Rat Anti-Mouse CD86/B7-2-PE MBS673454 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD86/B7-2-PE
CompanyMyBioSource.com
Price $255.00Supplier Page View Company Product Page
Catalog NumberMBS673454
Conjugate/TagR - phycoerythrin (R - PE)
CloneGL1
ClonalityMonoclonal
Quantity0.1 mg
ApplicationsFlow Cytometry; Immunohistochemistry (Frozen Sections); Immunoprecipitation
ImmunogenMouse CD86, the B7-2 co-stimulatory molecule and a ligand for CD28 and CD152/CTLA-4
CD86, also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes.^1-5 CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation.^1, 5 CD86, along with CD80/B7-1, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA-4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response.^1-9 The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells.^1, 3, 5
ReactivityMouse
IsotypeIgG2a kappa
FormatR - phycoerythrin (R - PE) Conjugate
HostRat
Antibody TypeSecondary
TargetCD86/B7-2