The Histone H3 Phospho (RBT-pHH3), Rmab Antibody from MyBioSource.com is a Rabbit Monoclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen.
Description
Phosphohistone-H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the “beads on a string” structure. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis.
Phosphohistone-H3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in identification of tumor grades, especially in CNS, skin, gynecologic tissues, soft tissue, and gastrointestinal stromal tumors (GIST)