Rat Anti-Mouse CD16/32-APC MBS673332 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD16/32-APC
CompanyMyBioSource.com
Price $320.00Supplier Page View Company Product Page
Catalog NumberMBS673332
ClonalityMonoclonal
Conjugate/TagAllophycocyanin (APC)
IsotypeIgG2a
Clone93
TargetCD16/32 (Fc gamma Receptor)
Quantity0.1 mg
ImmunogenMurine CD16/32 (CD16/Fc gamma II and CD32/Fc gamma III receptors)
The lymphocyte Fc gamma receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta.^1, 2 The Fc gamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios.^1 The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression.^4 Besides identifying Fc gamma R^+ cells, monoclonal antibodies to the Fc gamma II/III receptor have been used to block Fc receptor binding of IgG, Fcmediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc gamma R for parasitic invasion.^4-6 The monoclonal antibody 93 recognizes a conformational epitope formed by Fc gamma II and Fc gamma III receptors
ApplicationsFlow Cytometry
HostRat
FormatAllophycocyanin (APC) Conjugate
ReactivityMouse
Antibody TypeSecondary