The AIRE Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to AIRE, and Autoimmune Regulator. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The AIRE Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED)