The Transferrin receptor Polyclonal Antibody, RBITC Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to TFRC, and transferrin receptor. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The Transferrin receptor Polyclonal Antibody, RBITC Conjugated has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site