Phospho-ALK (Tyr1278) (D59G10) Rabbit mAb 6941S from Cell Signaling Technology

Product Specs
ItemPhospho-ALK (Tyr1278) (D59G10) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number6941S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetALK (Tyr1278) phosphate
ModificationsALK (Tyr1278) phosphate
HostRabbit
NCBI Gene AliasesALK1, CD246, NBLST3
ClonalityMonoclonal
NCBI Full Gene NameALK receptor tyrosine kinase
Research AreaRTK
IsotypeIgG
CloneD59G10
Molecular Weight80 (NPM-ALK); 220 (ALK)

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Novel activating SNRNP70-ALK fusion in congenital infant-type hemispheric glioma displays clinical response to lorlatinib: a case-reportnpj Precision OncologyFebruary 26, 2026Cecilia Arthur, Kleopatra Georgantzi, Teresita Díaz de Ståhl, Jikui Guan, Blaz Oder, Cecilia Jylhä, Christopher Illies, Johanna Sandgren, Jan Svoboda, Jesper Eisfeldt, et al.(mAb) from BD Transduction Laboratories (Franklin Lakes, NJ); anti-pALK (Y1278) (D59G10) rabbit mAb (#6941), anti-ALK (D5F3) rabbit mAb (#3633), anti-pERK1/2 (T202/Y204) (D13.14.4E) rabbit mAb (#4370), anti-pAKT

(2) ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical modelsiScienceMay 17, 2024Bugide S, Reddy DS, Malvi P, Gupta R, Wajapeyee N.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, ACTINB,Cell signaling,Cat# 4970; RRID: AB_2223172 p-ALK (Tyr1278),Cell Signaling,Cat# 6941; RRID: AB_10860598 ALK,Santa Cruz Biotechnology,Cat# sc-398791; RRID: AB_2889357 p-AKT (Ser473),Cell Signaling

(3) MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGFJCI InsightDecember 22, 2023Nobuyuki Kondo, Takahiro Utsumi, Yuki Shimizu, Ai Takemoto, Tomoko Oh-hara, Ken Uchibori, Sophia Subat-Motoshi, Hironori Ninomiya, Kengo Takeuchi, Makoto Nishio, et al.Cell Signaling Technology: total EGFR (4627, 1:1,000), total ALK (3633, 1:2,000), phospho-ALK (Y1604, 3341, 1:1,000. Y1278, 6941, 1:1,000), total ROS1 (69D6, 3266, 1:2,000), phospho-ROS1 (Y2274, 3078, 1:1,000), total AKT (4691, 1:1,000),

(4) Autocrine EGF and TGF ‐α promote primary and acquired resistance to ALK / c‐Met kinase inhibitors in non‐small‐cell lung cancerPharmacology Research & PerspectivesFebruary 1, 2023Yueqin Wang, Yu Zhang, Ruiying Chen, Xin Tianphospho‐EGFR Tyr1068 (1:1000, #3777, CST), EGFR (1:1000, #4267, CST), phospho‐ALK Tyr1278 (1:1000, #6941, CST), ALK (1:2000, #3633, CST), phospho‐Akt Ser473 (1:2000, #4060, CST), Akt (1:1000, #4685, CST),

(5) Structural basis of cytokine-mediated activation of ALK family receptorsNatureDecember 1, 2021De Munck S, Provost M, Kurikawa M, Omori I, Mukohyama J, Felix J, Bloch Y, Abdel-Wahab O, Bazan JF, Yoshimi A, et al.Cell Signaling Technologies; catalogue no. 3633; dilution: 1:1,000), phospho-ALK (Tyr1278) (Cell Signaling Technologies; 6941; 1:250), phospho-ALK (Tyr1604) (Cell Signaling Technologies; 3341; 1:250), phospho-p44/42 MAPK (Erk1/2)

(6) Translational Strategies for Repotrectinib in NeuroblastomaMolecular cancer therapeuticsNovember 1, 2021O'Donohue TJ, Ibáñez G, Coutinho DF, Mauguen A, Siddiquee A, Rosales N, Calder P, Ndengu A, You D, Long M, et al.standard methods. Membranes were probed with the following primary antibodies: phospho-ALK (Y1278) (#6941; Cell Signaling Technologies, CST, RRID:AB_10860598), phospho-ALK (Y1586) (#3348; CST, RRID:AB_659803),

(7) Non-canonical roles of canonical telomere binding proteins in cancersCellular and Molecular Life SciencesMay 1, 2021Semih Can Akincilar, Claire Hian Tzer Chan, Qin Feng Ng, Kerem Fidan, Vinay Tergaonkarmaintenance of telomere length in squamous cell carcinoma of the esophagus. World J Gastroenterol 11(44):6941–6947 259. Amir M et al (2020) Structural features of nucleoprotein CST/ shelterin complex involved in

(8) Binge‐like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortexGenes, Brain and BehaviorMarch 16, 2021Kana Hamada, Laura B. Ferguson, R. Dayne Mayfield, Harish R. Krishnan, Mark Maienschein‐Cline, Amy W. Lasekdilution; ALK #381518, 1:500 dilution; phosphorylated ALK (pALK, Y1278), Cell Signaling Technology #6941, RRID: AB_10860598, 1:500 dilution; and β-actin, Sigma-Aldrich #A5441, RRID: AB_476744, 1:10,000 dilution.

(9) Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesisLife science allianceFebruary 1, 2021Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, et al.following antibodies were used for protein expression analysis: ALK (D5F3, CST #3633), pALK (Tyr1278, CST #6941), STAT3 (D3Z2G, CST #12640), pSTAT3 (Tyr705, CST #9145), DNMT1 (H300, sc-20701), CDK4 (C-22, sc-260;

(10) Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 ReceptorMolecular pharmacologyFebruary 1, 2020He D, Lasek AW.51-3900, 1:1000; Thermo Fisher Scientific), anti-pALK (phosphotyrosine 1278, clone D59G10; cat. no. 6941, 1:1000; Cell Signaling Technology), anti-pPKCg (phosphothreonine 514, clone EP2730Y, cat. no. ab109539,

(11) Proteomic Methods to Evaluate NOX-Mediated Redox SignalingMethods in molecular biology (Clifton, N.J.)January 1, 2019Dustin CM, Hristova M, Schiffers C, van der Vliet A.Redox regulation of protein tyrosine phosphatase 1B involves a sulphenylamide intermediate. Nature 423(6941):769–773. [PubMed: 12802338] 10. Barrett WC, et al. (1999) Regulation of PTP1B via glutathionylation

(12) Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cellsBMC Cell BiologyDecember 1, 2018Ahlima Roumane, Kevin Berthenet, Chaïmaa El Fassi, Gabriel Ichim

(13) Exercise-induced mitochondrial biogenesis coincides with the expression of mitochondrial translation factors in murine skeletal musclePhysiological reportsOctober 1, 2018Yokokawa T, Kido K, Suga T, Isaka T, Hayashi T, Fujita S.

(14) Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based PeptideNeoplasia (New York, N.Y.)June 1, 2018Pittala S, Krelin Y, Shoshan-Barmatz V.

(15) Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against NeuroblastomaClinical cancer research : an official journal of the American Association for Cancer ResearchJune 1, 2017Wood AC, Krytska K, Ryles HT, Infarinato NR, Sano R, Hansel TD, Hart LS, King FJ, Smith TR, Ainscow E, et al.and immunoblotted against pALKY1604 [Cell Signaling Technology, catalog numbers 3341S], pALKY1278 [6941S], total ALK [3333S], pRbS795 [9301S], pRbS780 [9307S], total Rb [9309S], Cyclin-D1 [2922S], Cleaved

(16) ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosisOncotargetJuly 12, 2016Jessica L. Weatherbee, Jean-Louis Kraus, Alonzo H. Ross

(17) Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brainJournal of neurochemistryNovember 1, 2015He D, Chen H, Muramatsu H, Lasek AW.signaling pathways. Materials and methods Materials Antibodies to phosphorylated ALK (pALK, Tyr 1278, #6941), ERK1/2 (#9102), phosphorylated ERK1/2 (pERK, Thr 202/Tyr 204, #4370), STAT3 (#12640), and phosphorylated

(18) Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitorsProceedings of the National Academy of Sciences of the United States of AmericaSeptember 29, 2015Davare MA, Vellore NA, Wagner JP, Eide CA, Goodman JR, Drilon A, Deininger MW, O'Hare T, Druker BJ.(9101, 1:1,000; CST), total ERK2 (sc-1647, 1:2,000; Santa Cruz), total ALK (3333, 1:1,000; CST), phospho-ALK (6941, 1:1,000; CST), phospho-Akt (4060, 1:1,000; CST), AKT (610860, 1:1,000; BD Transduction Laboratories),

(19) Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cellsFEBS JournalNovember 1, 2013Kamaraj Sattu et al.The antibodies used were anti-STAT3 (#9132), anti-p-STAT3 (Tyr705) (#9145), anti-p-ALK (Tyr1278) (#6941), anti-p-ERK (phospho-p44/42) (#9101), anti-N-MYC (#9405) (all Cell Signaling Technology, MA, USA),

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Phospho-ALK (Tyr1278) (D59G10) Rabbit mAb

Phospho-ALK (Tyr1278) (D59G10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (19)

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Phospho-ALK (Tyr1278) (D59G10) Rabbit mAb from Cell Signaling Technology

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