MyBioSource.com's Lamin B Receptor Rabbit mAb is a Rabbit monoclonal antibody. The Lamin B Receptor Rabbit mAb Antibody was generated using Lamin B Receptor, and LBR as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified