SignalStain ® Boost IHC Detection Reagent (HRP, Rabbit) 8114P from Cell Signaling Technology

Product Specs
ItemSignalStain ® Boost IHC Detection Reagent (HRP, Rabbit)
CompanyCell Signaling Technology
Price $53.00 Inquire
Catalog Number8114P
Quantity1 ml
Conjugate/TagHRP
Research AreaRelated Products
ApplicationsIHC-p
Source/Expression SystemGoat
ReactivityRab

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

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(1) JIN-A02, a Mutant-Selective Fourth-Generation EGFR Inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLCClinical Cancer ResearchMay 1, 2026Eun Ji Lee, Ji Ae Ko, Min-je Kim, Jae Seok Cho, Ji-Youn Han, Sang We Kim, Ki Hyeong Lee, Byoung Yong Shim, Jong-Mu Sun, Misako Nagasaka, et al.(pH 7.4) and incubated for 30 minutes with SignalStain Boost IHC detection reagent (HRP, rabbit; no. 8114; Cell Signaling Technology, RRID: AB_10544930). After additional washes, immunoperoxidase staining was

(2) Inhibitory role of angiopoietin‑like 4 for cancer progression in oropharyngeal squamous cell carcinomaOncol RepApril 20, 2026Takuya Mikoshiba, Mariko Sekimizu, Nana Nakahara, Shin Saito, Keisuke Yoshihama, Ryoto Nagai, Takeyuki Kono, Hiroyuki Ozawaovernight at 4°C. They were washed and incubated with SignalStain® Boost IHC Reagent (HRP; Rabbit; cat. no. 8114; Cell Signaling Technology, Inc.) for 30 min at room temperature. Peroxidase activity was visualized

(3) Chronic replication stress-mediated genomic instability disrupts placenta development in micePLoS GenetApril 13, 2026Mumingjiang Munisha, Rui Huang, Jordan Khan, John C. Schimenti4⁰C. Rabbit primary antibodies were detected with SignalStain Boost IHC detection reagent (CST Cat#: 8114). Sections were dipped into Hematoxylin Gill II (Leica Biosystems) for 20 seconds followed by 5 minutes

(4) Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cellsbioRxivApril 6, 2026Courtney M. Tamaki, Chester E. Chamberlain, Clare L. Abram, Sumith Poojary, Jennifer Bridge, Jennifer L. Matsuda, Whitney Tamaki, Niklas Rutsch, Lauren Spector, Wesley Dixon, et al.washed in TBS-T twice and then incubated with anti-rabbit HRP secondary (Signal Stain(R) Boost Cat # 8114S Cell Signaling Tech) for 1 hour. Slides were washed in TBS-T 3 times for 5 min and detected with DAB

(5) Inhibition of Autophagy Reveals ATR Protein Kinase as a Key Mediator of Cisplatin Sensitivity in OsteosarcomaCancer MedMarch 5, 2026Janice S. Pereira, Gabriel Rosa, Aine Pears, Beata Burczynska, Britta Stordal, Scott J. Roberts, Helen C. Robertsthe slide, the secondary antibody (SignalStain Boost Detection Reagent, Cell Signaling Technology, 8114) was applied for 30 min at RT and stained with SignalStain DAB Substrate Kit (Cell Signaling Technology,

(6) CGRP signaling links tumor-associated pain to immune evasion in oral squamous cell carcinomaCell ReportsFebruary 24, 2026Lisa A. McIlvried, Andre A. Martel Matos, Rachel S. Krane, Kathryn T. Eskew, Tian LeGrande, Megan A. Atherton, Morgan A. Ottley, Marci L. Nilsen, Diana Bell, Maryam Ahmadi, et al.Anti-S100,Agilent,PA0031U; RRID: AB_2755010 "SignalStain Boost (Horseradish Peroxidase (HRP), Rabbit)",Cell Signaling,8114; RRID: AB_10544930 Goat anti-rabbit Alexa Fluor 594,Jackson ImmunoResearch,111585006; RRID: AB_2338060 Goat

(7) GSPT1-specific protein degradation is effective in preclinical models of chemoresistant MYCN-amplified neuroblastomaJournal of Experimental & Clinical Cancer ResearchFebruary 6, 2026Aleksandra Adamska, Hanna Chahin, Erick Andrés Muciño-Olmos, Javanshir Esfandyari, Kristina Aaltonen, Sofia Granados-Aparici, Joachim Tetteh Siaw, Katarzyna Radke, Chiara Lago, Paweł Pasikowski, et al.Invitrogen, #MA5-32123). HRP-conjugated secondary antibody solutions (Cell Signaling; anti-rabbit: #8114S, anti-mouse: #8125S) were used for 1 h at RT for. ImmPACT DAB solution (Vector, #SK-4105) was applied

(8) Metformin suppresses MEN1-associated pancreatic and pituitary neuroendocrine tumors: evidence from mouse models and clinical dataEndocrine-Related CancerFebruary 1, 2026Airi Nakano, Yao Huang, Yuri Mistui, Ryunosuke Shirai, Yu Chen, Tomoko Tajima, Yukiko Sakaguchi, Tomoka Moro, Chihiro Hoshino, Kosuke Terada, et al.anti-mouse IgG (VECTOR Laboratories, USA; 1:500). SignalStain Boost Detection Reagent (HRP, Rabbit #8114, Cell Signaling Technology, USA) was also used as appropriate. Staining was visualized using 3,3′-diaminobenzidine

(9) Isolation and Characterization of Peritoneal Macrophages from SalamandersMethods in Molecular BiologyJanuary 14, 2026Anthony Sallese, Georgios Tsissios, José Raúl Pérez-Estrada, Arielle Martinez, Katia Del Del Rio-Tsonis#3154S) at 1:200 dilution. 2.2.4.1.2. Signal Stain boost IHC Detection, Rabbit HRP (Cell Signalling #8114S). 2.2.4.4. Permount mounting medium (Fisher #SP15–500). 2.2.5. RT-qPCR 2.2.5.1. TRIzol reagent (ThermoFisher,

(10) Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancerBreast Cancer ResearchJanuary 11, 2026Jessica Pantaleo, Jonas Sjölund, Paulina Bolivar, Matteo Bocci, Bengt Phung, Maria Malmberg, Göran B. Jönsson, Kristian PietrasRT","30 min, RT","30 min, RT","30 min, RT","30 min, RT","30 min, RT" Secondary antibody,Cell signaling #8114S,Cell signaling #8114S,Cell signaling #8114S,Cell signaling #8114S,Cell signaling #8114S,Cell signaling

(11) Acute Phase Response-driven Hepatic Niche Remodeling Promotes Fibrosis Resolution After Alcohol CessationCellular and Molecular Gastroenterology and HepatologyJanuary 1, 2026Michael Schonfeld, Kruti Nataraj, Samson Mah, Wei Zhong, Steven A. Weinman, Irina TikhanovichProtein Block at 4°C. Antigen was detected using the SignalStain Boost IHC detection reagent (catalogue # 8114; Cell Signaling Technology, Beverly, MA), developed with diaminobenzidene (DAB; Dako), counterstained

(12) SIGLEC15 modulates the immunosuppressive microenvironment and suppresses malignant phenotypes in triple-negative breast cancerGenes & diseasesJanuary 1, 2026Tan Z, Xin H, Chen J, Lei M, Tu G, Tang L.the slides were incubated with SignalStain Boost IHC Detection Reagent (Cell Signaling Technology, 8114) for 30 min at room temperature. After washing three times with 0.1% TBS-T, the signal was developed

(13) Targeting mTORC1 to promote ferroptosis and apoptosis in endometrial cancer with PI3K-Akt-mTOR pathway mutationFerroptosis and Oxidative StressDecember 29, 2025Yingying Hu, Pei Liu, Neal Rosen, Xuejun Jiangslides were incubated with SignalStain® Boost IHC Detection Reagent (HRP) (Cell Signaling Technology 8114S for Rabbit or 8125P for Mouse) for 30 min. Slides were then stained with the SignalStain® DAB Substrate Kit

(14) Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancerCell Rep MedDecember 16, 2025Jody Vykoukal, Yihui Chen, Mingxin Zuo, Riccardo Ballarò, Monica J. Hong, Hansini Krishna, Daniela B. Rodriquez-Perera, Hiroyuki Katayama, Ehsan Irajizad, Ranran Wu, et al.followed by incubation in HRP rabbit polymer conjugated secondary antibody (Cell Signaling, catalog#8114S). The immunoreaction was visualized in Histofine DAB-2V Kit (Nichirei Bioscience, Tokyo, Japan, catalog#425314F)

(15) Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapyCell Reports MedicineDecember 16, 2025Yulei Wang, Yinghui Guan, Alexander R. Abbas, Yuji Sano, Saket Jain, Shan Lu, Habib Hamidi, Hartmut Koeppen, Yumiko Azuma, Yoko Kayukawa, et al.EP1674Y, Abcam, Cambridge, MA) and SignalStain Boost IHC Detection Reagent (HRP, Rabbit) (Catalog #8114, Cell Signaling Technologies, Danvers, MA) were used to detect nuclear signals of YAP protein. Slides

(16) Effect of fish scale ointment on diabetic foot ulcer by inducing ferroptosis via the nuclear factor E2-related factor 2 pathwayWJDDecember 15, 2025Lin Li, Xiao-Na Liu, Shuang Guo, Yan-Ling Ju, Lan-Yue Guo, Chun-Hua Zhang, Jin-Jun Wang46879S, 1:500] and CD31 (No. 77699S; 1:200), followed by incubation with a secondary antibody (No. 8114) at 37 °C for 60 minutes. All antibodies were supplied by Cell Signaling Technology. After 3,3’-diaminobenzidine

(17) Dendrobine promotes bone formation via the canonical Wnt/β-catenin signaling pathway and prevents postmenopausal osteoporosisFront PharmacolDecember 3, 2025Shengfa Li, Peili Liang, Jian Chen, Youming Zhang, Haixiong Miao, Ting Wangantibodies were removed by PBS, and the sections were incubated with secondary antibodies (Product No.: 8114, dilution rate: 1:150, CST) for 1 h at room temperature (RM). The secondary antibody was removed by

(18) The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failureToxicological SciencesDecember 1, 2025David S Umbaugh, Nga T Nguyen, Steven C Curry, Jody A Rule, William M Lee, Anup Ramachandran, Hartmut Jaeschke, Acute Liver Failure Study Group, Shannan Tujios, David Koch, et al.overnight at 4°C. The next day SignalStain Boost detection reagent (Cell Signaling Technologies, No. 8114) was added for 30 min, followed by visualization using SignalStain Dab Chromogen concentrate (Cell Signaling Technologies

(19) MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexiaCancer Research CommunicationsDecember 1, 2025Katherine R. Pelz, Philip Jimenez, Colin J. Daniel, Samuel D. Newton, Melissa Cunningham, Rosalie C. Sears, Patrick J. Worth, Jonathan R. Brody, Teresa A. ZimmersAB_11182183, rabbit, 1:400) and either 3,3′diaminobenzidine-conjugated (Cell Signaling Technology, cat. #8114, RRID: AB_10544930, goat anti-rabbit) or alkaline phosphatase (AP)–conjugated (Vector Laboratories,

(20) Host cysteine proteases promote the severity of catheter-associated urinary tract infection and kidney fibrosismBioNovember 12, 2025Wei Xu, Jian Chen, Lisa K. McLellan, Ana L. Flores-Mireles, David A. Hunstad, Michael G. Caparonpotential E64 targets were performed using the SignalStain IHC kit (Cell Signaling Technology, cat. #8114) according to the manufacturer’s protocol. IHC analyses of E. faecalis were performed as described previously

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SignalStain ® Boost IHC Detection Reagent (HRP, Rabbit)

SignalStain ® Boost IHC Detection Reagent (HRP, Rabbit) from Cell Signaling Technology

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Cell Signaling Technology

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SignalStain ® Boost IHC Detection Reagent (HRP, Rabbit) from Cell Signaling Technology

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