MyBioSource.com's MOUSE ANTI MDM2 Antibody is a Mouse monoclonal antibody. The MOUSE ANTI MDM2 Antibody was generated using Hdm2, MDM2, and MDM2 proto-oncogene as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Immunoprecipitation.
Description
Mouse anti MDM2 antibody, clone SMP14 recognizes the 90kDa MDM2 protein, which forms a complex with p53 leading to p53 inhibition. MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI. MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer