The Integrin beta 3 Mouse mAb Antibody from MyBioSource.com is a Mouse Monoclonal antibody to ITGB3. This antibody recognizes Homo Sapiens, and Human antigen. The Integrin beta 3 Mouse mAb Antibody has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity)