The Rabbit Anti-Presenilin 1 Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to Presenilin 1, and PSEN1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Rabbit Anti-Presenilin 1 Antibody has been shown to work in the following applications: Western Blot.
Description
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined