Bioss Inc.'s ERCC6L Polyclonal Antibody, RBITC Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen. The ERCC6L Polyclonal Antibody, RBITC Conjugated was generated using ERCC6L as the antigen and it reacts with Homo Sapiens, and Human.
Description
ERCC6L belongs to the SNF2 ATPase family and acts as an essential component of the spindle assembly checkpoint. It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. It acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L may also play a role in the teratogenic action of alcohol