Fig 1: Effects of chronic CoQ10 therapy by i.p. injection on cardiac oxidative stress. CoQ10 was given by i.p. injection at 30 mg/kg/d for 8 weeks. A, Dysregulated expression of oxidative stress–related genes in DCM (Mst1-TG) hearts relative to that of nTG littermate controls in 3-week (n = 4 per group) and adult mice (n = 6–7 per group). B, Protein expression of NADPH oxidases 2 and 4 (NOX2 and NOX4) in nTG and DCM hearts with or without CoQ10 treatment. Data were from n = 6–7 per group. C, Myocardial oxidative stress determined by histofluorescent staining using dihydroethidium (DHE, red color) with histological quantification or by the assay of malondialdehyde (MDA). Data were from n = 6–7 LV samples per group. *P < 0.05, †P < 0.01, and #P < 0.001, ns: not significant.