Fig 1: PLK1 regulates FOXM1 and targets cell cycle-associated genes to participate in cell cycle. (A) Volcano plot of enriched pathways. (B) The correlation between PLK1 expression and cell cycle in KIRC. (C) Cell cycle analysis indicated the percentages of cells in the G2/M phase were increased after transfected with si-PLK1. (D) Volcano plot of correlated genes with PLK1 in KIRC. (E) Gene expression correlation between PLK1 and FOXM1 in KIRC. (F) The protein level of FOXM1, cyclin B1 and Aurora B in KIRC cells when PLK1 was down-regulated. (G) Cell cycle analysis indicated the percentages of cells in the G2/M phase were increased after transfected with si-FOXM1. (H) The protein level of FOXM1, cyclin B1 and Aurora B in KIRC cells when FOXM1 was down-regulated. (ns > 0.05, **P < 0.01, and ***P < 0.001).