The PHD1 Rabbit mAb Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to EGLN2. This antibody recognizes Homo Sapiens, Human, and Rat antigen. The PHD1 Rabbit mAb Antibody has been shown to work in the following applications: Western Blot.
Description
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex