The DGCR8 Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to DGCR8. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The DGCR8 Rabbit mAb Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs