MyBioSource.com's RAT ANTI MOUSE DECTIN-2:Low Endotoxin Antibody is a Rat monoclonal antibody. The RAT ANTI MOUSE DECTIN-2:Low Endotoxin Antibody was generated using C-type lectin domain family 4, member n, and Clec4n as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, and Immunoprecipitation.
Description
Rat anti Mouse Dectin-2 antibody, clone D2.11E4 recognizes mouse DC-associated C-type lectin-2 (Dectin-2), a type II transmembrane protein that is a member of the C-type lectin superfamily. In mouse, dectin-2 is predominantly expressed on tissue macrophages and some dendritic cells. Clone D2.11E4 does not stain brain microglia or meningeal macrophages. Significant expression of Dectin-2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin-2 but transient up-regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin-2 has not been fully determined but studies suggest a possible role in immune-surveillance