The Anti-RNF8 Antibody Picoband from MyBioSource.com is a Rabbit Polyclonal antibody to RNF8. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The Anti-RNF8 Antibody Picoband has been shown to work in the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, and Western Blot.
Description
E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants