Fig 1: (a) Immunoreactivity to IL-31RA in skin lesions. In the TNCB 2-weeks-treated group, the nerve fiber (arrow) of the dermis was mildly immunoreactive to IL-31RA. In the TNCB 8-weeks-treated group, immunoreactivity to IL-31RA was also observed in the nerve fiber (arrow). (b) Immunoreactivity to TRPV1 in the skin lesions. In the TNCB 8-weeks-treated group, nerve fibers (arrowhead) and sebocytes (arrow) in the dermis were immunoreactive to TRPV1. In the control group, immunoreactivity to TRPV1 was only observed in the sebocytes. In the TNCB 2-weeks-treated group, there was little immunoreactivity to TRPV1. Scale bar = 100 μm.