The Anti-SERBP1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen. The Anti-SERBP1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
SERPINE1 mRNA-binding protein 1 (SERBP1) is an arginine-methylated RNA-binding protein whose modification affects protein interaction and intracellular localization. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynecological cancers as well since upregulation of SERBP1 was described in ovarian cancer. SERBP1 is an RNA-binding protein containing an RG-rich domain and an RGG box domain that might be methylated by protein arginine N-methyltransferases (PRMTs). SERBP1 is the first example of an RNA-binding protein functioning as a central regulator of cancer metabolism and an indirect modulator of epigenetic regulation in glioblastoma (GBM). By bridging these two processes, SERBP1 enhances glioma stem cell phenotypes and contributes to GBM's poorly differentiated state