The ABCG2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ABCG2. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The ABCG2 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which mayuggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene