Megalin Polyclonal Antibody bs-3909R from Bioss Inc.

Product Specs
ItemMegalin Polyclonal Antibody
CompanyBioss Inc.
Price $375.00Supplier Page View Company Product Page
Catalog Numberbs-3909R
Molecular Weight519kDa
ImmunogenKLH conjugated peptide, human Megalin
ClonalityPolyclonal
Antibody TypePrimary Antibody
IsotypeIgG
Format0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol
Quantity100ul, 20uL
Conjugate/TagUnconjugated
ApplicationsELISA, FCM, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), Others
ReactivityHuman, Mouse, Rat, Mouse
HostRabbit
TargetLrp2/Megalin
Concentration1ug/ul
NCBI Gene AliasesGP330, DBS, LRP-2
NCBI Full Gene NameLDL receptor related protein 2

Questions and Answers

Can this antibody be used to study megalin expression in kidney cells?

Yes, the Megalin Polyclonal Antibody has been utilized to analyze megalin expression in human kidney HK2 cells. In a study, the antibody was applied to both parent and LRP2 knockout cells, followed by flow cytometry to assess binding and expression levels, confirming its effectiveness in this context ().

Is this antibody suitable for use in flow cytometry applications?

The Megalin Polyclonal Antibody has been shown to work effectively in flow cytometry. In the referenced study, it was used to detect megalin levels in genetically modified cells, demonstrating its utility for this application ().

What species does this antibody react with, and is it applicable for human studies?

This antibody is reactive with both human (Homo sapiens) and mouse (Mus musculus) species. Its application in human studies is supported by its use in experiments involving human kidney cells, making it suitable for research involving human biological samples.

Are there any specific experimental conditions or techniques recommended for using this antibody?

The antibody has been effectively used in immunocytochemistry and flow cytometry, with specific conditions including blocking with bovine serum albumin and incubation with the antibody followed by secondary staining. These methods were detailed in a study that confirmed the antibody's binding and functionality in detecting megalin in cell models ().

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Website: www.biossusa.com

(1) Sodium-glucose cotransporter 2 inhibitors alleviate renal fibrosis in diabetic kidney disease by inhibiting Hmgcs2 and Btg2 in proximal tubular cellsJ Transl MedAugust 25, 2025Shengzhe Yan, Minhui Luo, Rui Zhou, Fenfen Peng, Mingze Zhang, Yujie Feng, Liang Zhao, Li Yang, Yanzhen Chenggroup. Immunofluorescence Immunofluorescent staining was conducted utilizing antibodies against Lrp2(bs-3909R, Bioss,1:200), Slc5a2, Hmgcs2 (bs-5070R, Bioss, 1:200), Btg2 (22339-1-AP, proteintech, 1:200) and Treble-Fluorescence

(2) Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell modelEJNMMI radiopharmacy and chemistryApril 18, 2024Durinova A, Smutna L, Barta P, Kamaraj R, Smutny T, Schmierer B, Pavek P, Trejtnar F.(5% in PBS) for 90 min. The blocked cells were incubated with 0.05 ng/mL megalin polyclonal antibody (bs-3909R, Bioss Antibodies) for 2 h followed by secondary anti-rabbit CF™ 594antibody staining (5 µg/mL, 1h;

(3) Role of serotonin in the regulation of renal proximal tubular epithelial cellsRenal failureAugust 1, 2016Erikci A, Ucar G, Yabanoglu-Ciftci S.

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Megalin Polyclonal Antibody

Megalin Polyclonal Antibody from Bioss Inc.

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Questions and Answers

Bioss Inc.

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Megalin Polyclonal Antibody from Bioss Inc.

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