Fig 1: Local administration of uridine supressed synovial expression of ICAM-1 and CD18.Single dose of 0, 25, 50 and 100 mg/kg of uridine was co-administered locally along with 30 µg mBSA (intra-articularly) in right knee joint in pre-sensitized mice on day 21. At day 28, mice were sacrificed and knee joints were isolated and prepared for immunohistochemistry staining and evaluation. (A) Representative Immunohistochemistry images of non-treated and treated groups for ICAM-1 and CD18 expression. (B) Immunohistochemistry scoring of non-treated and treated groups for ICAM-1 and CD18 expression (median with interquartile range). 0 mg/kg (n = 6), 25 mg/kg (n = 6), 100 mg/kg (n = 12) of uridine. * p<0.05, ** p<0.01, *** p<0.001 (Mann–Whitney).