The SCAF8 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SCAF8. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The SCAF8 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit (POLR2A, and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation