The RAT ANTI EPSTEIN-BARR VIRUS LMP2A Antibody from MyBioSource.com is a Rat Monoclonal antibody. The RAT ANTI EPSTEIN-BARR VIRUS LMP2A Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
Rat anti Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV). EBV is a human herpesvirus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. MBS212822 specifically recognizes LMP2A and does not cross react with LMP2B