The Rabbit Anti-SPHK1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to sphingosine kinase 1, and SPHK1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Rabbit Anti-SPHK1 Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]