran, Qi Tian, Peijun Liu, et al.against STAT3 (#9139, dilution 1:500), phosphor-STAT3Tyr705 (#9145, dilution 1:1000), Cleaved Caspase‑8 (#8592, dilution 1:500), and Pan-Cytokeratin (#4545, dilution 1:200) were purchased from Cell Signaling Technology.

(16) Caspase-8 expression in CD8+ T cells promotes pathogen restriction in the brain during Toxoplasma gondii infectionSci AdvDecember 12, 2025Lydia A. Sibley, Maureen N. Cowan, Abigail G. Kelly, NaaDedee A. Amadi, Isaac W. Babcock, Sydney A. Labuzan, Michael A. Kovacs, Samantha J. Batista, John R. Lukens, Tajie H. Harriscatalog no. ab52642), and cleaved caspase-8 (Asp387) (D5B2) (Cell Signaling Technology, catalog no. 8592T) (1:400). Secondary antibodies were used at 1:500 dilution. To stain Me49, ALDH1L1, GFAP, S100β, and

(17) Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosisCellDecember 11, 2025Yaqiu Wang, Jianlin Lu, Alexandre F. Carisey, Sangappa B. Chadchan, Ha Won Lee, R.K. Subbarao Malireddi, Bhesh Raj Sharma, Nagakannan Pandian, Rebecca E. Tweedell, Gustavo Palacios, et al.CST, 1:1000), cleaved caspase-7 (9491, CST, 1:1000), caspase-8 (4927, CST, 1:1000), cleaved caspase-8 (8592, CST, 1:1000), caspase-9 (CST, 9504, 1:1000), phospho-MLKL (Ser345, ab196436, Abcam, 1:1000), MLKL (AP14242B,

(18) ZBP1 orchestrates dynamic transitions between cell death pathways in response to arsenic and hyperosmotic stressJournal of Biological ChemistryDecember 1, 2025Yinghao Fu, Yifan Yang, Qingqing Li, Xin Xia, Menghan Peng, Shanshan Meng, Rong Shen, Yongyi Zhu, Huipeng Jiao, Chun Kim, et al.AC026), RIPK3 (CST, 15828s), CASP1 (AdipoGen, AG-20B-0042-C100), CASP3 (CST, 9662S), Cl-CASP8 (CST, 8592T), FL-CASP8 (ABclonal, A11324), CASP9 (Abcam, ab202068), GSDMD (Abcam, ab219800), GSDME (Abcam, ab215191),

(19) RIPK1 autophosphorylation at S161 mediates cell death and inflammationThe Journal of experimental medicineDecember 1, 2025Koerner L, Li X, Silnov E, Laurien L, Pasparakis M.(RRID: AB_2341188, Cat# 9661; Cell Signaling, Lot: 47), Cleaved-Caspase-8 (RRID: AB_10891784, Cat# 8592; Cell Signaling, Lot: 6), Caspase-8 (RRID: AB_10545768, Cat# 4790; Cell Signaling, Lot: 4), GAPDH (RRID:AB_10077627,

(20) NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injuryCell Death & DifferentiationNovember 19, 2025Sonia S. Shah, Jantina A. Manning, Yoon Lim, Diva Sinha, Ambika Mosale Venkatesh Murthy, Raja Ganesan, Nirmal Robinson, Emad S. Alnemri, Seth L. Masters, James E. Vince, et al.Cell Signaling Technology); anti-caspase-1 (Casper-1, AG-20B-0042, AdipoGen Life Sciences); anti-cleaved caspase-8 (8592, Cell Signaling Technology, Beverly, MA, USA) and anti-NLRP3 (D4D8T, Cell Signaling Technology); anti

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Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb (Mouse Specific)

Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Cleaved Caspase-8 (Asp387) (D5B2) XP ® Rabbit mAb from Cell Signaling Technology

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