MyBioSource.com's Mouse Anti-XRCC1 Antibody is a Mouse monoclonal antibody. The Mouse Anti-XRCC1 Antibody was generated using XRCC1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair