The Cyclin E1 Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to CCNE1, and Cyclin E1. This antibody recognizes Homo Sapiens, and Human antigen. The Cyclin E1 Rabbit mAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Cyclin E1 and cyclin E2 can associate with and activate CDK2. Upon DNA damage, upregulation/activation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. Cyclin E1 is phosphorylated at multiple sites in vivo including Thr62, Ser88, Ser72, Thr380 and Ser384, and is controlled by at least two kinases, CDK2 and GSK-3