Fig 2: Built-up prognostic nomogram for RFS prediction and calibration for it(A) showed a seven independent prognostic factors including tumor size, pathologic T stage, Fuhrman grade, the presence of coagulative necrosis and lymphovascular invasion and FUT3 expression. The total point was generated by adding the scores of the prognostic factors. (B-D) showed the calibration plot for nomogram predicted 1-year, 3-year and 5-year recurrence free survival rate.

Fig 3: Built-up prognostic nomogram for OS prediction and calibration for it(A) showed an eight independent prognostic factors including tumor size, pathologic T, N, M stage, the presence of coagulative necrosis and lymphovascular invasion and FUT3 expression. The total point was generated by adding the scores of the prognostic factors. (B-D) showed the calibration plot for nomogram predicted 1-year, 3-year and 5-year overall survival rate.

Fig 4: Multivariate analyses of conventional prognostic features in OS and RFSFigure 3 showed hazard ratio and p-value of each clinical and pathologic feature for OS and RFS. Abbreviation: LVI, lymphovascular invasion; ECOG-PS, Eastern cooperative Oncology Group performance status; FUT3, fucosyltransferase-III.

Fig 5: Representative photograph of FUT3 immunostaining in TMA (magnification * 200, scale bar = 100 μm)(A) showed low densities of FUT3 while (B) showed high densities of FUT3.