Apaf-1 (D5C3) Rabbit mAb 8969S from Cell Signaling Technology

Product Specs
ItemApaf-1 (D5C3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8969S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M
TargetAPAF
IsotypeIgG
HostRabbit
NCBI Gene AliasesAPAF-1, CED4
NCBI Full Gene Nameapoptotic peptidase activating factor 1
CloneD5C3
Molecular Weight135
ClonalityMonoclonal
Research AreaApoptosis

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Cytosolic cytochrome c represses ferroptosisCell metabolismJune 3, 2025Song X, Zhou Z, Liu J, Li J, Yu C, Zeh HJ, Klionsky DJ, Stockwell BR, Wang J, Kang R, et al.,Santa Cruz Biotechnology,sc-166348; RRID:AB_2091729 INPP4A,Thermo Fisher,PA5-96762; RRID:AB_2808564 APAF1,Cell Signaling Technology,8969; RRID:AB_10859039 CYCS,Abcam,ab110325; RRID:AB_10864775 CYCS,Cell Signaling Technology,12963; RRID:AB_2637072 Cleaved

(2) Hyperactivation of SREBP induces pannexin-1-dependent lytic cell deathJournal of Lipid ResearchJuly 1, 2024Yanni Xiong, Jie Luo, Zi-Yun Hong, Wen-Zhuo Zhu, Ao Hu, Bao-Liang Songmonoclonal anti-TOM20 (Proteintech, 66777-1-Ig), rabbit monoclonal anti-apaf1 (Cell signaling technology, 8969T), rabbit polyclonal anti-RIP3 (Proteintech,17563-1-AP). Plasmids The plasmid pLenti-tet-on was a generous

(3) MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinomaCell death & diseaseJune 27, 2024Olarewaju O, Hu Y, Tsay HC, Yuan Q, Eimterbäumer S, Xie Y, Qin R, Ott M, Sharma AD, Balakrishnan A.western blots are vinculin (Sigma Aldrich, #V9131), Cytochrome c (CST, #11940; ABCAM, #ab133504), APAF1 (CST, #8969), Caspase 9 (CST, #9508), and BCL-xl (CST, #2764 P). The secondary antibodies, goat anti-rabbit (ABCAM,

(4) Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D3 through upregulation of PGC-1α expression and inhibition of the mitochondrial cytochrome c pathwayHormones (Athens)February 29, 2024Liting Tang, Ke Du, Kaiming Luo, Long Wang, Fei Hua(CST, 9662 S, 1:1,000), caspase-9 (CST, 9504 S, 1:1,000), Cyt c (CST, 11,940 S, 1:1,000), Apaf-1 (CST, 8969 S, 1:1,000), β-actin (CST, 4970 S, 1:1,000), and PGC-1α (peroxisome proliferator-activated receptor-coactivator-1α)

(5) Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagyNature CommunicationsJanuary 30, 2024Shuo-Shuo Liu, Tian-Xia Jiang, Fan Bu, Ji-Lan Zhao, Guang-Fei Wang, Guo-Heng Yang, Jie-Yan Kong, Yun-Fan Qie, Pei Wen, Li-Bin Fan, et al.Santa Cruz Biotechnology, #sc-40), GFP (1:3000, Absin, #137960), Apaf-1 (1:1000, Cell Signaling Technology, #8969), PA28γ (1:3000, Enzo, #PW8190), GAPDH (1:3000, Santa Cruz Biotechnology, #25778), p62 (1:1000, Cell Signaling Technology

(6) Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunityJ Immunother CancerDecember 6, 2023Jingyang Li, Xiaoyu Han, Mayu Sun, Weida Li, Guanghuan Yang, Huiyi Chen, Bao Guo, Jingquan Li, Xiaoguang Li, Hui WangCST); anti-Caspase-3 antibody (9662; CST); anti-Caspase-9 antibody (9504; CST); anti-Apaf-1 antibody (8969; CST); anti-Phospho-TBK1 antibody (5483; CST); anti-survivin antibody (2808; CST); anti-AIF antibody

(7) CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signalingCancer Cell InternationalNovember 21, 2023Long-Long Cao, Yu-Kai Wu, Tong-Xin Lin, Mi Lin, Yu-Jing Chen, Ling-Qian Wang, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, et al.Rabbit anti-E2F-1 (1:1000; 3742 S), rabbit anti-apoptotic protease activating factor 1 (APAF1; 1:1000; 8969 S), and rabbit anti-p73 (1:1000; 14,620 S) antibodies were purchased from Cell Signaling Technology

(8) Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscleNature communicationsJuly 13, 2023Morse PT, Pérez-Mejías G, Wan J, Turner AA, Márquez I, Kalpage HA, Vaishnav A, Zurek MP, Huettemann PP, Kim K, et al.2 mg total protein from the above solutions were incubated with 4 µg rabbit anti-Apaf-1 antibody (#8969, Lot #2, Cell Signaling Technology) overnight at 4 °C. The next day, the mixtures were then incubated

(9) E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastomaCell death & diseaseSeptember 12, 2022Chen M, Zhao Z, Wu L, Huang J, Yu P, Qian J, Ni T, Zhao C.1:1000), APEX1 (Proteintech, cat.No: 10203-1-AP, 1:1000), APAF1 (Cell Signaling Technology, cat.No: #8969, 1:1000), PCNA (Arigo, cat.No: ARG62605, 1:5000), GAPDH ((Proteintech, cat.No: HRP-60004, 1:5000), β-Actin

(10) Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damageJournal of Reproduction and DevelopmentAugust 1, 2022Xiuying CHEN, Zhijing TANG, Haiyun GUAN, Hexia XIA, Chao GU, Yan XU, Bin LI, Wei ZHANG(T389) (9234), rpS6 (2217), p-rpS6 (S240/244) (5364), eIF4B (3592), p-eIF4B (S422) (3591), APAF-1 (8969), cleaved caspase 3 (9664), caspase 3 (9662), and β-tubulin (2128) were purchased from Cell Signaling Technology

(11) Promotive role of microRNA‑150 in hippocampal neurons apoptosis in vascular dementia model ratsMolecular Medicine ReportsFebruary 5, 2021Chengqun Wei, Xiuzhi Xu, Hongyan Zhu, Xiuyan Zhang, Zhan GaoHOXA1 (cat. no. ab230513; 1:5,000; Abcam), apoptotic peptidase activating factor 1 (Apaf1; cat. no. 8969; 1:2,000; Cell Signaling Technology, Inc.), p53 (cat. no. 2524; 1:5,000; Cell Signaling Technology,

(12) The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathwayCell death & diseaseDecember 8, 2020Villa E, Paul R, Meynet O, Volturo S, Pinna G, Ricci JE.(PAB6156) was purchased from Abnova. Anti-UBR2 (18853-1-AP) was purchased from Euromedex. Anti Apaf-1 (#8969), anti-Mcl1 (#94296) anti-cytochrome c (D18C7), anti-Smac (D5S3R), and Phospho-Erk1/2 Pathway Sampler Kit

(13) Propofol induces ROS-mediated intrinsic apoptosis and migration in triple-negative breast cancer cellsOncology lettersJuly 1, 2020Wang H, Zhao L, Wu J, Hong J, Wang S.Cell Signaling Technology, Inc.), cytochrome c (cat. no. 11940; 1:1,000; Cell Signaling Technology, Inc.) Apaf‑1 (cat. no. 8969; 1:1,000; Cell Signaling Technology, Inc.) and GAPDH (cat. no. 5174; 1:5,000; Cell Signaling Technology,

(14) Cepharanthine Hydrochloride Improves Cisplatin Chemotherapy and Enhances Immunity by Regulating Intestinal Microbes in MiceFrontiers in Cellular and Infection MicrobiologyJune 26, 2019Pengjun Zhou et al.(9746), Caspase-9 (9502), Caspase-3 (9662), TNFR1 (3736), CYLD (8462), JNK (9252), p-JNK (4668), Apaf-1 (8969), Bax (5023), Bcl-2 (15071), Cytochrome c (4280), NF-κB (8242), and Myd88 (4283) were purchased from

(15) Caspase-1 initiates apoptosis in the absence of gasdermin DNature communicationsMay 7, 2019Tsuchiya K, Nakajima S, Hosojima S, Thi Nguyen D, Hattori T, Manh Le T, Hori O, Mahib MR, Yamaguchi Y, Miura M, et al.(#9504, 1:1000), Bid (#2003, 1:500), RIPK3 (#15828, 1:1000), and Cytochrome c (#4272, 1:500), Apaf-1 (#8969, 1:1000) from Cell Signaling Technology; MTCO1 (ab14705, 1:1000), GSDME (ab215191, 1:1000), GSDMD (ab209845,

(16) RETRACTED ARTICLE: Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathwayJournal of Translational MedicineMarch 11, 2019Wen Su, Shuai Sun, Feng Wang, Yuehong Shen, Hongyu Yang#2947), cleaved caspase-3 (1:1000; #9661), Bax (1:1000; #14796), Bcl-2 (1:1000; #2872), Apaf-1 (1:1000; #8969), and caspase-3 (1:1000; #9662; all from Cell Signaling Technology, Danvers, MA, USA). The secondary

(17) Luteolin induces myelodysplastic syndrome‑derived cell apoptosis via the p53‑dependent mitochondrial signaling pathway mediated by reactive oxygen speciesInternational Journal of Molecular MedicineMay 18, 2018Weimin Dong, Yan Lin, Yang Cao, Yue Liu, Xiaobao Xie, Weiying Gu(Bax; cat. no. 5023T), Bcl‑2 (cat. no. 2872T), apoptotic protease activating factor 1 (Apaf1; cat. no. 8969T), cytochrome c (cat. no. 11940T), and β ‑actin (cat. no. 4967S) antibodies were obtained from Cell Signaling Technology

(18) Voltage-gated potassium channel blocker 4-aminopyridine induces glioma cell apoptosis by reducing expression of microRNA-10b-5pMolecular Biology of the CellMay 1, 2018Qin Ru, Wei-ling Li, Qi Xiong, Lin Chen, Xiang Tian, Chao-Ying Li(Wuhan, China). Antibodies against glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (5174S), Apaf-1 (8969S), cleaved caspase-3 (9664S), cleaved caspase-9 (7237S), and cleaved PARP (5625S) were purchased from

(19) Voltage-gated potassium channel blocker 4-aminopyridine induces glioma cell apoptosis by reducing expression of microRNA-10b-5pMol. Biol. CellMay 1, 2018Qin Ru, Wei-ling Li, Qi Xiong, Lin Chen, Xiang Tian, Chao-Ying Li(Wuhan, China). Antibodies against glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (5174S), Apaf-1 (8969S), cleaved caspase-3 (9664S), cleaved caspase-9 (7237S), and cleaved PARP (5625S) were purchased from

(20) Chrysotoxene induces apoptosis of human hepatoblastoma HepG2 cells inï¿½vitro and inï¿½vivo via activation of the mitochondria-mediated apoptotic signaling pathwayOncology LettersJanuary 25, 2018Chunqing Dou, Mingming Han, Bao Zhang, Liyuan Sun, Xin Jin, Tao LiCat no. 15108; rabbit anti‑human; 1:1,000), apoptotic protease activating factor‑1 (Apaf‑1; Cat no. 8969; rabbit anti‑human; 1:1,000), cleaved (c)‑caspase‑9 (Cat no. 9501; rabbit anti‑human; 1:1,000) and β

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Apaf-1 (D5C3) Rabbit mAb

Apaf-1 (D5C3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (28)

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Apaf-1 (D5C3) Rabbit mAb from Cell Signaling Technology

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