The RUNX1 Polyclonal Antibody, PerCP Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to RUNX family transcription factor 1, and RUNX1. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The RUNX1 Polyclonal Antibody, PerCP Conjugated has been shown to work in the following applications: Flow Cytometry, and Western Blot.
Description
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation