Met (D1C2) XP ® Rabbit mAb 8198S from Cell Signaling Technology

Product Specs
ItemMet (D1C2) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $402.00 Inquire
Catalog Number8198S
Quantity100 µl
ApplicationsW, W-S, IP, IHC-Bond, IHC-P, IF-IC, FC-FP
ReactivityH
TargetMet
HostRabbit
NCBI Gene AliasesAUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met
ClonalityMonoclonal
NCBI Full Gene NameMET proto-oncogene, receptor tyrosine kinase

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signalingSci AdvMay 1, 2026Huimin Qin, Liuwei Chu, Xiaying Zheng, Huimei Zhang, Yue Lan, Ji Hu, Lu Liprimary antibodies at 4°C overnight. Primary antibodies included c-MET (1:500; Cell Signaling Technology, 8198), β-catenin (1:200; Proteintech, 51067-2-AP), AKT (1:1000; Santa Cruz, sc-5298), RAS (1:500; Cell Signaling Technology

(2) A degrader of HER2 and EGFR abolishes p95HER2 and shows robust antitumor efficacy in HER2-positive breast cancerSci RepApril 20, 2026Lu Yang, Arup Bhattacharya, Yun Li, Darrell Peterson, Yuesheng Zhanganti-pY1068-EGFR (Cat # 2236), anti-HER2 (Cat# 2165), anti-pY1221/1222-HER2 (Cat # 2243), anti-MET (Cat # 8198), anti-pY1234/1235-MET (Cat #gene 3077), anti-AKT (Cat # 4691), anti-pS473-AKT (Cat # 4060), anti-extracellular

(3) DNA delivered by lipid nanoparticles induces CD8+ T cell–dependent antitumor responses and enhances anti–PD-L1 therapyJCI InsightMarch 23, 2026Seoyun Yum, Alba Rodríguez-Garcia, Joan Castellsagué, Marta Giménez-Alejandre, Guillem Colell, Salut Colell, Teresa Lobo-Jarne, Mark A. LaRue, Michael A. Minnier, Mustafa N. Yazicioglu, et al.slides cut from the blocks were stained for catenin β-1 (dil 1:75, 8480, clone D10A8), MET (dil 1:100, 8198, clone D1C2), mouse CD8A (dil 1:500, 98941, clone D4W2Z), and mouse MKI67 (dil 1:800, 12202, clone D3B5).

(4) A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLCCell Oncol (Dordr)January 27, 2026Yuanyuan Wang, Haoyue Guo, Ruoshuang Han, Yuhan Wu, Taiping He, Meng Diao, Anwen Xiong, Fei Zhou, Lei Cheng, Chao Zhao, et al.anti-Phosphorylated-EGFR Antibody (CST, Cat#3777S, 1:1000, RRID: AB_2096270), anti-MET Antibody (CST, Cat# 8198 S, 1:1000, RRID: AB_10858224), anti-Phosphorylated-MET Antibody (CST, Cat#3077S, 1:1000, RRID: AB_2143884),

(5) Novel NOTCH2-NTRK1 fusion confers osimertinib resistance in EGFR-mutant non-small cell lung cancer by interacting with EGFRTranslational OncologyJanuary 1, 2026Hui Li, Huiting Wei, Tiantian Zhen, Huabin Gao, Huicong Liu, Shuai Zheng, Huijuan Shi, Jiangtao Liang, Fenfen Zhang, Jiecheng Ye, et al.HA (C29F4) (#3724), EGFR (D38B1) (#4267), phosphorylated EGFR (Thr669) (D2F1) (#8808), Met (D1C2) (#8198) and phosphorylated TRKA (Tyr490) (#4619) were purchased from Cell Signaling Technology. The anti-GAPDH

(6) Huang-qin decoction increases the sensitivity of EGFR-TKIs to NSCLC cells by regulating stat3/GPX4 to induce redox ratio and ROS to inhibit CSCsJournal of Traditional and Complementary MedicineJanuary 1, 2026Yaya Yu, Chenjing Lei, Yanan Li, Changju Ma, Lina Ding, Zhenzhen Xiao, Qing Tang, Yadong Chen, Ruidi Jiang, Yisheng Su, et al.dehydrogenase 1 family, member A1 (ALDH1A1, 36,671), GPX4 (59,735), stat3 (12,640), p-stat3 (3077), MET (8198), p-MET (3077) and GAPDH (2118) were purchased from Cell Signaling Technology (USA). ROS assay kit (S0033S)

(7) Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK –driven lung cancer by concurrent integrin and MET signalingScience SignalingDecember 23, 2025Qianqian Hu, Lily L. Remsing Remsing Rix, Bina Desai, Daria Miroshnychenko, Xueli Li, Eric A. Welsh, Bin Fang, Gabriela M. Wright, Neelkamal Chaudhary, Jodi L. Kroeger, et al.Technology [CST], #3633, RRID:AB_11127207), pALK (Tyr1604) (CST, #3341, RRID:AB_331047), total MET (CST, #8198, RRID:AB_10858224), pMET (Tyr1234/1235) (CST, #3077, RRID:AB_2143884), total AKT (CST, #9272, RRID:AB_329827),

(8) Single-cell and spatial transcriptomic characterization of pulmonary pleomorphic carcinomaCommun BiolDecember 16, 2025Atsushi Matsuoka, Kazuhiko Shien, Shuta Tomida, Masayoshi Ohki, Kazuya Hisamatsu, Ryota Fujiwara, Kosei Ishimura, Ryunosuke Fujii, Tomoaki Higashihara, Naohiro Hayashi, et al.min and incubated overnight at 4 °C with a c-MET primary antibody (Cell Signaling Technology; Cat. #8198; dilution 1:150). Sections were incubated for 30 min with the ImmPRESS VR Polymer HRP Anti-Rabbit IgG

(9) The Prolyl Isomerase PIN1 Affects Fibroblast Differentiation States and Cross-talk in Pancreatic CancerCancer ResearchDecember 15, 2025Chloe L. Bowman, Colin J. Daniel, Eric J. Carlson, Vidhi M. Shah, Amy S. Farrell, Kayleigh M. Kresse, Xiaoyan Wang, Kyra A. Lindley, Madeline R. Kuhn, Kevin MacPherson-Hawthorne, et al.Cell Signaling Technology Cat#3077, RRID AB_2143884, 1:200) or tMET (D1C2; Cell Signaling Technology Cat# 8198, RRID AB_10858224, 1:150) were diluted in blocking buffer and tissues incubated overnight at 4°C. Sections

(10) Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma modelsNature CommunicationsNovember 5, 2025Connor A. Ott, Timothy J. Purwin, Pan-Yu Chen, Somenath Chowdhury, George L. Mellor, Kristine Luo, Glenn L. Mersky, Manoela Tiago, William D. Madden, Scott D. Varney, et al.FOXM1 (#5436, 1:1000), PAI-1 (#49536, 1:1000), and P-c-Met (Tyr1234/1235) (#3077, 1:1000), and c-Met (#8198, 1:1000), PLK1 (#4513S, 1:1000), RAD51 (#8875, 1:1000), and AXL (#8661, 1:1000) were purchased from

(11) The lysosomal cysteine protease cathepsin L promotes stemness and multidrug resistance of non-small cell lung cancer by targeting HGF activatorMolecular and Cellular BiochemistryNovember 3, 2025Hui Shi, Jianyu Xu, Juan Wu, Sha Hu, Xi Chen, Qianfang Hu, Qian Liu, Yanxia Yu, Xinyuan Ding, Wenjuan WangUK). Primary antibody against SOX2 (#23,064), Mcl-1 (#94,296), Bcl-2 (#4223), HGF (#52,445), Met (#8198), Phospho-Met (#3077), Flag (#14793 T), and GAPDH (#97166) were purchased from Cell Signaling Technology

(12) IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non-small cell lung cancerMol CancerOctober 28, 2025Ritsu Ibusuki, Eiji Iwama, Atsushi Shimauchi, Hiromu Kawano, Shun Mizusaki, Satoshi Nakamura, Yui Miyazaki, Yu Inutsuka, Mikiko Hashisako, Taishi Harada, et al.phospho-AKT (#9271), to AKT (#9272), to the DYKDDDDK Flag tag (#14793), to phospho-MET (#3077), to MET (#8198), to phospho-GSK3β (#9323), to GSK3β (#9315), to phospho-mTOR (#5536), to mTOR (#2983), or to β-actin

(13) PTEN loss and ERBB2/ERBB3-mediated AKT reactivation drive resistance to MET inhibition in MET-amplified hepatocellular carcinomaCell Oncol (Dordr)September 24, 2025Ruolan Qian, Yuchen Guo, Xiaolin Hu, Jing Ling, Haigang Geng, Qiaoqiao Ye, Linmeng Zhang, Shujie Zhan, Long Liao, Yang Ge, et al.Dacomitinib (S2727) were obtained from Selleck Chemicals. Primary antibodies targeting PTEN (9188), MET (8198), phospho-MET (3077), neurofibromin 1 (14623), phospho-AKT (4060), AKT (4685), ERBB2 (2165), ERBB3 (12708),

(14) Inhibitory Effect of Fucoidan Analogs on Highly Metastatic Gastric Cancer Cells via Galectin-4 InhibitionInternational Journal of Molecular SciencesSeptember 21, 2025Shuting Ji, Maniyamma Aswathy, Yuya Kuboki, Yoshio Takada, Kazunobu Toshima, Daisuke Takahashi, Hiroko Ideo(#62-6520) antibodies were obtained from Thermo Fisher Scientific (Waltham, MA, USA). Anti-c-MET (#8198), and anti-phospho-c-MET (Tyr1234/1235, #3077) antibodies were purchased from Cell Signaling Technology

(15) 3-O-acetylrubiarbonol B preferentially targets EGFR and MET over rubiarbonol B to inhibit NSCLC cell growthPLOS OneSeptember 8, 2025A-Young Nam, Sang Hoon Joo, Na Yeong Lee, Goo Yoon, Jin Woo Park, MinKyun Na, Jung-Hyun Shimp-MET (Rabbit, 1:1000, 3077S, AB_2143884), AKT (Rabbit, 1:1000, 4691S, AB_915783), MET (Rabbit, 1:1000, 8198S, AB_10858224), and Bax (Rabbit, 1:1000, 5023S, AB_10557411) were procured from Cell Signaling Technology

(16) Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancersCell Reports MedicineAugust 19, 2025Madelaine S. Theardy, Mitsunobu Takeda, Alexey Sorokin, Shuaitong Chen, Zecheng Yang, Xiaofei Wang, Preeti Kanikarla, Oluwadara Coker, Phuoc Nguyen, Yongkun Wei, et al.,Cell Signaling Technology,Cat#4407; RRID:AB_331795 Rabbit monoclonal anti-MET (Clone D1C2),Cell Signaling Technology,Cat#8198; RRID:AB_10858224 Rabbit monoclonal anti-phospho-MET (Clone 13D11),Cell Signaling Technology,Cat#3135;

(17) The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activityCell Commun SignalJune 19, 2025Ali N. A. Hmedat, Jessica Doondeea, Daniel Ebner, Stephan M. Feller, Marc Lewitzkyisotype control (Cell Signaling Technology, #5415) or 5 µg of MET antibody (Cell Signaling Technology, #8198) were added into the tubes containing pre-cleared lysates. Samples were agitated for 2 h at 4 °C, 10

(18) Responsiveness of different MET tumour alterations to type I and type II MET inhibitorsClin Transl MedMay 29, 2025Yonina R. Murciano-Goroff, Valentina Foglizzo, Jason Chang, Natasha Rekhtman, Ann Elizabeth Sisk, Jamie Gibson, Lia Judka, Kristen Clemens, Paola Roa, Shaza Sayed Ahmed, et al.quantified and used for Western blots. The following antibodies were used: Met (D1C2) XP® Rabbit mAb (CST, #8198S), Phospho‐Met (Tyr1234/1235) (D26) XP® Rabbit mAb (CST, #3077S), ERK (CST, #4695S), pERK T202/Y204 (CST,

(19) ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosisCell Death & DifferentiationMay 14, 2025Xu Zhang, Zihuan Wang, Yilin He, Kejin Wang, Cheng Xiang, Yongfeng Liu, Yijiang Song, Aimin Li, Zhen Wang, Yingnan Yu, et al.1:1000 dilution), NRF2 (Cell Signaling Technology, #12721S, 1:1000 dilution), c-MET (Cell Signaling, #8198S, 1:1000 dilution), GAPDH (FdBio, FD0063, 1:1000 dilution), GPX4 (Proteintech, 67763-1-Ig, 1:1000 dilution),

(20) Response of GEM models of neuroblastoma to cabozantinib assessed by multiparametric magnetic resonance imagingNeoplasiaMay 12, 2025Gilberto S. Almeida, Philippa King, Albert Hallsworth, Hannah Webber, Sergey Popov, Susana Miranda, Orli Yogev, Andrew D.J. Pearson, Louis Chesler, Yann Jamin, et al.was then incubated overnight at 4 °C with primary antibodies (1:1000, Cell Signaling) against MET (#8198), pMET (#3077), VEGFR2 (#9698) and pVEGFR2 (#2478). Following washing, the membrane was incubated with

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Met (D1C2) XP ® Rabbit mAb

Met (D1C2) XP ® Rabbit mAb from Cell Signaling Technology

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Met (D1C2) XP ® Rabbit mAb from Cell Signaling Technology

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